BIOC 384 (Module 8) - Exam 3 Study Guide
Questions And Correct Answers (Verified Answers) |
Already Graded A+ | New Update 2025
_____ proteins autophosphorylate the cytoplasmic domain as an initialing step in
a phosphorylation-mediated signaling cascade - ANSWER receptor tyrosine
kinase (RTK)
- located on the cytosolic side
In many cases, the molecular basis of cancer is due to altered signaling pathways
through DNA mutations in either cancer promoting genes or cancer inhibitory
genes: true or false? - ANSWER true
Insulin signaling initiates two pathways: - ANSWER - one that signals through
Ras/MAPK signaling (leads to cell growth)
- the other one signals through PI-3K signaling (leads to glucose uptake)
_____ bind to receptor tyrosine kinases (RTKs) encoding an intrinsic tyrosine
kinase activity, which is activated by receptor dimerization and required for
autophosphorylation and phosphorylation of target proteins - ANSWER
growth factors
- phosphorylation leads to an adapter structure which triggers downstream
signaling
,Epidermal growth-factor receptor (EGFR) function: - ANSWER Receptor
tyrosine kinase (RTK) that binds the epidermal growth factor
Growth factor receptor-bound 2 (GRB2) function: - ANSWER adaptor protein
that binds epidermal growth factor receptors
Mitogen-activated protein kinase (MAP kinase) function: - ANSWER enzyme
with kinase activity
MAP/ERK kinase (MEK) function: - ANSWER enzyme with kinase activity
Rat sarcoma protein (Ras) function: - ANSWER G protein with GTPase activity
Src kinase homology 2 (SH2): - ANSWER adapter domain that binds
phosphotyrosine residues
Src kinase homology 3 function: - ANSWER adapter protein that binds proline-
rich sequences
EGF binding to each monomer induces receptor dimerization that stimulates
_____ activity in one receptor (EGFR1) - ANSWER kinase
- EGFR1 phosphorylates tyrosine residues in the paired receptor (EGFR2)
Place the following steps describing receptor tyrosine kinase (RTK) signaling in
proper order:
, A. phosphorylation of RTK cytoplasmic tails
B. activation of downstream signaling pathways
C. ligand binding, receptor dimerization, and kinase activation
D. protein binding to RTK phosphotyrosines and phosphorylation of target
proteins - ANSWER C, A, D, B
Upstream EGF receptor signaling involves adaptor proteins... - ANSWER GRB2
(adapter protein) and SOS (GEF protein)
GRB2 and SOS link the RTK to the G protein _____ - ANSWER Ras
- this stimulates the downstream signaling pathways and is related to the Gs
family of proteins
RasGAP stimulates ATPase in Ras to deactivate Ras signaling: true or false? -
ANSWER true
- GTP -> GDP
_____ is an EGF receptor SH2 adaptor protein - ANSWER Growth factor
receptor-bound 2 (GRB2)
Questions And Correct Answers (Verified Answers) |
Already Graded A+ | New Update 2025
_____ proteins autophosphorylate the cytoplasmic domain as an initialing step in
a phosphorylation-mediated signaling cascade - ANSWER receptor tyrosine
kinase (RTK)
- located on the cytosolic side
In many cases, the molecular basis of cancer is due to altered signaling pathways
through DNA mutations in either cancer promoting genes or cancer inhibitory
genes: true or false? - ANSWER true
Insulin signaling initiates two pathways: - ANSWER - one that signals through
Ras/MAPK signaling (leads to cell growth)
- the other one signals through PI-3K signaling (leads to glucose uptake)
_____ bind to receptor tyrosine kinases (RTKs) encoding an intrinsic tyrosine
kinase activity, which is activated by receptor dimerization and required for
autophosphorylation and phosphorylation of target proteins - ANSWER
growth factors
- phosphorylation leads to an adapter structure which triggers downstream
signaling
,Epidermal growth-factor receptor (EGFR) function: - ANSWER Receptor
tyrosine kinase (RTK) that binds the epidermal growth factor
Growth factor receptor-bound 2 (GRB2) function: - ANSWER adaptor protein
that binds epidermal growth factor receptors
Mitogen-activated protein kinase (MAP kinase) function: - ANSWER enzyme
with kinase activity
MAP/ERK kinase (MEK) function: - ANSWER enzyme with kinase activity
Rat sarcoma protein (Ras) function: - ANSWER G protein with GTPase activity
Src kinase homology 2 (SH2): - ANSWER adapter domain that binds
phosphotyrosine residues
Src kinase homology 3 function: - ANSWER adapter protein that binds proline-
rich sequences
EGF binding to each monomer induces receptor dimerization that stimulates
_____ activity in one receptor (EGFR1) - ANSWER kinase
- EGFR1 phosphorylates tyrosine residues in the paired receptor (EGFR2)
Place the following steps describing receptor tyrosine kinase (RTK) signaling in
proper order:
, A. phosphorylation of RTK cytoplasmic tails
B. activation of downstream signaling pathways
C. ligand binding, receptor dimerization, and kinase activation
D. protein binding to RTK phosphotyrosines and phosphorylation of target
proteins - ANSWER C, A, D, B
Upstream EGF receptor signaling involves adaptor proteins... - ANSWER GRB2
(adapter protein) and SOS (GEF protein)
GRB2 and SOS link the RTK to the G protein _____ - ANSWER Ras
- this stimulates the downstream signaling pathways and is related to the Gs
family of proteins
RasGAP stimulates ATPase in Ras to deactivate Ras signaling: true or false? -
ANSWER true
- GTP -> GDP
_____ is an EGF receptor SH2 adaptor protein - ANSWER Growth factor
receptor-bound 2 (GRB2)
