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How will renal insufficiency affect drug elimination? - ANSWER-
The kidney is the primary organ of excretion for most drugs.
General theme of metabolism is to produce drug metabolites
that are more water soluble and more easily removed by the
kidneys. The rate at which the drug is excreted by the kidneys
depends on several factors. Renal blood flow influences the
glomerular filtration rate (GFR) which is how much plasma is
filtered per minute by the glomerulus.
Renal excretion of drugs is typically well-characterized, what is
variable is the -
ANSWER-level of renal function the
patient.
It is common to monitor renal function in patients by the
clinical setting and to
adjust dosages based on renal function. This is typically
assessed by the -
,ANSWER-serum
creatinine.
Patients with poor renal function may have higher levels of
drugs secondary to -
ANSWER-decreased excretion of
metabolites.
What is off-label prescribing? - ANSWER-Off-label use is the
use of pharmaceutical drugs for an unapproved indication or an
unapproved age group, dosage or route of administration.
What factors place an infant and child at risk when prescribing
medication? - ANSWER-In general, there is a lack of safety and
efficacy studies in the pediatric population most medications
are studied in adult populations which because of age-related
differences and medication metabolism and mechanisms of
action don't necessarily apply to pediatric populations.
Children are not just small adults. Adverse drug reactions are
most common in this age group. Kids do not have a fully
mature liver and renal function, and are at higher risk for
toxicity and adverse drug effects.
,In kids, meds should be - ANSWER-weight based. Kids do not
have a fully mature liver and renal function, and are at higher
risk for toxicity and adverse drug effects.
What ADRs are the elderly at risk of developing? - ANSWER-
Physiologic changes in older adults increase the risk of harm
for medication metabolized by the liver and kidneys.
In the elderly, Hepatic blood flow decreases by - ANSWER-
nearly one-half or
40% in older
adults.
some degree of chronic kidney disease is present in X
of older adult -
ANSWER-
50%
Furthermore, the median renal blood flow decreases by X by
the time the patient reaches 80 years of age, and x - ANSWER-x
of older adults maintain normal kidney function/50%, 1/3.
Although, the normal individual rate of decline varies and one-
third of older adults maintain normal renal function.
, All cholinergic blockers are used to treat - ANSWER-spastic or
hyperactive conditions of the GI and urinary tracts because
they relax muscles and decrease GI secretions. These drugs
may be used to relax the bladder and to treat urinary
incontinence. The quaternary ammonium and amine
compounds such as propantheline are the drugs of choice for
these conditions because they cause fewer adverse reactions
than belladonna alkaloids. •
What are Belladonna alkaloids? - ANSWER-This is used with
morphine to treat
biliary colic (pain caused by stones in the
bile duct). •
Cholinergic blocking drugs are given by injection before such
diagnostic procedures as endoscopy and sigmoidoscopy to -
ANSWER-relax the GI smooth muscle.
Who gives the ARNP authority to practice and prescribe
medications? -
ANSWER-It's the state board of nursing in your
respective state
Carvedilol is what type of blocker and what is its brand
name? - ANSWER-