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What55is55ACHE?55-
55 ✔✔✔55Correct55Answer55>55Acetylcholine55esterase55is55an55enzyme55th
at55metabolizes55ACh.
What55are55the55active55metabolites55of55benzodiazepines?55-
55 ✔✔✔55Correct55Answer55>55Diazepam55(with55a55half-
life55exceeding5510055hours)55and55midazolam55(rapidly55metabolized55to5
an55α-hydroxylated55compound55with55biologic55activity).
5
What55effect55do55high55doses55of55benzodiazepines55have55on55CMR0255&55
CBF?55-
✔✔✔55Correct55Answer55>55They55reduce55CMR0255&55CBF.
,What55are55the55adverse55effects55of55midazolam?55-
✔✔✔55Correct55Answer55>55Prolonged55sedation,55impaired55cognitio
55
n55and55psychomotor55performance,55unwanted55amnesia,55potential55
for55delirium,55increased55risk55of55accidents55and55falls,55dependence55
and55withdrawal55effects
What55effect55do55benzodiazepines55have55on55the55threshold55to55local
55 anesthetic-induced55seizures?55-
✔✔✔55Correct55Answer55>55They55increase55the55threshold55to55local55
55
anesthetic-induced55seizures.
Which55benzodiazepines55have55no55active55metabolites?55-
✔✔✔55Correct55Answer55>55Oxazepam,55lorazepam,55and55temazepam.
55
What55factors55can55alter55the55metabolism55of55benzodiazepines?55-
55✔✔✔
Correct55Answer55>55Disease55and55age.
,What55is55the55duration55of55action55of55benzodiazepines55primarily55deter
mined55by?55-55✔✔✔55Correct55Answer55>55The55α55phase55(distribution-
redistribution55from55CNS)55dynamics55rather55than55the55rate55of55elimi
nation.
What55are55the55pharmacodynamic55effects55of55benzodiazepines55on55th
e55CNS?55-
55 ✔✔✔55Correct55Answer55>55CNS55depressant55effects55including55anxi
olysis,55sedation,55sleep,55anticonvulsant,55amnesia,55muscle55relaxatio
n,55and55inhibition55of55alcohol55withdrawal55symptoms.
What55is55the55dose-
related55effect55of55benzodiazepines55on55anterograde55amnesia?55-
✔✔✔55Correct55Answer55>55They55cause55anterograde55amnesia55at55hi
55
gh55doses.
What55are55the55potential55drawbacks55of55benzodiazepine55use?55-55✔✔✔
, Correct55Answer55>55Awareness55regarding55addiction,55withdrawal,