and Molecular Diagnostics,
8th Edition by Nader Rifai, PhD
Chapters 1 - 49
,TietzeFundamentalseofeClinicaleChemistryeandeMoleculareDiagnosticse8the EditioneTesteBank
Tableeofecontents:
I.ePrincipleseOfeLaboratoryeMedicine
Chaptere1.eClinicaleChemistry,eMoleculareDiagnostics,eandeLaboratoryeMedicine
Chaptere2.eSelectioneandeAnalyticaleEvaluationeofeMethodse—eWitheStatisticaleTechniques
Chaptere3.eClinicaleEvaluationeofeMethods
Chaptere4.eEvidence-BasedeLaboratoryeMedicine
Chaptere5.eEstablishmenteandeUseeofeReferenceeValues
Chaptere6.eSpecimeneCollection,eProcessing,eandeOtherePreanalyticaleVariables
Chaptere7.eQualityeManagement
II.eAnalyticaleTechniqueseAndeInstrumentation
Chaptere8.ePrincipleseofeBasiceTechniqueseandeLaboratoryeSafety
Chaptere9.eOpticaleTechniques
Chaptere10.eElectrochemistryeandeChemicaleSensors
Chaptere11.eElectrophoresis
Chaptere12.eChromatography
Chaptere13.eMasseSpectrometry
Chaptere14.eEnzymeeandeRateeAnalyses
Chaptere15.eImmunochemicaleTechniques
Chaptere16eAutomation
Chaptere17.ePoint-of-CareeInstrumentation
III.e Analytes
Chaptere18.eAminoeAcids,ePeptides,eandeProteins
Chaptere19.eSerumeEnzymes
Chaptere20.eTumoreMarkerseandeCancereGenes
Chaptere21.eKidneyeFunctioneTestse—eCreatinine,eGFR,eUrea,eandeUriceAcid
Chaptere22.eCarbohydrates
Chaptere23.eLipids,eLipoproteins,eApolipoproteins,eandeOthereCardiaceRiskeFactors
Chaptere24.eElectrolyteseandeBloodeGases
Chaptere25.eHormones
Chaptere26.e CatecholamineseandeSerotonin
Chaptere27.e Vitamins,eTraceeElements,eNutritionaleAssessment
Chaptere28.eHemoglobin,eIron,eandeBilirubin
Chaptere29.ePorphyrinseandePorphyrias
Chaptere30.eTherapeuticeDrugseandeTheireManagement
Chaptere31.eClinicaleToxicology
Chaptere32.e ToxiceMetals
IV.e Pathophysiology
Chaptere33.eDiabetes
,Chaptere34.e CardiovasculareDisease
Chaptere35.eKidneyeDisease
Chaptere36.e PhysiologyeandeDisorderseofeWater,eElectrolyte,eandeAcid-BaseeMetabolism
Chaptere37.e LivereDisease
Chaptere38.e GastrointestinaleandePancreaticeDiseases
Chaptere39.e DisorderseofeBoneeandeMineraleMetabolism
Chaptere40.e DisorderseofetheePituitaryeGland
Chaptere41.e DisorderseofetheeAdrenaleCortex
Chaptere42.e ThyroideDisorders
Chaptere43.e Reproduction-RelatedeDisorders
Chaptere44.e PregnancyeandePrenataleTesting
Chaptere45.e NewborneScreeningeandeInborneErrorseofeMetabolism
Chaptere46.ePharmacogenetics
V.e MoleculareDiagnostics
Chaptere47.ePrincipleseofeMoleculareBiology
Chaptere48.eNucleiceAcideTechniqueseandeApplications
Chaptere49.eGenomeseandeNucleiceAcideAlterations
, Chaptere01:eClinicaleChemistry,eMoleculareDiagnostics,eandeLaboratoryeMedicineeTesteBank
MULTIPLEeCHOICE
1. Aneindividualeworkingeineaeclinicalechemistryelaboratoryeisemarriedetoeaesaleserepresentativeew
hoeworkseforeaecompanyethatesellsechemistryelaboratoryesupplies.eWhenetheelaboratoryemaneager
erequestseaelisteofeneededesupplies,ecosteofesupplies,eandevendors,ethiseindividualeonlyrecoemmen
dsetheespouse’secompanyeasetheevendor.eThiseiseconsideredetoebeea(n):
a. accountingeissue.
b. possibleeconflicteofeinterest.
c. maintenanceeofeconfidentialityeissue.
d. problemewitheresourceeallocation.
ANS:e B
Concernehasebeeneraisedeoveretheeinterrelationshipsebetweenepractitionerseinetheemedicalefieldean
decommercialesupplierseofedrugs,edevices,eequipment,eetc.,etoetheemedicaleprofession.
Similarly,erelationshipsehaveebeenescrutinizedebetweeneclinicalelaboratorianseandemanufacturerese
andeproviderseofediagnosticeequipmenteandesupplies.eTheseeconcernseledetheeNationaleInstituteeseo
feHealthe(NIH)eine1995etoerequireeofficialeinstitutionalerevieweofefinancialedisclosureebyereseearche
rseandemanagementeofesituationseinewhichedisclosureSindicatesepotentialconflictseofeintereest.
DIF: 1 REF:e e Pagee4-5 OBJ:e 6e|e7
2. Aepatientevisitseherephysicianestatingethatehereprescribedepainkillereisenoteworkingetoereduceetehee
painefollowingehererecentesurgery.eAefriendeofetheSpatienteclaimsethatetheesameepainkiller“ework
edewonders”etoereduceeherepaineafteretheesameesurgery.eTheephysicianestatesethatetheedifeferencee
inetheeeffecteofetheedrugemightebeecausedeby
,ewhicheisestudiedeinepharmacogenetics.
a. epidemiology
b. aneinheritededisease
c. aeconflicteofeinterest
d. aegeneticevariationeinedrug-metabolizingeenzymes
ANS:e D
Pharmacogeneticseisetheestudyeofetheegeneticevariationeofedrugemetabolismebetweeniendividual
s.
DIF: 1 REF:e e Pagee3 OBJ:e 1
3. Johneworkseineaemolecularediagnosticselaboratoryeandereceiveseaebloodesampleethatehasetheenea
meeofeaecloseefriendeprintedSonetheebar-
codedelabel.eTheegeneticetestethateiseorderedeonethefriend’sesampleewouldeprovideediagnosticeinfor
mationeabouteaedisorderethatehaseaepooreprognosis,eandetheetesteiseusuallyeperformedebyeJohn.eHeea
skseaefelloweemployeeetoeanalyzetheesampleeforehimeandenotedivulgeetheeresults.eThiseethicaleissu
eSconcerns:
a. confidentialityeofepatientegeneticeandemedicaleinformation.
b. aeconflicteofeinterest.
c. resourceeallocation.
d. diagnosticeaccuracy.