1
NBME 28
NBME 28 TEST 2 QUESTIONS & ANSWERS |GRADE
A|100% CORRECT (VERIFIED SOLUTION)
(2025/2026 UPDATE)
1. B. 1. 32: In a patient taking Infliximab what should you watch
out for?: You should watch out for relapse of Tuberculosis
This is because it inhibits TNF-Alpha which is a cytokine secreted by
macrophages and this will support granuloma formation
Need Granulomas in order to control TB
2. B. 1. 34: How Does Exercise Indued Asthma present?: This will
present as dyspnea, cough, and wheezing that begins during or
shortly after exercise
Usually treated with a SABA or alternative of Montelukast
3. B. 1. 35: What does Protein C inhibit in the Coagulation
Cascade?: This will inhibit Factor V and Factor VIII respectively
NBME 28
, 2
NBME 28
4. B. 1. 36: When trying to match Correct HLA subtypes what will
recipient T lymphocytes react to in donor HLA Types?: They
will react too the HLA type that is absent in the recipient
5. B. 1. 40: What is Lentigo Maligna?: This is a precancerous
lesions of Intraepithelial proliferation of Dysplastic melanocytes
Usually occurs in the elderly on their face.
Look for darkly pigmented maculae, with irregular borders and careful
cause it can transform into Melanoma
6. B. 1. 43: Most common location for a Diverticula?: Sigmoid
colon
7. B. 1. 47: What can be send with aspirin and is a drug that
inhibits platelets interaction with Fibrinogen: Abciximab which
is a monoclonal Antibody that inhibits Glycoproteins IIB/IIIA on the
platelet surface.
Normally Glycoproteins IIB/IIIA normally binds with fibrinogen and
results in platelet aggregration and thrombus formation
NBME 28
, 3
NBME 28
8. B. 1. 48: How to Hepatocytes and renal tubular epithelial cells
regenerate?: They get stimulated from G0 phase and will renter
the cell cycle
9. B. 1. 49: What is a characteristic of Atrial Septal defect on
Heart sounds?: Will get WIDELY split S2 due to increased blood
flow through the pulmonic valve.
IF severe enough you can get pulmonary hypertension and
development of Eisenmenger syndrome (Reversale of Left to right)
10. B. 1. 50: What is Somatic symptom disorder?: This is when a
patient gets preoccupied with 1 or more Somatic symptoms
disorders and they disrupt the patients daily life
They are unconsciously produced
Individuals with somatic symptom disorder often have multiple
physical symptoms that cause significant distress and also have a
history of extensive (and fruitless) diagnostic testing and medical
NBME 28
NBME 28
NBME 28 TEST 2 QUESTIONS & ANSWERS |GRADE
A|100% CORRECT (VERIFIED SOLUTION)
(2025/2026 UPDATE)
1. B. 1. 32: In a patient taking Infliximab what should you watch
out for?: You should watch out for relapse of Tuberculosis
This is because it inhibits TNF-Alpha which is a cytokine secreted by
macrophages and this will support granuloma formation
Need Granulomas in order to control TB
2. B. 1. 34: How Does Exercise Indued Asthma present?: This will
present as dyspnea, cough, and wheezing that begins during or
shortly after exercise
Usually treated with a SABA or alternative of Montelukast
3. B. 1. 35: What does Protein C inhibit in the Coagulation
Cascade?: This will inhibit Factor V and Factor VIII respectively
NBME 28
, 2
NBME 28
4. B. 1. 36: When trying to match Correct HLA subtypes what will
recipient T lymphocytes react to in donor HLA Types?: They
will react too the HLA type that is absent in the recipient
5. B. 1. 40: What is Lentigo Maligna?: This is a precancerous
lesions of Intraepithelial proliferation of Dysplastic melanocytes
Usually occurs in the elderly on their face.
Look for darkly pigmented maculae, with irregular borders and careful
cause it can transform into Melanoma
6. B. 1. 43: Most common location for a Diverticula?: Sigmoid
colon
7. B. 1. 47: What can be send with aspirin and is a drug that
inhibits platelets interaction with Fibrinogen: Abciximab which
is a monoclonal Antibody that inhibits Glycoproteins IIB/IIIA on the
platelet surface.
Normally Glycoproteins IIB/IIIA normally binds with fibrinogen and
results in platelet aggregration and thrombus formation
NBME 28
, 3
NBME 28
8. B. 1. 48: How to Hepatocytes and renal tubular epithelial cells
regenerate?: They get stimulated from G0 phase and will renter
the cell cycle
9. B. 1. 49: What is a characteristic of Atrial Septal defect on
Heart sounds?: Will get WIDELY split S2 due to increased blood
flow through the pulmonic valve.
IF severe enough you can get pulmonary hypertension and
development of Eisenmenger syndrome (Reversale of Left to right)
10. B. 1. 50: What is Somatic symptom disorder?: This is when a
patient gets preoccupied with 1 or more Somatic symptoms
disorders and they disrupt the patients daily life
They are unconsciously produced
Individuals with somatic symptom disorder often have multiple
physical symptoms that cause significant distress and also have a
history of extensive (and fruitless) diagnostic testing and medical
NBME 28
