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,Table of contents
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Chapter i 1 i - i Cellular i Biology __________________________________________________________ 3
Chapter i 2 i - i Altered i Cellular i and i Tissue i Biology i Environmental i Agents 16 i Chapter i 3 i -
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i The i Cellular iEnvironment iFluids iand iElectrolytes iAcids iand
Bases ______________________________________________________________________________ 28
Chapter i4 i- iGenes i and iGenetic i Diseases _________________________________________________ 41
Chapter i5 i- i Genes i Environment-Lifestyle iand i Common iDiseases _____________________________ 51
Chapter i6 i- iEpigenetics i and iDisease _____________________________________________________ 59
Chapter i7 i - i Innate iImmunity iInflammation _________________________________________________ 64
Chapter i8 i- iAdaptive iImmunity __________________________________________________________ 78
Chapter i9 i- i Alterations i in iImmunity iand iInflammation _____________________________________ 89
Chapter i10 i- iInfection _______________________________________________________________ 102
Chapter i11 i- iStress iand iDisease ______________________________________________________ 110
Chapter i12 i- iCancer iBiology__________________________________________________________ 117
Chapter i13 i - i Cancer iEpidemiology_____________________________________________________ 129
Chapter i14 i- i Cancer iin iChildren _______________________________________________________ 135
Chapter i15 i- iStructure i and iFunction i of ithe iNeurologic iSystem______________________________ 140
Chapter i 16 i - i Pain i Temperature i Regulation i Sleep i and i Sensory i Function i 151 i Chapter i 17 i -
i Alterations i in iCognitive iSystems iCerebral iHemodynamics iand
Motor iFunction _____________________________________________________________________ 165
Chapter i18 i- i Disorders iof ithe iCentral i and iPeripheral i Nervous i Systems iand
the iNeuromuscular iJunction___________________________________________________________ 179
Chapter i19 i- iNeurobiology iof iSchizophrenia iMood iDisorders iand iAnxiety iDisorders 189
Chapter i20 i- i Alterations iof i Neurologic iFunction iin iChildren ________________________________ 195
Chapter i 21 i - i Mechanisms i of i Hormonal i Regulation i i i i i i i i i i i i i
i i i i i i i i i i i i i i 202 iChapter i22 i- i Alterations i of i Hormonal
i Regulation _________________________________________________________________________ 211
Chapter i23 i- iObesity iand i Disorders i of i Nutrition iNEW _____________________________________ 223
Chapter i24 i- iStructure iand iFunction iof i the iReproductive iSystems___________________________ 228
Chapter i25 i- i Alterations i of i the iFemale iReproductive i System _______________________________ 237
,Chapter i26 i- iAlterations i of ithe iMale iReproductive iSystem _________________________________ 246
Chapter 27 - Sexually Transmitted Infections __________________________ 252
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Chapter 28 - Structure and Function of the Hematologic System ___________ 260
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Chapter 29 - Alterations of Erythrocyte Platelet and Hemostatic Function ____ 270
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Chapter 30 - Alterations of Leukocyte and Lymphoid Function _____________ 280
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Chapter 31 - Alterations of Hematologic Function in Children _____________ 287
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Chapter 32 - Structure and Function of the Cardiovascular and Lymphatic
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i Systems _______________________________________________________ 297
Chapter 33 - Alterations of Cardiovascular Function _____________________ 309
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Chapter 34 - Alterations of Cardiovascular Function in Children ____________ 323
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Chapter 35 - Structure and Function of the Pulmonary System ____________ 331
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Chapter 36 - Alterations of Pulmonary Function ________________________ 341
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Chapter 37 - Alterations of Pulmonary Function in Children _______________ 357
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Chapter 38 - Structure and Function of the Renal and Urologic Systems ____ 365
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Chapter 39 - Alterations of Renal and Urinary Function __________________ 375
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Chapter 40 - Alterations of Renal and Urinary Tract Function in Children ____ 385
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Chapter 41 - Structure and Function of the Digestive System _____________ 393
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Chapter 42 - Alterations of Digestive Function__________________________ 404
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Chapter 43 - Alterations of Digestive Function in Children ________________ 415
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Chapter 44 - Structure and Function of the Musculoskeletal System ________ 424
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Chapter 45 - Alterations of Musculoskeletal Function ____________________ 436
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Chapter 46 - Alterations of Musculoskeletal Function in Children ___________ 448
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Chapter 47 - Structure Function and Disorders of the Integument __________ 457
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Chapter 48 - Alterations of the Integument in Children ___________________ 468
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Chapter 49 - Shock Multiple Organ Dysfunction Syndrome and Burns in
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Adults _________________________________________________________ 476
Chapter 50 - Shock Multiple Organ Dysfunction Syndrome and Burns in
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, Children________________________________________________________ 483