BMS 704: Immunology Part II
(hypersensitivity) Exam Questions and
Answers
allergy, hives Type I hypersensitivity is the reaction most commonly thought of as
___________________ with the classical symptom being ______________.
within minutes How long does it take for a type 1 hypersensitivity reaction to occur?
binding of Ag by IgE which is mounted on Fc receptors on mast cells What is the
initiating step in type I hypersensitivity reactions?
immediate phase - increased vascular permeability, vasodilation, increased/decreased smooth
muscle contraction and glandular secretion What is the first phase of type I
hypersensitivity reactions?
a few hours How long does the first phase of type I hypersensitivity reactions last?
late phase - infiltration of tissues with eosinophils, neutrophils, basophils, monocytes, and CD4+
TA cells. tissue destruction occurs (mucosal epithelial cell damage) What is the second
phase of type I hypersensitivity reactions?
2-24 hours after initial exposure WITHOUT additional exposure When does the second
phase of type I hypersensitivity reactions occur?
, mast cells
near blood vessels and nerves in subepithelial sites Which cells mediate type I
hypersensitivity reactions? Where are these cells found?
degranulation Mast cell activity is responsible for what cellular consequence?
cross-linking of IgE bound to IgE Fc receptors, complement factors C3a and C5a, physical
stimuli What are the ways in which mast cells can be triggered to initiate degranulation?
eosinophils The late phase response in type I hypersensitivity reactions is characterized by
a heavier involvement of what?
IL-5 produced by Th2 and mast cells What are eosinophils in the late phase of type I
hypersensitivity reactions recruited by?
release proteolytic enzymes, major basic protein, and eosinophilic cationic protein
produce LTC4
direct tissue damage and further mast cell degranulation
amplify and sustain response in absence of triggering antigen What do eosinophils do in
type I hypersensitivity reactions? What is the net result of these actions?
decreased infections in early childhood, as observed in 'developed' countries correlates with
increased incidence of type I hypersensitivity. reduced exposure to microbes is thought to reset
(hypersensitivity) Exam Questions and
Answers
allergy, hives Type I hypersensitivity is the reaction most commonly thought of as
___________________ with the classical symptom being ______________.
within minutes How long does it take for a type 1 hypersensitivity reaction to occur?
binding of Ag by IgE which is mounted on Fc receptors on mast cells What is the
initiating step in type I hypersensitivity reactions?
immediate phase - increased vascular permeability, vasodilation, increased/decreased smooth
muscle contraction and glandular secretion What is the first phase of type I
hypersensitivity reactions?
a few hours How long does the first phase of type I hypersensitivity reactions last?
late phase - infiltration of tissues with eosinophils, neutrophils, basophils, monocytes, and CD4+
TA cells. tissue destruction occurs (mucosal epithelial cell damage) What is the second
phase of type I hypersensitivity reactions?
2-24 hours after initial exposure WITHOUT additional exposure When does the second
phase of type I hypersensitivity reactions occur?
, mast cells
near blood vessels and nerves in subepithelial sites Which cells mediate type I
hypersensitivity reactions? Where are these cells found?
degranulation Mast cell activity is responsible for what cellular consequence?
cross-linking of IgE bound to IgE Fc receptors, complement factors C3a and C5a, physical
stimuli What are the ways in which mast cells can be triggered to initiate degranulation?
eosinophils The late phase response in type I hypersensitivity reactions is characterized by
a heavier involvement of what?
IL-5 produced by Th2 and mast cells What are eosinophils in the late phase of type I
hypersensitivity reactions recruited by?
release proteolytic enzymes, major basic protein, and eosinophilic cationic protein
produce LTC4
direct tissue damage and further mast cell degranulation
amplify and sustain response in absence of triggering antigen What do eosinophils do in
type I hypersensitivity reactions? What is the net result of these actions?
decreased infections in early childhood, as observed in 'developed' countries correlates with
increased incidence of type I hypersensitivity. reduced exposure to microbes is thought to reset
