WITH SOLUTIONS RATED A+
✔✔How does increased elimination affect drug exposure during pregnancy? -
✔✔Increased elimination results in decreased drug exposure.
✔✔What can pregnancy cause in terms of medication levels? - ✔✔Pregnancy can
produce decreased medication levels for medications requiring therapeutic monitoring
regarding dose alterations despite adherence to the prescribed regimen.
✔✔What types of medications do pregnant women take? - ✔✔Pregnant women take
various over-the-counter (OTC) and prescription medications.
✔✔What are some physiological changes during pregnancy that affect
pharmacokinetics? - ✔✔Physiological changes during pregnancy include increases in
drug-metabolizing enzymes, altered body composition, organ blood flow, and increased
glomerular filtration rate.
✔✔What factors affect medication absorption in infants? - ✔✔Prolonged GI tract
emptying time, variable peristalsis, decreased gastric pH, and differing blood flow to
tissues.
✔✔How is medication distribution altered in newborns and infants? - ✔✔Increased total
body water, decreased body fat, and decreased levels of plasma proteins.
✔✔What affects the metabolism of medications in newborns and infants? - ✔✔Delays in
drug-metabolizing enzymes.
✔✔How is medication excretion reduced in newborns and infants? - ✔✔Lower
glomerular filtration rate, decreased renal blood flow, and liver immaturity prolonging
medication half-life.
✔✔What are prescription drugs? - ✔✔Medications that can only be prescribed by
authorized prescribers.
✔✔Who can prescribe prescription drugs? - ✔✔Licensed clinicians authorized by law.
✔✔What are the two groups of authorized prescribers? - ✔✔Physician and
nonphysician prescribers.
✔✔What did the Institute of Medicine (IOM) report recommend? - ✔✔Enhanced nursing
education and removal of practice restrictions.