Weak Bonds
properties not redundant
in common is
onlything
that they are weak
, 2 molecules so close that they
van der Waals touch
doesn't usually
interactions of dipoles
rive chemical rxn no interactions if molecules aren
δ+ δ-
1C so weak usually touching or temp dependent
δ- δ+ no pH
oretty equal onMN within normal ranges active sites
0th sides of important in enzyme
net charges0 membranes in hydrophobic interior
weakest b w any 2 molecules
ionic bonds (+/-) (salt bridges) magnitude of charges
value
0W solvent cabs
bond F of.ge Coulomb's Law
affects
E r2
distance
dielectric constant shielding
St pH dependent bic presence
r 1 affects charge
+ S H ─ absence of ε H
O vacuum
f Hft good 1
dissginose benzene
electric
dipole
a 2.3 I refypsonfeattffe
water has water
80
as r increases dipole L diminishing force of attracr
the bond weakens good at fold i steals
80 e density
, g
hydrogen bonds need 3atoms i 3 dots indicates A bond EI
serine R1 Goy ionic electrostatic o N s
tyrosine δ- δ+ δ-
covalent covalent bond btw EN
threonine R – O-H O C δ+ 104 atom H
overlap of orbitals
R
0
Hr donor acceptor 2 depends on
its hats ketone wider angle weaker Linear stronger
can make 4bonds on it
Max occurs in ICE R OH weaker btc angle
quid has fewer
hydrophobic effect I
population effect
CH3CH2CH2CH2CH3
4 Hbonds pentane
4 can't form clathrate forming Max of Hbo
H bonds blC around pentane icelayers
g
stsniopsey
Hbond not EN
forming when two
bonds eclatherates
Tdifferent t
moearteoffeitehaes
20s all Of
hetime i t
H2O form ice like notal
stable situation to but ma
structures around
differing pentane Be
thomas
water molecules structure 08
2
forming H bondshydrophobiceffect need hydrophobeBE4
1 eachother 3
is
, g n
room temp less dense than water
f
spontaneous
RT
thanHzO
heat notchanging
in correctdirection
notdriving1 xn more
I I c 7 dense
most hydrophobes ΔG = ΔH M
- TΔS waters exclude hydrophob
Still have clathrates
have
density water heat entropy where hydrophobes H2O
t interact
hatwould happen if thetempwent C
rom 250C to hear freezing Explain
It doesn'tmattertemperature
does a c forms Ihroomesnybarkopnboebies
disappear ordered
ayer of hydrophobes perspective SG Ct
make water more ice like
you Theyblendin b c becoming
y lowering temp b t for water
more disordered drivingrx
IG SH TAS spontaneous
to be AG
Depends HIGHLYon temp
like a water driven effect
,Hydrophobic effect is the driving force in forming
the three dimensional shapes of:
1 proteins structure mostly directed
by hydrophobic effect
2 DNA drives double helix structure
intertwinning ssDNA
3 Membrane helps form
, dou e
morepolarwater stranded
in
ss DNA b c more ss DNA ds DNA
f charge
a Bao
B 3 H bon
G FB C G C
is 00 on phosphates
Br T A 2 H Bon
Es
Es
21
Mg
Tcontrast
and stabit
cations
use
ion proteins main force
f
driving
hatred q
are H2O
Destabilizers stabilizer
1 7 from 40 H bonds b w
repulsion phosphates G C A 7
NO Effects 60 from
An arrow
on each side of
same
Vandet Waals
hydrophobic
properties not redundant
in common is
onlything
that they are weak
, 2 molecules so close that they
van der Waals touch
doesn't usually
interactions of dipoles
rive chemical rxn no interactions if molecules aren
δ+ δ-
1C so weak usually touching or temp dependent
δ- δ+ no pH
oretty equal onMN within normal ranges active sites
0th sides of important in enzyme
net charges0 membranes in hydrophobic interior
weakest b w any 2 molecules
ionic bonds (+/-) (salt bridges) magnitude of charges
value
0W solvent cabs
bond F of.ge Coulomb's Law
affects
E r2
distance
dielectric constant shielding
St pH dependent bic presence
r 1 affects charge
+ S H ─ absence of ε H
O vacuum
f Hft good 1
dissginose benzene
electric
dipole
a 2.3 I refypsonfeattffe
water has water
80
as r increases dipole L diminishing force of attracr
the bond weakens good at fold i steals
80 e density
, g
hydrogen bonds need 3atoms i 3 dots indicates A bond EI
serine R1 Goy ionic electrostatic o N s
tyrosine δ- δ+ δ-
covalent covalent bond btw EN
threonine R – O-H O C δ+ 104 atom H
overlap of orbitals
R
0
Hr donor acceptor 2 depends on
its hats ketone wider angle weaker Linear stronger
can make 4bonds on it
Max occurs in ICE R OH weaker btc angle
quid has fewer
hydrophobic effect I
population effect
CH3CH2CH2CH2CH3
4 Hbonds pentane
4 can't form clathrate forming Max of Hbo
H bonds blC around pentane icelayers
g
stsniopsey
Hbond not EN
forming when two
bonds eclatherates
Tdifferent t
moearteoffeitehaes
20s all Of
hetime i t
H2O form ice like notal
stable situation to but ma
structures around
differing pentane Be
thomas
water molecules structure 08
2
forming H bondshydrophobiceffect need hydrophobeBE4
1 eachother 3
is
, g n
room temp less dense than water
f
spontaneous
RT
thanHzO
heat notchanging
in correctdirection
notdriving1 xn more
I I c 7 dense
most hydrophobes ΔG = ΔH M
- TΔS waters exclude hydrophob
Still have clathrates
have
density water heat entropy where hydrophobes H2O
t interact
hatwould happen if thetempwent C
rom 250C to hear freezing Explain
It doesn'tmattertemperature
does a c forms Ihroomesnybarkopnboebies
disappear ordered
ayer of hydrophobes perspective SG Ct
make water more ice like
you Theyblendin b c becoming
y lowering temp b t for water
more disordered drivingrx
IG SH TAS spontaneous
to be AG
Depends HIGHLYon temp
like a water driven effect
,Hydrophobic effect is the driving force in forming
the three dimensional shapes of:
1 proteins structure mostly directed
by hydrophobic effect
2 DNA drives double helix structure
intertwinning ssDNA
3 Membrane helps form
, dou e
morepolarwater stranded
in
ss DNA b c more ss DNA ds DNA
f charge
a Bao
B 3 H bon
G FB C G C
is 00 on phosphates
Br T A 2 H Bon
Es
Es
21
Mg
Tcontrast
and stabit
cations
use
ion proteins main force
f
driving
hatred q
are H2O
Destabilizers stabilizer
1 7 from 40 H bonds b w
repulsion phosphates G C A 7
NO Effects 60 from
An arrow
on each side of
same
Vandet Waals
hydrophobic
