TEST BANK
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
PlusBay.Plus
,TablewaofwaContents
Chapterwa01waPropertieswaandwaOverviewwaofwaImmunewaResponses 1
Chapterwa02waCellswaandwaTissueswaofwathewaImmunewaSystem 3
Chapterwa03waLeukocytewaCirculationwaandwaMigrationwaIntowaTissues 6
Chapterwa04waInnatewaImmunity 10
Chapterwa05waAntibodieswaandwaAntigens 17
Chapterwa06waAntigenwaPresentationwatowaTwaLymphocyteswaandwathewaFunctionswaofwaMajor
HistocompatibilitywaComplexwaMolecules 20
Chapterwa07waImmunewaReceptorswaandwaSignalwaTransduction 27
Chapterwa08waLymphocytewaDevelopmentwaandwaAntigenwaReceptorwaGenewaRearrangement 30
Chapterwa09waActivationwaofwaTwaLymphocytes 34
Chapterwa10waDifferentiationwaandwaFunctionswaofwaCD4+waEffectorwaTwaCells 38
Chapterwa11waDifferentiationwaandwaFunctionswaofwaCD8+waEffectorwaTwaCells 42
Chapterwa12waBwaCellwaActivationwaandwaAntibodywaProduction 46
Chapterwa13waEffectorwaMechanismswaofwaHumoralwaImmunity 52
Chapterwa14waSpecializedwaImmunitywaatwaEpithelialwaBarrierswaandwainwaImmunewaPrivilegedwaTissues 56
Chapterwa15waImmunologicwaTolerancewaandwaAutoimmunity 62
Chapterwa16waImmunitywatowaMicrobes 67
Chapterwa17waTransplantationwaImmunology 72
Chapterwa18waTumorwaImmunology 77
Chapterwa19waHypersensitivitywaDisorders 81
Chapterwa20waAllergy 86
Chapterwa21waPrimarywaandwaAcquiredwaImmunodeficiencies 89
PlusBay.Plus
,Chapterwa01:waPropertieswaandwaOverviewwaofwaImmunewaResponses
Abbas,waLichtman,waandwaPillai:waCellularwaandwaMolecularwaImmunology,wa10thwaEdition
MULTIPLEwaCHOICE
1. Thewaprincipalwafunctionwaofwathewaimmunewasystemwais:
a. Defensewaagainstwacancer
b. Repairwaofwainjuredwatissues
c. Defensewaagainstwamicrobialwainfections
d. Preventionwaofwainflammatorywadiseases
e. Protectionwaagainstwaenvironmentalwatoxins
ANS:w a w a C
Thewaimmunewasystemwahaswaevolvedwainwathewasettingwaofwaselectivewapressureswaimposedwa
bywamicrobialwainfections.waAlthoughwaimmunewaresponseswatowacancerwamaywaoccur,wathewac
onceptwathatwa“immunosurveillance”waagainstwacancerwaiswaawaprincipalwafunctionwaofwathewai
mmunewasystemwaiswacontroversial.waRepairwaofwainjuredwatissueswamaywabewaawasecondarywac
onsequencewaofwathewaimmunewaresponseswaandwainflammation.waAlthoughwathewaimmunewas
ystemwahaswaregulatorywafeatureswathatwaarewaneededwatowapreventwaexcessivewainflammation,
wapreventionwaofwainflammatorywadiseaseswaiswanotwaawaprimarywafunction.waThewaimmunewas
ystemwacanwaprotectwaagainstwamicrobialwatoxins,wabutwaitwagenerallywadoeswanotwaofferwaprote
ctionwaagainstwatoxinswaofwanonbiologicwaorigin.
2. Whichwaofwathewafollowingwainfectiouswadiseaseswawaswapreventedwabywathewafir
stwasuccessfulwavaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:w a w a C
Inwa1798,waEdwardwaJennerwareportedwathewafirstwaintentionalwasuccessfulwavaccination,waw
hichwawaswaagainstwasmallpoxwainwaawaboy,wausingwamaterialwafromwathewacowpoxwapustule
swaofwaawamilkmaid.waInwa1980,wasmallpoxwawaswareportedwatowabewaeradicatedwaworldwide
wabywaawavaccinationwaprogram.waEffectivewavaccineswaagainstwatetanuswatoxin,warubellawav
irus,waandwapolioviruswawerewadevelopedwainwathewa20thwacenturywaandwaarewawidelywaused
.waTherewaiswanowaeffectivewavaccinewaagainstwaMycobacteriumwatuberculosis.
3. Whichwaofwathewafollowingwaiswaawauniquewapropertywaofwathewaadaptivewaimmunewasystem?
a. Highlywadiversewarepertoirewaofwaspecificitieswaforwaantigens
b. Self-nonselfwa discrimination
c. Recognitionwaofwamicrobialwastructureswabywabothwacell-associatedwaandwasolublewareceptors
d. Protectionwaagainstwaviralwainfections
e. Responseswathatwahavewathewasamewakineticswaandwamagnitudewaonwarepeatedwaex
posurewatowathewasamewamicrobe
ANS:w a w a A
PlusBay.Plus
, HighlywadiversewarepertoireswaofwaspecificitieswaforwaantigenswaarewafoundwaonlywainwaTwaa
ndwaBwalymphocytes,wawhichwaarewathewacentralwacellularwacomponentswaofwathewaadaptive
waimmunewasystem.waBothwathewainnatewaandwathewaadaptivewaimmunewasystemswausewacell-
associatedwaandwasolublewareceptorswatowarecognizewamicrobes,wadisplaywasomewadegreewao
fwaself-
nonselfwadiscrimination,waandwaprotectwaagainstwaviruses.waOnwarepeatedwaexposurewatowath
ewasamewamicrobe,wathewaadaptivewaimmunewaresponsewabecomeswamorewarapidwaandwaofwa
greaterwamagnitude;wathiswaiswathewamanifestationwaofwamemory.
4. AntibodieswaandwaTwalymphocyteswaarewathewarespectivewamediatorswaofwawhichw
atwowatypeswaofwaimmunity?
a. Innatewaandwaadaptive
b. Passivewaandwaactive
c. Specificwaandwanonspecific
d. Humoralwaandwacell-mediated
e. Adultwaandwaneonatal
ANS:w a w a D
BothwaBwaandwaTwalymphocyteswaarewaprincipalwacomponentswaofwaadaptivewaimmunity.waB
walymphocyteswaproducewaantibodies,wawhichwaarewathewarecognitionwaandwaeffectorwamolec
uleswaofwahumoralwaimmunewaresponseswatowaextracellularwapathogens.waTwacellswarecogniz
ewaandwapromotewaeradicationwaofwaintracellularwapathogenswainwacell-
mediatedwaimmunity.waPassivewaandwaactivewaimmunitywabothwacanwabewamediatedwabywaeit
herwaBwaorwaTwalymphocytes.waSpecificwaimmunitywaiswaanotherwatermwaforwaadaptivewaimm
unity.waBothwaBwaandwaTwalymphocyteswaparticipatewainwaadultwaadaptivewaimmunitywabutwa
arewastillwadevelopingwainwathewaneonatalwaperiod.
5. ThewatwowamajorwafunctionalwaclasseswaofwaeffectorwaTwalymphocyteswaare:
a. HelperwaTwalymphocyteswaandwacytotoxicwaTwalymphocytes
b. NaturalwakillerwacellswaandwacytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorywaTwacellswaandwaeffectorwaTwacells
d. Helperwacellswaandwaantigen-presentingwacells
e. CytotoxicwaTwalymphocyteswaandwatargetwacells
ANS:w a w a A
Twacellswacanwabewaclassifiedwaintowaeffectorwasubsetswathatwaperformwadifferentwaeffectorwaf
unctions.waMostwaeffectorwaTwacellswaarewaeitherwahelperwaTwalymphocytes,wawhichwaenhan
cewathewaresponseswaofwaotherwaimmunewacells,waincludingwaphagocyteswaandwaBwacells,wat
owainfections,waorwacytotoxicwaTwalymphocytes,wawhichwadirectlywakillwainfectedwacells.waN
aturalwakillerwacellswaarewanotwaTwalymphocytes.
Antigen-
presentingwacellswausuallywaarewanotwaTwacells.waMemorywaTwacellswaarewanotwaeffectorwaTwacell
s.
6. Whichwaofwathewafollowingwacellwatypeswaiswarequiredwaforwaallwaadaptivewahumoralwaimmunewa
responses?
a. Naturalwakillerwacells
b. Dendriticwacells
c. CytolyticwaTwalymphocytes
d. Bwalymphocytes
e. HelperwaTwalymphocytes
ANS:w a w a D
Humoralwaimmunewaresponseswaarewaantibody-
PlusBay.Plus
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
PlusBay.Plus
,TablewaofwaContents
Chapterwa01waPropertieswaandwaOverviewwaofwaImmunewaResponses 1
Chapterwa02waCellswaandwaTissueswaofwathewaImmunewaSystem 3
Chapterwa03waLeukocytewaCirculationwaandwaMigrationwaIntowaTissues 6
Chapterwa04waInnatewaImmunity 10
Chapterwa05waAntibodieswaandwaAntigens 17
Chapterwa06waAntigenwaPresentationwatowaTwaLymphocyteswaandwathewaFunctionswaofwaMajor
HistocompatibilitywaComplexwaMolecules 20
Chapterwa07waImmunewaReceptorswaandwaSignalwaTransduction 27
Chapterwa08waLymphocytewaDevelopmentwaandwaAntigenwaReceptorwaGenewaRearrangement 30
Chapterwa09waActivationwaofwaTwaLymphocytes 34
Chapterwa10waDifferentiationwaandwaFunctionswaofwaCD4+waEffectorwaTwaCells 38
Chapterwa11waDifferentiationwaandwaFunctionswaofwaCD8+waEffectorwaTwaCells 42
Chapterwa12waBwaCellwaActivationwaandwaAntibodywaProduction 46
Chapterwa13waEffectorwaMechanismswaofwaHumoralwaImmunity 52
Chapterwa14waSpecializedwaImmunitywaatwaEpithelialwaBarrierswaandwainwaImmunewaPrivilegedwaTissues 56
Chapterwa15waImmunologicwaTolerancewaandwaAutoimmunity 62
Chapterwa16waImmunitywatowaMicrobes 67
Chapterwa17waTransplantationwaImmunology 72
Chapterwa18waTumorwaImmunology 77
Chapterwa19waHypersensitivitywaDisorders 81
Chapterwa20waAllergy 86
Chapterwa21waPrimarywaandwaAcquiredwaImmunodeficiencies 89
PlusBay.Plus
,Chapterwa01:waPropertieswaandwaOverviewwaofwaImmunewaResponses
Abbas,waLichtman,waandwaPillai:waCellularwaandwaMolecularwaImmunology,wa10thwaEdition
MULTIPLEwaCHOICE
1. Thewaprincipalwafunctionwaofwathewaimmunewasystemwais:
a. Defensewaagainstwacancer
b. Repairwaofwainjuredwatissues
c. Defensewaagainstwamicrobialwainfections
d. Preventionwaofwainflammatorywadiseases
e. Protectionwaagainstwaenvironmentalwatoxins
ANS:w a w a C
Thewaimmunewasystemwahaswaevolvedwainwathewasettingwaofwaselectivewapressureswaimposedwa
bywamicrobialwainfections.waAlthoughwaimmunewaresponseswatowacancerwamaywaoccur,wathewac
onceptwathatwa“immunosurveillance”waagainstwacancerwaiswaawaprincipalwafunctionwaofwathewai
mmunewasystemwaiswacontroversial.waRepairwaofwainjuredwatissueswamaywabewaawasecondarywac
onsequencewaofwathewaimmunewaresponseswaandwainflammation.waAlthoughwathewaimmunewas
ystemwahaswaregulatorywafeatureswathatwaarewaneededwatowapreventwaexcessivewainflammation,
wapreventionwaofwainflammatorywadiseaseswaiswanotwaawaprimarywafunction.waThewaimmunewas
ystemwacanwaprotectwaagainstwamicrobialwatoxins,wabutwaitwagenerallywadoeswanotwaofferwaprote
ctionwaagainstwatoxinswaofwanonbiologicwaorigin.
2. Whichwaofwathewafollowingwainfectiouswadiseaseswawaswapreventedwabywathewafir
stwasuccessfulwavaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS:w a w a C
Inwa1798,waEdwardwaJennerwareportedwathewafirstwaintentionalwasuccessfulwavaccination,waw
hichwawaswaagainstwasmallpoxwainwaawaboy,wausingwamaterialwafromwathewacowpoxwapustule
swaofwaawamilkmaid.waInwa1980,wasmallpoxwawaswareportedwatowabewaeradicatedwaworldwide
wabywaawavaccinationwaprogram.waEffectivewavaccineswaagainstwatetanuswatoxin,warubellawav
irus,waandwapolioviruswawerewadevelopedwainwathewa20thwacenturywaandwaarewawidelywaused
.waTherewaiswanowaeffectivewavaccinewaagainstwaMycobacteriumwatuberculosis.
3. Whichwaofwathewafollowingwaiswaawauniquewapropertywaofwathewaadaptivewaimmunewasystem?
a. Highlywadiversewarepertoirewaofwaspecificitieswaforwaantigens
b. Self-nonselfwa discrimination
c. Recognitionwaofwamicrobialwastructureswabywabothwacell-associatedwaandwasolublewareceptors
d. Protectionwaagainstwaviralwainfections
e. Responseswathatwahavewathewasamewakineticswaandwamagnitudewaonwarepeatedwaex
posurewatowathewasamewamicrobe
ANS:w a w a A
PlusBay.Plus
, HighlywadiversewarepertoireswaofwaspecificitieswaforwaantigenswaarewafoundwaonlywainwaTwaa
ndwaBwalymphocytes,wawhichwaarewathewacentralwacellularwacomponentswaofwathewaadaptive
waimmunewasystem.waBothwathewainnatewaandwathewaadaptivewaimmunewasystemswausewacell-
associatedwaandwasolublewareceptorswatowarecognizewamicrobes,wadisplaywasomewadegreewao
fwaself-
nonselfwadiscrimination,waandwaprotectwaagainstwaviruses.waOnwarepeatedwaexposurewatowath
ewasamewamicrobe,wathewaadaptivewaimmunewaresponsewabecomeswamorewarapidwaandwaofwa
greaterwamagnitude;wathiswaiswathewamanifestationwaofwamemory.
4. AntibodieswaandwaTwalymphocyteswaarewathewarespectivewamediatorswaofwawhichw
atwowatypeswaofwaimmunity?
a. Innatewaandwaadaptive
b. Passivewaandwaactive
c. Specificwaandwanonspecific
d. Humoralwaandwacell-mediated
e. Adultwaandwaneonatal
ANS:w a w a D
BothwaBwaandwaTwalymphocyteswaarewaprincipalwacomponentswaofwaadaptivewaimmunity.waB
walymphocyteswaproducewaantibodies,wawhichwaarewathewarecognitionwaandwaeffectorwamolec
uleswaofwahumoralwaimmunewaresponseswatowaextracellularwapathogens.waTwacellswarecogniz
ewaandwapromotewaeradicationwaofwaintracellularwapathogenswainwacell-
mediatedwaimmunity.waPassivewaandwaactivewaimmunitywabothwacanwabewamediatedwabywaeit
herwaBwaorwaTwalymphocytes.waSpecificwaimmunitywaiswaanotherwatermwaforwaadaptivewaimm
unity.waBothwaBwaandwaTwalymphocyteswaparticipatewainwaadultwaadaptivewaimmunitywabutwa
arewastillwadevelopingwainwathewaneonatalwaperiod.
5. ThewatwowamajorwafunctionalwaclasseswaofwaeffectorwaTwalymphocyteswaare:
a. HelperwaTwalymphocyteswaandwacytotoxicwaTwalymphocytes
b. NaturalwakillerwacellswaandwacytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. MemorywaTwacellswaandwaeffectorwaTwacells
d. Helperwacellswaandwaantigen-presentingwacells
e. CytotoxicwaTwalymphocyteswaandwatargetwacells
ANS:w a w a A
Twacellswacanwabewaclassifiedwaintowaeffectorwasubsetswathatwaperformwadifferentwaeffectorwaf
unctions.waMostwaeffectorwaTwacellswaarewaeitherwahelperwaTwalymphocytes,wawhichwaenhan
cewathewaresponseswaofwaotherwaimmunewacells,waincludingwaphagocyteswaandwaBwacells,wat
owainfections,waorwacytotoxicwaTwalymphocytes,wawhichwadirectlywakillwainfectedwacells.waN
aturalwakillerwacellswaarewanotwaTwalymphocytes.
Antigen-
presentingwacellswausuallywaarewanotwaTwacells.waMemorywaTwacellswaarewanotwaeffectorwaTwacell
s.
6. Whichwaofwathewafollowingwacellwatypeswaiswarequiredwaforwaallwaadaptivewahumoralwaimmunewa
responses?
a. Naturalwakillerwacells
b. Dendriticwacells
c. CytolyticwaTwalymphocytes
d. Bwalymphocytes
e. HelperwaTwalymphocytes
ANS:w a w a D
Humoralwaimmunewaresponseswaarewaantibody-
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