, Rubin's Pathology: Clinicopathologic Foundations of Medicine Testb
mi mi mi mi mi mi
ank/Studyguide
Chapter 1: Cell Adaptation, Injury and Death
mi mi mi mi mi mi
Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a resu
mi mi mi mi mi mi mi mi mi mi mi mi mi
1. lt of:
mi
A) release of stored calcium from the mitochondria.
mi mi mi mi mi mi
B) improved intracellular volume regulation.mi mi mi
C) decreased influx across the cell membrane.mi mi mi mi mi
D) attraction of calcium to fatty infiltrates.
mi mi mi mi mi
The patient is found to have liver disease, resulting in the removal of a lobe of his liver.
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
2. Adaptation to the reduced size of the liver leads to
mi mi mi mi mi mi mi mi mi mi
of the remaining liver cells mi mi mi mi
.
A) metaplasia
B) organ atrophy mi
C) compensatory hyperplasia mi
D) physiologic hypertrophy mi
A person eating peanuts starts choking and collapses. His airway obstruction is partial
mi mi mi mi mi mi mi mi mi mi mi mi
ly cleared, but he remains hypoxic until he reaches the hospital. The prolonged cell hy
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
3. poxia caused a cerebral infarction and resulting
mi mi in the brain.
mi mi mi mi mi mi mi
A) caspase activation mi
B) coagulation necrosis mi
C) rapid phagocytosis mi
D) protein p53 deficiency mi mi
Bacteria and viruses cause cell damage by
mi mi mi mi mi mi mi
4. , which is unique from the intracellula
mi mi mi mi mi mi
r damage caused by other injurious agents.
mi mi mi mi mi mi
A) disrupting the sodium/potassium ATPase pump mi mi mi mi
B) interrupting oxidative metabolism processes mi mi mi
C) replicating and producing continued injury mi mi mi mi
D) decreasing protein synthesis and function mi mi mi mi
The patient has a prolonged interruption in arterial blood flow to his left kidney, causing hy
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
5. poxic cell injury and the release of free radicals. Free radicals damage cells by:
mi mi mi mi mi mi mi mi mi mi mi mi mi
A) destroying phospholipids in the cell membrane.mi mi mi mi mi
B) altering the immune response of the cell.
mi mi mi mi mi mi
,C) disrupting calcium storage in the cell.
mi mi mi mi mi
D) inactivation of enzymes and mitochondria. mi mi mi mi
6. Injured cells have impaired flow of substances through the cell membrane as a result of:
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
A) increased fat load. mi mi
B) altered permeability.
mi
C) altered glucose utilization.
mi mi
D) increased surface receptors. mi mi
7. Reversible adaptive intracellular responses are initiated by:
mi mi mi mi mi mi
A) stimulus overload. mi
B) genetic mutations. mi
C) chemical messengers. mi
D) mitochondrial DNA. mi
8. Injured cells become very swollen as a result of:
mi mi mi mi mi mi mi mi
A) increased cell protein synthesis.
mi mi mi
B) altered cell volume regulation.
mi mi mi
C) passive entry of potassium into the cell.
mi mi mi mi mi mi
D) bleb formation in the plasma membrane.
mi mi mi mi mi
A diabetic patient has impaired sensation, circulation, and oxygenation of his feet. He steps
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
on a piece of glass, the wound does not heal, and the area tissue becomes necrotic. The ne
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
9. crotic cell death is characterized by:
mi mi mi mi mi
A) rapid apoptosis.
mi
B) cellular rupture. mi
C) shrinkage and collapse. mi mi
D) chronic inflammation. mi
A 99-year-
mi
10. old woman has experienced the decline of cell function associated with age. A group of th
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
eories of cellular aging focus on programmed:
mi mi mi mi mi mi
A) changes with genetic influences. mi mi mi
B) elimination of cell receptor sites. mi mi mi mi
C) insufficient telomerase enzyme. mi mi
D) DNA mutation or faulty repair.
mi mi mi mi
An 89-year-
mi
old female patient has experienced significant decreases in her mobility and stamina durin
mi mi mi mi mi mi mi mi mi mi mi mi
g a 3-
mi mi
11. week hospital stay for the treatment of a femoral head fracture. Which of the following ph
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
, enomena most likely accounts for the patients decrease in muscle function
mi mi mi mi mi mi mi mi mi mi
that underlies her reduced mobility?
mi mi mi mi
A) Impaired muscle cell metabolism resulting from metaplasia
mi mi mi mi mi mi
B) Dysplasia as a consequence of inflammation during bone remodeling
mi mi mi mi mi mi mi mi
C) Disuse atrophy of muscle cells during a prolonged period of immobility
mi mi mi mi mi mi mi mi mi mi
D) Ischemic atrophy resulting from vascular changes while on bedrest
mi mi mi mi mi mi mi mi
A 20-year-
mi
old college student has presented to her campus medical clinic for a scheduled Papanicolao
mi mi mi mi mi mi mi mi mi mi mi mi mi
12. u (Pap) smear. The clinician who will interpret the smear will examine cell samples for ev
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
idence of: mi
A) changes in cell shape, size, and organization.
mi mi mi mi mi mi
B) the presence of unexpected cell types.
mi mi mi mi mi
C) ischemic changes in cell samples. mi mi mi mi
D) abnormally high numbers of cells in a specified field. mi mi mi mi mi mi mi mi
Which of the following pathophysiologic processes is most likely to result in metastatic calci
mi mi mi mi mi mi mi mi mi mi mi mi mi
13. cation?
A) Benign prostatic hyperplasia mi mi
B) Liver cirrhosis mi
C) Impaired glycogen metabolism mi mi
D) Hyperparathyroidism
Despite the low levels of radiation used in contemporary radiologic imaging, a radiology te
mi mi mi mi mi mi mi mi mi mi mi mi mi
nician is aware of the need to minimize her exposure to ionizing radiation. What is the prim
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
14. y rationale for the technicians precautions?
mi mi mi mi mi
A) Radiation stimulates pathologic cell hypertrophy and hyperplasia.
mi mi mi mi mi mi
B) Radiation results in the accumulation of endogenous waste products in the cytoplasm.
mi mi mi mi mi mi mi mi mi mi mi
C) Radiation interferes with DNA synthesis and mitosis.
mi mi mi mi mi mi
D) Radiation decreases the action potential of rapidly dividing cells.
mi mi mi mi mi mi mi mi
The parents of a 4-year-
mi mi mi mi
old girl have sought care because their daughter has admitted to chewing and swallowing i
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
15. mported toy figurines that have been determined to be made of lead. Which of the followin
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
g blood tests should the care team prioritize?
mi mi mi mi mi mi mi
A) White blood cell levels with differential
mi mi mi mi mi
B) Red blood cell levels and morphology
mi mi mi mi mi
C) Urea and creatinine levels
mi mi mi
D) Liver function panel mi mi
mi mi mi mi mi mi
ank/Studyguide
Chapter 1: Cell Adaptation, Injury and Death
mi mi mi mi mi mi
Ischemia and other toxic injuries increase the accumulation of intracellular calcium as a resu
mi mi mi mi mi mi mi mi mi mi mi mi mi
1. lt of:
mi
A) release of stored calcium from the mitochondria.
mi mi mi mi mi mi
B) improved intracellular volume regulation.mi mi mi
C) decreased influx across the cell membrane.mi mi mi mi mi
D) attraction of calcium to fatty infiltrates.
mi mi mi mi mi
The patient is found to have liver disease, resulting in the removal of a lobe of his liver.
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
2. Adaptation to the reduced size of the liver leads to
mi mi mi mi mi mi mi mi mi mi
of the remaining liver cells mi mi mi mi
.
A) metaplasia
B) organ atrophy mi
C) compensatory hyperplasia mi
D) physiologic hypertrophy mi
A person eating peanuts starts choking and collapses. His airway obstruction is partial
mi mi mi mi mi mi mi mi mi mi mi mi
ly cleared, but he remains hypoxic until he reaches the hospital. The prolonged cell hy
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
3. poxia caused a cerebral infarction and resulting
mi mi in the brain.
mi mi mi mi mi mi mi
A) caspase activation mi
B) coagulation necrosis mi
C) rapid phagocytosis mi
D) protein p53 deficiency mi mi
Bacteria and viruses cause cell damage by
mi mi mi mi mi mi mi
4. , which is unique from the intracellula
mi mi mi mi mi mi
r damage caused by other injurious agents.
mi mi mi mi mi mi
A) disrupting the sodium/potassium ATPase pump mi mi mi mi
B) interrupting oxidative metabolism processes mi mi mi
C) replicating and producing continued injury mi mi mi mi
D) decreasing protein synthesis and function mi mi mi mi
The patient has a prolonged interruption in arterial blood flow to his left kidney, causing hy
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
5. poxic cell injury and the release of free radicals. Free radicals damage cells by:
mi mi mi mi mi mi mi mi mi mi mi mi mi
A) destroying phospholipids in the cell membrane.mi mi mi mi mi
B) altering the immune response of the cell.
mi mi mi mi mi mi
,C) disrupting calcium storage in the cell.
mi mi mi mi mi
D) inactivation of enzymes and mitochondria. mi mi mi mi
6. Injured cells have impaired flow of substances through the cell membrane as a result of:
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
A) increased fat load. mi mi
B) altered permeability.
mi
C) altered glucose utilization.
mi mi
D) increased surface receptors. mi mi
7. Reversible adaptive intracellular responses are initiated by:
mi mi mi mi mi mi
A) stimulus overload. mi
B) genetic mutations. mi
C) chemical messengers. mi
D) mitochondrial DNA. mi
8. Injured cells become very swollen as a result of:
mi mi mi mi mi mi mi mi
A) increased cell protein synthesis.
mi mi mi
B) altered cell volume regulation.
mi mi mi
C) passive entry of potassium into the cell.
mi mi mi mi mi mi
D) bleb formation in the plasma membrane.
mi mi mi mi mi
A diabetic patient has impaired sensation, circulation, and oxygenation of his feet. He steps
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
on a piece of glass, the wound does not heal, and the area tissue becomes necrotic. The ne
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
9. crotic cell death is characterized by:
mi mi mi mi mi
A) rapid apoptosis.
mi
B) cellular rupture. mi
C) shrinkage and collapse. mi mi
D) chronic inflammation. mi
A 99-year-
mi
10. old woman has experienced the decline of cell function associated with age. A group of th
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
eories of cellular aging focus on programmed:
mi mi mi mi mi mi
A) changes with genetic influences. mi mi mi
B) elimination of cell receptor sites. mi mi mi mi
C) insufficient telomerase enzyme. mi mi
D) DNA mutation or faulty repair.
mi mi mi mi
An 89-year-
mi
old female patient has experienced significant decreases in her mobility and stamina durin
mi mi mi mi mi mi mi mi mi mi mi mi
g a 3-
mi mi
11. week hospital stay for the treatment of a femoral head fracture. Which of the following ph
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
, enomena most likely accounts for the patients decrease in muscle function
mi mi mi mi mi mi mi mi mi mi
that underlies her reduced mobility?
mi mi mi mi
A) Impaired muscle cell metabolism resulting from metaplasia
mi mi mi mi mi mi
B) Dysplasia as a consequence of inflammation during bone remodeling
mi mi mi mi mi mi mi mi
C) Disuse atrophy of muscle cells during a prolonged period of immobility
mi mi mi mi mi mi mi mi mi mi
D) Ischemic atrophy resulting from vascular changes while on bedrest
mi mi mi mi mi mi mi mi
A 20-year-
mi
old college student has presented to her campus medical clinic for a scheduled Papanicolao
mi mi mi mi mi mi mi mi mi mi mi mi mi
12. u (Pap) smear. The clinician who will interpret the smear will examine cell samples for ev
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
idence of: mi
A) changes in cell shape, size, and organization.
mi mi mi mi mi mi
B) the presence of unexpected cell types.
mi mi mi mi mi
C) ischemic changes in cell samples. mi mi mi mi
D) abnormally high numbers of cells in a specified field. mi mi mi mi mi mi mi mi
Which of the following pathophysiologic processes is most likely to result in metastatic calci
mi mi mi mi mi mi mi mi mi mi mi mi mi
13. cation?
A) Benign prostatic hyperplasia mi mi
B) Liver cirrhosis mi
C) Impaired glycogen metabolism mi mi
D) Hyperparathyroidism
Despite the low levels of radiation used in contemporary radiologic imaging, a radiology te
mi mi mi mi mi mi mi mi mi mi mi mi mi
nician is aware of the need to minimize her exposure to ionizing radiation. What is the prim
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
14. y rationale for the technicians precautions?
mi mi mi mi mi
A) Radiation stimulates pathologic cell hypertrophy and hyperplasia.
mi mi mi mi mi mi
B) Radiation results in the accumulation of endogenous waste products in the cytoplasm.
mi mi mi mi mi mi mi mi mi mi mi
C) Radiation interferes with DNA synthesis and mitosis.
mi mi mi mi mi mi
D) Radiation decreases the action potential of rapidly dividing cells.
mi mi mi mi mi mi mi mi
The parents of a 4-year-
mi mi mi mi
old girl have sought care because their daughter has admitted to chewing and swallowing i
mi mi mi mi mi mi mi mi mi mi mi mi mi mi
15. mported toy figurines that have been determined to be made of lead. Which of the followin
mi mi mi mi mi mi mi mi mi mi mi mi mi mi mi
g blood tests should the care team prioritize?
mi mi mi mi mi mi mi
A) White blood cell levels with differential
mi mi mi mi mi
B) Red blood cell levels and morphology
mi mi mi mi mi
C) Urea and creatinine levels
mi mi mi
D) Liver function panel mi mi
