Organic Medicinal and Pharmaceutical
Chemistry (PCHEM 2) Final Exam
Questions and Correct Answers
2025\2026 Version.
Ethambutol - Answer It is a comparatively weak antitubercular drug; its principal use is as the
secondary drug to avoid resistance problems:
a. Rifampicin
b. Isoniazid
c. Ethambutol
d. Pyrazinamide
Amino group - Answer Responsible for the broad spectrum activity of amoxicillin and
ampicillin
a. Benzyl group
b. Amino group
c. Hydroxyl group
d. Methyl group
Isoniazid - Answer It is the most powerful and active antitubercular drug
a. Rifampicin
b. Isoniazid
c. Ethambutol
d. Pyrazinamide
Dimethylamino - Answer Macrolides are basic due to
a. Dimethylamino
,Isoxazolylpenicillin - Answer MRSA is a developed antimicrobial resistance known worldwide.
MRSA is an issue to what group of penicillin?
a. Aminopenicillin
b. Isoxazolylpenicillin
c. Carboxypenicillin
d. Ureidopenicillin
Dephosphorylation of the phospholipid that carries the peptidoglycan subunit - Answer
Bacitracin is a cyclic polypeptide antibiotic that prevents
a. Phosphorylation of the phospholipid that carries the peptidoglycan subunit
b. Dephosphorylation of the phospholipid that carries the peptidoglycan subunit
c. Decarboxylation of the phospholipid that carries the peptidoglycan subunit
d. Carboxylation of the phospholipid that carries the peptidoglycan subunit
Imipenem is susceptible to beta lactamases and inactivated dehydropeptidases in renal tubules
- Answer Which of the following statements is not a property of carbepenems?
a. Meropenem is similar to imepenem in pharmacology and antimicrobial spectrum of activity
b. Imipenem is susceptible to beta lactamases and inactivated dehydropeptidases in renal
tubules
c. Doripenem is the most recent carbepenem to be approved for use
d. Ertapenem has a long half-life suitable for once-daily administration
Class II - Answer Has a potent antibacterial activity with transient inhibition of beta-lactamase
a. Class I
b. Class II
c. Class III
d. Class IV
,c. Nalidixic acid
d. Nitrofurantoin
Methenamine
Octahydronanaphthacene - Answer Four annulated six- membered rings
a. Lactone
b. Octahydronanaphthacene
c. Dihydrothiazine
d. Thiazoladine
HPV - Answer Tumor viruses
a. HPV
b. HIV
c. HSV
d. HAV
All of the choices (A,B,C) - Answer Viral taxonomy based on genome
a. DNA/RNA
b. Linear/circular
c. Ss/ds
d. All of the choices
Nevirapine - Answer NNRTI of dipyridodiazepine derivative
a. Nevirapine
b. Delavirdine
c. Efavirenz
d. Atripla
, b. Saquinavir
c. Ritonavir
d. Lopinavir
C6 - Answer Tetracycline SAR: The most fruitful site of modification
a. C1
b. C2
c. C5
d. C6
30S - Answer Tetracyclines bind to what ribosomal subunit
a. 30S
b. 50S
c. 40S
d. 60S
Doxycline - Answer Tetracycline prophylaxis for leptospirosis and malaria
a. Minocycline
b. Doxycline
c. Demeclocycline
d. Chlortetracycline
I and III - Answer Contribute to unequaled importance of B-lactam antibiotic
I. Potency
II. Rapid bacteriostatic
III. Low toxicity in the host
a. I and II
Chemistry (PCHEM 2) Final Exam
Questions and Correct Answers
2025\2026 Version.
Ethambutol - Answer It is a comparatively weak antitubercular drug; its principal use is as the
secondary drug to avoid resistance problems:
a. Rifampicin
b. Isoniazid
c. Ethambutol
d. Pyrazinamide
Amino group - Answer Responsible for the broad spectrum activity of amoxicillin and
ampicillin
a. Benzyl group
b. Amino group
c. Hydroxyl group
d. Methyl group
Isoniazid - Answer It is the most powerful and active antitubercular drug
a. Rifampicin
b. Isoniazid
c. Ethambutol
d. Pyrazinamide
Dimethylamino - Answer Macrolides are basic due to
a. Dimethylamino
,Isoxazolylpenicillin - Answer MRSA is a developed antimicrobial resistance known worldwide.
MRSA is an issue to what group of penicillin?
a. Aminopenicillin
b. Isoxazolylpenicillin
c. Carboxypenicillin
d. Ureidopenicillin
Dephosphorylation of the phospholipid that carries the peptidoglycan subunit - Answer
Bacitracin is a cyclic polypeptide antibiotic that prevents
a. Phosphorylation of the phospholipid that carries the peptidoglycan subunit
b. Dephosphorylation of the phospholipid that carries the peptidoglycan subunit
c. Decarboxylation of the phospholipid that carries the peptidoglycan subunit
d. Carboxylation of the phospholipid that carries the peptidoglycan subunit
Imipenem is susceptible to beta lactamases and inactivated dehydropeptidases in renal tubules
- Answer Which of the following statements is not a property of carbepenems?
a. Meropenem is similar to imepenem in pharmacology and antimicrobial spectrum of activity
b. Imipenem is susceptible to beta lactamases and inactivated dehydropeptidases in renal
tubules
c. Doripenem is the most recent carbepenem to be approved for use
d. Ertapenem has a long half-life suitable for once-daily administration
Class II - Answer Has a potent antibacterial activity with transient inhibition of beta-lactamase
a. Class I
b. Class II
c. Class III
d. Class IV
,c. Nalidixic acid
d. Nitrofurantoin
Methenamine
Octahydronanaphthacene - Answer Four annulated six- membered rings
a. Lactone
b. Octahydronanaphthacene
c. Dihydrothiazine
d. Thiazoladine
HPV - Answer Tumor viruses
a. HPV
b. HIV
c. HSV
d. HAV
All of the choices (A,B,C) - Answer Viral taxonomy based on genome
a. DNA/RNA
b. Linear/circular
c. Ss/ds
d. All of the choices
Nevirapine - Answer NNRTI of dipyridodiazepine derivative
a. Nevirapine
b. Delavirdine
c. Efavirenz
d. Atripla
, b. Saquinavir
c. Ritonavir
d. Lopinavir
C6 - Answer Tetracycline SAR: The most fruitful site of modification
a. C1
b. C2
c. C5
d. C6
30S - Answer Tetracyclines bind to what ribosomal subunit
a. 30S
b. 50S
c. 40S
d. 60S
Doxycline - Answer Tetracycline prophylaxis for leptospirosis and malaria
a. Minocycline
b. Doxycline
c. Demeclocycline
d. Chlortetracycline
I and III - Answer Contribute to unequaled importance of B-lactam antibiotic
I. Potency
II. Rapid bacteriostatic
III. Low toxicity in the host
a. I and II
