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Already Graded A+
MHC Class I - 🧠 ANSWER ✔✔display antigens from intracellular pathogens
interact with CD8
expressed on ALL cells
MCH Class II - 🧠 ANSWER ✔✔display antigens from extracellular pathogens.
interact with CD4
expressed on APCs
humoral immunity - 🧠 ANSWER ✔✔antibody-mediated immunity
involves B cells
, cell-mediated immunity - 🧠 ANSWER ✔✔type of immunity produced by T cells
that attack infected or abnormal body cells
isotype of antibody - 🧠 ANSWER ✔✔determined by constant region of heavy
chain
somatic recombination - 🧠 ANSWER ✔✔gene segments of antibody rearrange to
form variable domain gene
junctional diversity - 🧠 ANSWER ✔✔source of antibody diversity
RAG yields DNA hairpin which is then cleaved, TdT adds nucleotides at random,
gaps filled by DNA synthesis
isotope class switching - 🧠 ANSWER ✔✔VDJ region is brought to a new constant
region of the heavy chain
heavy chain constant region determined by cytokines
constant region=isotype
isotype class switching signals - 🧠 ANSWER ✔✔1. CD40 ligand (on T cell)
interacts with CD40 on B cell
2. Cytokine determines isotype class