ONS/ONCC CHEMOTHERAPY
IMMUNOTHERAPY CERTIFICATE EXAM
2025 ACTUAL EXAM
Define mutations Correct Answer Variations in the nucleotide
sequence of a gene
3 main goals of treatment: Correct Answer Cure
Control
Palliation
Define neoadjuvant therapy Correct Answer Treatment is given
prior to surgery to shrink the tumor
Define adjuvant therapy Correct Answer Additional cancer
treatment given after the primary treatment to lower the risk that
the cancer reoccur
Define conditioning/preparative therapy Correct Answer
Treatments used to prepare a patient for stem cell transplantation
2 types of conditioning therapies: Correct Answer Myeloablative
,Nonmyeloablative
Define dose density Correct Answer Drug dose per unit of time
Define dose intensity Correct Answer Amount of drug delivered
over time
How is relative dose intensity (RDI) calculated? Correct Answer
By comparing the dose that the patient ACTUALLY received to
the planned dose of the standard regimen
How do alkylating agents work? Correct Answer By causing a
break in the DNA helix strand, interfering with DNA replication and
causing cell death
3 subcategories of alkylating agents: Correct Answer 1. Nitrogen
mustards
2. Platinum-based agents (do not possess an alkyl group but still
termed alkylating agents as they work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: Correct Answer
Nitrogen mustards
,Common alkylating agents: Correct Answer Cyclophosphamide
(Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: Correct Answer Cisplatin
(Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? Correct Answer Able
to cross the blood-brain barrier; can be effective in treating some
brain tumors
Common nitrosoureas agents: Correct Answer Carmustine
(BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: Correct Answer
Carboplatin
These agents are typically categorized as highly emetogenic:
Correct Answer 1. Alkylating agents
2. Nitrosoureas
, Pre-administration labs for alkylating agents and nitrosoureas:
Correct Answer BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? Correct Answer Bladder
protectant with administration of cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and
consuming cold fluids for 3-4 days following treatment Correct
Answer Oxaliplatin
How do antimetabolites function? Correct Answer By blocking
DNA and RNA growth by interfering with enzymes needed for
normal cell metabolism
Antimetabolites work in the ___ phase. Correct Answer S
What types of cells are best affected by antimetabolites? Correct
Answer Cells with high division rates
Common side effects of antimetabolites: Correct Answer
Myelosuppression
IMMUNOTHERAPY CERTIFICATE EXAM
2025 ACTUAL EXAM
Define mutations Correct Answer Variations in the nucleotide
sequence of a gene
3 main goals of treatment: Correct Answer Cure
Control
Palliation
Define neoadjuvant therapy Correct Answer Treatment is given
prior to surgery to shrink the tumor
Define adjuvant therapy Correct Answer Additional cancer
treatment given after the primary treatment to lower the risk that
the cancer reoccur
Define conditioning/preparative therapy Correct Answer
Treatments used to prepare a patient for stem cell transplantation
2 types of conditioning therapies: Correct Answer Myeloablative
,Nonmyeloablative
Define dose density Correct Answer Drug dose per unit of time
Define dose intensity Correct Answer Amount of drug delivered
over time
How is relative dose intensity (RDI) calculated? Correct Answer
By comparing the dose that the patient ACTUALLY received to
the planned dose of the standard regimen
How do alkylating agents work? Correct Answer By causing a
break in the DNA helix strand, interfering with DNA replication and
causing cell death
3 subcategories of alkylating agents: Correct Answer 1. Nitrogen
mustards
2. Platinum-based agents (do not possess an alkyl group but still
termed alkylating agents as they work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: Correct Answer
Nitrogen mustards
,Common alkylating agents: Correct Answer Cyclophosphamide
(Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: Correct Answer Cisplatin
(Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? Correct Answer Able
to cross the blood-brain barrier; can be effective in treating some
brain tumors
Common nitrosoureas agents: Correct Answer Carmustine
(BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: Correct Answer
Carboplatin
These agents are typically categorized as highly emetogenic:
Correct Answer 1. Alkylating agents
2. Nitrosoureas
, Pre-administration labs for alkylating agents and nitrosoureas:
Correct Answer BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? Correct Answer Bladder
protectant with administration of cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and
consuming cold fluids for 3-4 days following treatment Correct
Answer Oxaliplatin
How do antimetabolites function? Correct Answer By blocking
DNA and RNA growth by interfering with enzymes needed for
normal cell metabolism
Antimetabolites work in the ___ phase. Correct Answer S
What types of cells are best affected by antimetabolites? Correct
Answer Cells with high division rates
Common side effects of antimetabolites: Correct Answer
Myelosuppression
