NR 565 MIDTERM ACTUAL EXAM TEST/
2025-2026 ACTUAL MIDTERM TEST
GRADED A+
What are the key responsibilities of prescribing? Correct Answer A
sound understanding of drugs and the conditions that they are
used to manage
Be deliberate in decision-making process
Do not prescribe for family or friends
Document thorough history and physical for the records, including
education provided on drug
Have a documented plan for monitoring and titration
What should be used in making prescribing decisions? Correct
Answer Cost, follow current guidelines, availability, interactions,
side effects, allergies, hepatic/renal function, need for monitoring,
special populations
PK and PD changes in older adults and how that affects how you
prescribe? Correct Answer Very high risk of adverse drug
reactions and drug-drug interactions
D/t altered PK, multiple and severe illnesses, polypharmacy, poor
adherence
,Beer's Criteria Correct Answer List of potentially inappropriate
medications to use in the older populations
Updated annually
Prescribers ultimately decide whether to prescribe or not
Impacts/outcomes of polypharmacy? Correct Answer Increased
ADRs and drug-drug interactions
What are CYP450? Correct Answer Enzymes responsible for drug
metabolism (biotransformation)-oxidization, reduction, hydrolyzed
to promote renal dug excretion
Hepatic enzyme system, composed of 12 enzyme families
What do CYP450 enzymes do? Correct Answer Promote drug
excretion by making them more "excretable"--hydrophilic/water
soluble and charged (ion)
Inactivate drugs, increase therapeutic action through metabolism,
activate a prodrug, decrease drug toxicity
CYP450 inhibitor examples? Correct Answer VISA credit card
debt inhibits spending on designers like CK to look GQ
Valproate
Isoniazid
, Sulfonamides
Amiodarone
Chloramphenicol
Ketoconzaole
Grapefruit juice
Quinidine
What do CYP450 inhibitors do? Correct Answer Decrease the
rate of metabolism
Act on liver through process of inhibition
Slows rate of metabolism, increases active drug accumulation
which can lead to adverse reactions and drug toxicity
What do CYP450 inhibitors do if not used correctly? Correct
Answer Can lead to adverse effects and drug toxicity
What happens when someone has a poor metabolism
phenotype? Correct Answer Associated with accumulation of
drugs in the body and they may experience drug toxicity
What does the US FDA regulate when it comes to medications?
Correct Answer Regulates safety and effectiveness of drugs sold
in US
2025-2026 ACTUAL MIDTERM TEST
GRADED A+
What are the key responsibilities of prescribing? Correct Answer A
sound understanding of drugs and the conditions that they are
used to manage
Be deliberate in decision-making process
Do not prescribe for family or friends
Document thorough history and physical for the records, including
education provided on drug
Have a documented plan for monitoring and titration
What should be used in making prescribing decisions? Correct
Answer Cost, follow current guidelines, availability, interactions,
side effects, allergies, hepatic/renal function, need for monitoring,
special populations
PK and PD changes in older adults and how that affects how you
prescribe? Correct Answer Very high risk of adverse drug
reactions and drug-drug interactions
D/t altered PK, multiple and severe illnesses, polypharmacy, poor
adherence
,Beer's Criteria Correct Answer List of potentially inappropriate
medications to use in the older populations
Updated annually
Prescribers ultimately decide whether to prescribe or not
Impacts/outcomes of polypharmacy? Correct Answer Increased
ADRs and drug-drug interactions
What are CYP450? Correct Answer Enzymes responsible for drug
metabolism (biotransformation)-oxidization, reduction, hydrolyzed
to promote renal dug excretion
Hepatic enzyme system, composed of 12 enzyme families
What do CYP450 enzymes do? Correct Answer Promote drug
excretion by making them more "excretable"--hydrophilic/water
soluble and charged (ion)
Inactivate drugs, increase therapeutic action through metabolism,
activate a prodrug, decrease drug toxicity
CYP450 inhibitor examples? Correct Answer VISA credit card
debt inhibits spending on designers like CK to look GQ
Valproate
Isoniazid
, Sulfonamides
Amiodarone
Chloramphenicol
Ketoconzaole
Grapefruit juice
Quinidine
What do CYP450 inhibitors do? Correct Answer Decrease the
rate of metabolism
Act on liver through process of inhibition
Slows rate of metabolism, increases active drug accumulation
which can lead to adverse reactions and drug toxicity
What do CYP450 inhibitors do if not used correctly? Correct
Answer Can lead to adverse effects and drug toxicity
What happens when someone has a poor metabolism
phenotype? Correct Answer Associated with accumulation of
drugs in the body and they may experience drug toxicity
What does the US FDA regulate when it comes to medications?
Correct Answer Regulates safety and effectiveness of drugs sold
in US
