TEST BANKx
Cellular and Molecular Immunology
x x x
Abul Abbas, Andrew Lichtman, and Shiv Pillai
x x x x x x
10th Edition
x
,Table of Contents
x x
Chapter x01 xProperties xand xOverview xof xImmune xResponses 1
Chapter x02 xCells xand xTissues xof xthe xImmune xSystem 3
Chapter x03 xLeukocyte xCirculation xand xMigration xInto xTissues 6
Chapter x04 xInnate xImmunity 10
Chapter x05 xAntibodies xand xAntigens 17
Chapter x06 xAntigen xPresentation xto xT xLymphocytes xand xthe xFunctions xof xMajor
Histocompatibility xComplex xMolecules 20
Chapter x07 xImmune xReceptors xand xSignal xTransduction 27
Chapter x08 xLymphocyte xDevelopment xand xAntigen xReceptor xGene xRearrangement 30
Chapter x09 xActivation xof xT xLymphocytes 34
Chapter x10 xDifferentiation xand xFunctions xof xCD4+ xEffector xT xCells 38
Chapter x11 xDifferentiation xand xFunctions xof xCD8+ xEffector xT xCells 42
Chapter x12 xB xCell xActivation xand xAntibody xProduction 46
Chapter x13 xEffector xMechanisms xof xHumoral xImmunity 52
Chapter x14 xSpecialized xImmunity xat xEpithelial xBarriers xand xin xImmune xPrivileged xTissues 56
Chapter x15 xImmunologic xTolerance xand xAutoimmunity 62
Chapter x16 xImmunity xto xMicrobes 67
Chapter x17 xTransplantation xImmunology 72
Chapter x18 xTumor xImmunology 77
Chapter x19 xHypersensitivity xDisorders 81
Chapter x20 xAllergy 86
Chapter x21 xPrimary xand xAcquired xImmunodeficiencies 89
,Chapter 01: Properties and Overview of Immune Responses
x x x x x x x
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
x x x x x x x x x
MULTIPLE xCHOICE
1. The xprincipal xfunction xof xthe ximmune xsystem xis:
a. Defense xagainst xcancer
b. Repair xof xinjured xtissues
c. Defense xagainst xmicrobial xinfections
d. Prevention xof xinflammatory xdiseases
e. Protection xagainst xenvironmental xtoxins
ANS: x x C
The ximmune xsystem xhas xevolved xin xthe xsetting xof xselective xpressures ximposed xby xmicrobial
xinfections. xAlthough ximmune xresponses xto xcancer xmay xoccur, xthe xconcept xthat
x“immunosurveillance” xagainst xcancer xis xa xprincipal xfunction xof xthe ximmune xsystem xis
xcontroversial. xRepair xof xinjured xtissues xmay xbe xa xsecondary xconsequence xof xthe ximmune
xresponses xand xinflammation. xAlthough xthe ximmune xsystem xhas xregulatory xfeatures xthat xare
xneeded xto xprevent xexcessive xinflammation, xprevention xof xinflammatory xdiseases xis xnot xa
xprimary xfunction. xThe ximmune xsystem xcan xprotect xagainst xmicrobial xtoxins, xbut xit xgenerally
xdoes xnot xoffer xprotection xagainst xtoxins xof xnonbiologic xorigin.
2. Which xof xthe xfollowing xinfectious xdiseases xwas xprevented xby xthe xfirst
xsuccessful xvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: x x C
In x1798, xEdward xJenner xreported xthe xfirst xintentional xsuccessful xvaccination, xwhich xwas
xagainst xsmallpox xin xa xboy, xusing xmaterial xfrom xthe xcowpox xpustules xof xa xmilkmaid. xIn
x1980, xsmallpox xwas xreported xto xbe xeradicated xworldwide xby xa xvaccination xprogram.
xEffective xvaccines xagainst xtetanus xtoxin, xrubella xvirus, xand xpoliovirus xwere xdeveloped xin
xthe x20th xcentury xand xare xwidely xused. xThere xis xno xeffective xvaccine xagainst
xMycobacterium xtuberculosis.
3. Which xof xthe xfollowing xis xa xunique xproperty xof xthe xadaptive ximmune xsystem?
a. Highly xdiverse xrepertoire xof xspecificities xfor xantigens
b. Self-nonself xdiscrimination
c. Recognition xof xmicrobial xstructures xby xboth xcell-associated xand xsoluble xreceptors
d. Protection xagainst xviral xinfections
e. Responses xthat xhave xthe xsame xkinetics xand xmagnitude xon xrepeated xexposure xto
xthe xsame xmicrobe
ANS: x x A
, Highly xdiverse xrepertoires xof xspecificities xfor xantigens xare xfound xonly xin xT xand xB
xlymphocytes, xwhich xare xthe xcentral xcellular xcomponents xof xthe xadaptive ximmune xsystem.
xBoth xthe xinnate xand xthe xadaptive ximmune xsystems xuse xcell-associated xand xsoluble
xreceptors xto xrecognize xmicrobes, xdisplay xsome xdegree xof xself-nonself xdiscrimination, xand
xprotect xagainst xviruses. xOn xrepeated xexposure xto xthe xsame xmicrobe, xthe xadaptive ximmune
xresponse xbecomes xmore xrapid xand xof xgreater xmagnitude; xthis xis xthe xmanifestation xof
xmemory.
4. Antibodies xand xT xlymphocytes xare xthe xrespective xmediators xof xwhich xtwo xtypes
xof ximmunity?
a. Innate xand xadaptive
b. Passive xand xactive
c. Specific xand xnonspecific
d. Humoral xand xcell-mediated
e. Adult xand xneonatal
ANS: x x D
Both xB xand xT xlymphocytes xare xprincipal xcomponents xof xadaptive ximmunity. xB
xlymphocytes xproduce xantibodies, xwhich xare xthe xrecognition xand xeffector xmolecules xof
xhumoral ximmune xresponses xto xextracellular xpathogens. xT xcells xrecognize xand xpromote
xeradication xof xintracellular xpathogens xin xcell-mediated ximmunity. xPassive xand xactive
ximmunity xboth xcan xbe xmediated xby xeither xB xor xT xlymphocytes. xSpecific ximmunity xis
xanother xterm xfor xadaptive ximmunity. xBoth xB xand xT xlymphocytes xparticipate xin xadult
xadaptive ximmunity xbut xare xstill xdeveloping xin xthe xneonatal xperiod.
5. The xtwo xmajor xfunctional xclasses xof xeffector xT xlymphocytes xare:
a. Helper xT xlymphocytes xand xcytotoxic xT xlymphocytes
b. Natural xkiller xcells xand xcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. Memory xT xcells xand xeffector xT xcells
d. Helper xcells xand xantigen-presenting xcells
e. Cytotoxic xT xlymphocytes xand xtarget xcells
ANS: x x A
T xcells xcan xbe xclassified xinto xeffector xsubsets xthat xperform xdifferent xeffector xfunctions.
xMost xeffector xT xcells xare xeither xhelper xT xlymphocytes, xwhich xenhance xthe xresponses xof
xother ximmune xcells, xincluding xphagocytes xand xB xcells, xto xinfections, xor xcytotoxic xT
xlymphocytes, xwhich xdirectly xkill xinfected xcells. xNatural xkiller xcells xare xnot xT
xlymphocytes.
Antigen-presenting xcells xusually xare xnot xT xcells. xMemory xT xcells xare xnot xeffector xT xcells.
6. Which xof xthe xfollowing xcell xtypes xis xrequired xfor xall xadaptive xhumoral ximmune xresponses?
a. Natural xkiller xcells
b. Dendritic xcells
c. Cytolytic xT xlymphocytes
d. B xlymphocytes
e. Helper xT xlymphocytes
ANS: x x D
Humoral ximmune xresponses xare xantibody-mediated ximmune xresponses, xand xall xantibodies
xare xmade xby xB xlymphocytes xand xno xother xcell xtype.
Cellular and Molecular Immunology
x x x
Abul Abbas, Andrew Lichtman, and Shiv Pillai
x x x x x x
10th Edition
x
,Table of Contents
x x
Chapter x01 xProperties xand xOverview xof xImmune xResponses 1
Chapter x02 xCells xand xTissues xof xthe xImmune xSystem 3
Chapter x03 xLeukocyte xCirculation xand xMigration xInto xTissues 6
Chapter x04 xInnate xImmunity 10
Chapter x05 xAntibodies xand xAntigens 17
Chapter x06 xAntigen xPresentation xto xT xLymphocytes xand xthe xFunctions xof xMajor
Histocompatibility xComplex xMolecules 20
Chapter x07 xImmune xReceptors xand xSignal xTransduction 27
Chapter x08 xLymphocyte xDevelopment xand xAntigen xReceptor xGene xRearrangement 30
Chapter x09 xActivation xof xT xLymphocytes 34
Chapter x10 xDifferentiation xand xFunctions xof xCD4+ xEffector xT xCells 38
Chapter x11 xDifferentiation xand xFunctions xof xCD8+ xEffector xT xCells 42
Chapter x12 xB xCell xActivation xand xAntibody xProduction 46
Chapter x13 xEffector xMechanisms xof xHumoral xImmunity 52
Chapter x14 xSpecialized xImmunity xat xEpithelial xBarriers xand xin xImmune xPrivileged xTissues 56
Chapter x15 xImmunologic xTolerance xand xAutoimmunity 62
Chapter x16 xImmunity xto xMicrobes 67
Chapter x17 xTransplantation xImmunology 72
Chapter x18 xTumor xImmunology 77
Chapter x19 xHypersensitivity xDisorders 81
Chapter x20 xAllergy 86
Chapter x21 xPrimary xand xAcquired xImmunodeficiencies 89
,Chapter 01: Properties and Overview of Immune Responses
x x x x x x x
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
x x x x x x x x x
MULTIPLE xCHOICE
1. The xprincipal xfunction xof xthe ximmune xsystem xis:
a. Defense xagainst xcancer
b. Repair xof xinjured xtissues
c. Defense xagainst xmicrobial xinfections
d. Prevention xof xinflammatory xdiseases
e. Protection xagainst xenvironmental xtoxins
ANS: x x C
The ximmune xsystem xhas xevolved xin xthe xsetting xof xselective xpressures ximposed xby xmicrobial
xinfections. xAlthough ximmune xresponses xto xcancer xmay xoccur, xthe xconcept xthat
x“immunosurveillance” xagainst xcancer xis xa xprincipal xfunction xof xthe ximmune xsystem xis
xcontroversial. xRepair xof xinjured xtissues xmay xbe xa xsecondary xconsequence xof xthe ximmune
xresponses xand xinflammation. xAlthough xthe ximmune xsystem xhas xregulatory xfeatures xthat xare
xneeded xto xprevent xexcessive xinflammation, xprevention xof xinflammatory xdiseases xis xnot xa
xprimary xfunction. xThe ximmune xsystem xcan xprotect xagainst xmicrobial xtoxins, xbut xit xgenerally
xdoes xnot xoffer xprotection xagainst xtoxins xof xnonbiologic xorigin.
2. Which xof xthe xfollowing xinfectious xdiseases xwas xprevented xby xthe xfirst
xsuccessful xvaccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: x x C
In x1798, xEdward xJenner xreported xthe xfirst xintentional xsuccessful xvaccination, xwhich xwas
xagainst xsmallpox xin xa xboy, xusing xmaterial xfrom xthe xcowpox xpustules xof xa xmilkmaid. xIn
x1980, xsmallpox xwas xreported xto xbe xeradicated xworldwide xby xa xvaccination xprogram.
xEffective xvaccines xagainst xtetanus xtoxin, xrubella xvirus, xand xpoliovirus xwere xdeveloped xin
xthe x20th xcentury xand xare xwidely xused. xThere xis xno xeffective xvaccine xagainst
xMycobacterium xtuberculosis.
3. Which xof xthe xfollowing xis xa xunique xproperty xof xthe xadaptive ximmune xsystem?
a. Highly xdiverse xrepertoire xof xspecificities xfor xantigens
b. Self-nonself xdiscrimination
c. Recognition xof xmicrobial xstructures xby xboth xcell-associated xand xsoluble xreceptors
d. Protection xagainst xviral xinfections
e. Responses xthat xhave xthe xsame xkinetics xand xmagnitude xon xrepeated xexposure xto
xthe xsame xmicrobe
ANS: x x A
, Highly xdiverse xrepertoires xof xspecificities xfor xantigens xare xfound xonly xin xT xand xB
xlymphocytes, xwhich xare xthe xcentral xcellular xcomponents xof xthe xadaptive ximmune xsystem.
xBoth xthe xinnate xand xthe xadaptive ximmune xsystems xuse xcell-associated xand xsoluble
xreceptors xto xrecognize xmicrobes, xdisplay xsome xdegree xof xself-nonself xdiscrimination, xand
xprotect xagainst xviruses. xOn xrepeated xexposure xto xthe xsame xmicrobe, xthe xadaptive ximmune
xresponse xbecomes xmore xrapid xand xof xgreater xmagnitude; xthis xis xthe xmanifestation xof
xmemory.
4. Antibodies xand xT xlymphocytes xare xthe xrespective xmediators xof xwhich xtwo xtypes
xof ximmunity?
a. Innate xand xadaptive
b. Passive xand xactive
c. Specific xand xnonspecific
d. Humoral xand xcell-mediated
e. Adult xand xneonatal
ANS: x x D
Both xB xand xT xlymphocytes xare xprincipal xcomponents xof xadaptive ximmunity. xB
xlymphocytes xproduce xantibodies, xwhich xare xthe xrecognition xand xeffector xmolecules xof
xhumoral ximmune xresponses xto xextracellular xpathogens. xT xcells xrecognize xand xpromote
xeradication xof xintracellular xpathogens xin xcell-mediated ximmunity. xPassive xand xactive
ximmunity xboth xcan xbe xmediated xby xeither xB xor xT xlymphocytes. xSpecific ximmunity xis
xanother xterm xfor xadaptive ximmunity. xBoth xB xand xT xlymphocytes xparticipate xin xadult
xadaptive ximmunity xbut xare xstill xdeveloping xin xthe xneonatal xperiod.
5. The xtwo xmajor xfunctional xclasses xof xeffector xT xlymphocytes xare:
a. Helper xT xlymphocytes xand xcytotoxic xT xlymphocytes
b. Natural xkiller xcells xand xcytoWtoWxW
ic.TTlBSM
ymph.oW
cyStes
c. Memory xT xcells xand xeffector xT xcells
d. Helper xcells xand xantigen-presenting xcells
e. Cytotoxic xT xlymphocytes xand xtarget xcells
ANS: x x A
T xcells xcan xbe xclassified xinto xeffector xsubsets xthat xperform xdifferent xeffector xfunctions.
xMost xeffector xT xcells xare xeither xhelper xT xlymphocytes, xwhich xenhance xthe xresponses xof
xother ximmune xcells, xincluding xphagocytes xand xB xcells, xto xinfections, xor xcytotoxic xT
xlymphocytes, xwhich xdirectly xkill xinfected xcells. xNatural xkiller xcells xare xnot xT
xlymphocytes.
Antigen-presenting xcells xusually xare xnot xT xcells. xMemory xT xcells xare xnot xeffector xT xcells.
6. Which xof xthe xfollowing xcell xtypes xis xrequired xfor xall xadaptive xhumoral ximmune xresponses?
a. Natural xkiller xcells
b. Dendritic xcells
c. Cytolytic xT xlymphocytes
d. B xlymphocytes
e. Helper xT xlymphocytes
ANS: x x D
Humoral ximmune xresponses xare xantibody-mediated ximmune xresponses, xand xall xantibodies
xare xmade xby xB xlymphocytes xand xno xother xcell xtype.
