CMN 548 Unit 5 Exam Questions and
Answers
Potency - Correct Answers -refers to the relative dose required to achieve certain
effects, not to the efficacy of a drug
Agonist (full agonist) - Correct Answers -A drug that binds to a specific receptor
producing an effect identical to that usually produced by the neurotransmitter affecting
that receptor
Pharmacodynamics - Correct Answers -The time course and intensity of a drug's
effect/what the drug does to the body
Pharmacokinetics - Correct Answers -What the body does to a drug
Tolerance - Correct Answers -Develops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased sensitivity to adverse
effects of a drug
What is the recommended monitoring for orthostatic hypotension when using IM LOW
potency DRAs? - Correct Answers -The clinician should measure the pts BP (lying +
standing) before and after the first dose and during the first few days of tx
When is the CBC indicated for a pt being treated with DRA? - Correct Answers -if a pt
reports a sore throat, fever, a CBC should be done immediately to check for serious
blood dyscrasia
What are the s/s of peripheral anticholinergic effects r/t LOW potency DRA use? -
Correct Answers -Peripheral anticholinergic effects:
-dry mouth and nose
-blurred vision
-constipation (severe constipation can progress to paralytic ileus)
-urinary retention
-mydriasis
-some may have N/V
-weight gain
Stevens-Johnson Syndrome - Correct Answers -A systemic, immune-mediated reaction
that can be fatal or result in permanent scarring or blindness
,Antagonist - Correct Answers -A compound that blinds to a receptor that blocks or
reduces the action of another substance at the receptor site
Hyponatremia - Correct Answers -Common symptoms of this medication side effect
include confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index - Correct Answers -ratio of the median toxic dose to the median
effective dose
Somnolence - Correct Answers -Daytime sleepiness
Black Box Warning - Correct Answers -This warning reflects that a medication may
cause a serious or even life-threatening side effect
Partial or Mixed Agonist - Correct Answers -A compound that elicits a partial
pharmacological response at the receptor site involved
Remission - Correct Answers -The degree of improvement to below the syndromal
threshold of a disorder
Paradoxical - Correct Answers -A response to a drug that represents the clinical effect
opposite of what is expected
Inverse agonist - Correct Answers -An agent that binds to the same receptor site as an
agonist but produces the opposite pharmacological effect
4 major transmitters - Correct Answers -Dopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - Correct Answers -affects mood, Psychosis, ADHD,
Addiction
Serotonin transmitter affects? - Correct Answers -Depression, aggression, OCD, Panic,
GAD, Social Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - Correct Answers -Affects mood, anxiety, psychosis, ADHD
(part), drug withdrawal
GABA affects? - Correct Answers -Fear, anxiety, worry
Irreversible MAOIs Types - Correct Answers -MAOa and MAOb
Irreversible MAOIs medications - Correct Answers -Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
, A single dose of MAOIs may persist in its inhibition of MAO for how long? - Correct
Answers -because they irreversibly inactivate MAOs, the therapeutic effect of a single
dose of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - Correct Answers -orthostatic
hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - Correct Answers -Moclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? - Correct
Answers -MAO activity recovers completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - Correct Answers -depression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - Correct Answers -Avoid caffeine
intake of 2L of fluid/day
addition of dietary salt
adjust HTN meds
support stocking
severe cases *tx with fludrocortisone (Florinef) a mineralcorticoid
How long should the NP wait to begin another tx for depression when stopping an MAOI
to begin another MAOI or SSRI? - Correct Answers -irreversible MAOI-wait 14 days
MAO activity recovers completely 24-48 hrs after last dose of RIMA
How long should the NP wait to begin an MAOI after d/c a pt from fluoxetine (Prozac)? -
Correct Answers -when switching from an antidepressant to an irreversible MAOI-
should wait 10-14 days (or 5 weeks for fluoxetine (Prozac) before starting use of MAOI
to avoid drug interactions
Complications for using MAOIs for pts who have bipolar I and schizophrenia? - Correct
Answers -induction of mania in the depressed phase of bipolar I disorder and triggering
of a psychotic decompensation in persons with schizophrenia
Symptoms of tyramine-induced hypertensive crisis? - Correct Answers -Severe HTN
HA
Answers
Potency - Correct Answers -refers to the relative dose required to achieve certain
effects, not to the efficacy of a drug
Agonist (full agonist) - Correct Answers -A drug that binds to a specific receptor
producing an effect identical to that usually produced by the neurotransmitter affecting
that receptor
Pharmacodynamics - Correct Answers -The time course and intensity of a drug's
effect/what the drug does to the body
Pharmacokinetics - Correct Answers -What the body does to a drug
Tolerance - Correct Answers -Develops over time a need to use increased doses of a
medication/drug to maintain a clinical effect. Or, a decreased sensitivity to adverse
effects of a drug
What is the recommended monitoring for orthostatic hypotension when using IM LOW
potency DRAs? - Correct Answers -The clinician should measure the pts BP (lying +
standing) before and after the first dose and during the first few days of tx
When is the CBC indicated for a pt being treated with DRA? - Correct Answers -if a pt
reports a sore throat, fever, a CBC should be done immediately to check for serious
blood dyscrasia
What are the s/s of peripheral anticholinergic effects r/t LOW potency DRA use? -
Correct Answers -Peripheral anticholinergic effects:
-dry mouth and nose
-blurred vision
-constipation (severe constipation can progress to paralytic ileus)
-urinary retention
-mydriasis
-some may have N/V
-weight gain
Stevens-Johnson Syndrome - Correct Answers -A systemic, immune-mediated reaction
that can be fatal or result in permanent scarring or blindness
,Antagonist - Correct Answers -A compound that blinds to a receptor that blocks or
reduces the action of another substance at the receptor site
Hyponatremia - Correct Answers -Common symptoms of this medication side effect
include confusion, agitation, and lethargy. (tx with oxcarbazepine & SSRIs)
Therapeutic index - Correct Answers -ratio of the median toxic dose to the median
effective dose
Somnolence - Correct Answers -Daytime sleepiness
Black Box Warning - Correct Answers -This warning reflects that a medication may
cause a serious or even life-threatening side effect
Partial or Mixed Agonist - Correct Answers -A compound that elicits a partial
pharmacological response at the receptor site involved
Remission - Correct Answers -The degree of improvement to below the syndromal
threshold of a disorder
Paradoxical - Correct Answers -A response to a drug that represents the clinical effect
opposite of what is expected
Inverse agonist - Correct Answers -An agent that binds to the same receptor site as an
agonist but produces the opposite pharmacological effect
4 major transmitters - Correct Answers -Dopamine, Serotonin, GABA, Norepinephrine
Dopamine transmitter affects? - Correct Answers -affects mood, Psychosis, ADHD,
Addiction
Serotonin transmitter affects? - Correct Answers -Depression, aggression, OCD, Panic,
GAD, Social Anxiety, PTSD, Violence, Sexual dysfunction, substance addiction
Norepinephrine affects? - Correct Answers -Affects mood, anxiety, psychosis, ADHD
(part), drug withdrawal
GABA affects? - Correct Answers -Fear, anxiety, worry
Irreversible MAOIs Types - Correct Answers -MAOa and MAOb
Irreversible MAOIs medications - Correct Answers -Phenelzine (Nardil)
isocarboxazid (Marplan)
tranylcypromine (Parnate)
, A single dose of MAOIs may persist in its inhibition of MAO for how long? - Correct
Answers -because they irreversibly inactivate MAOs, the therapeutic effect of a single
dose of irreversible MAOIs may persist for as long as 2 weeks
What are the most frequent adverse effects of MAOIs? - Correct Answers -orthostatic
hypotension, insomnia, weight gain, edema, sexual dysfunction
Reversible MAOIs (RIMAs) medications? - Correct Answers -Moclobemide (Maerix)
How long will it take to recover MAO activity after a final dose of RIMA? - Correct
Answers -MAO activity recovers completely 24-48 hrs after the last dose of a RIMA
MAOIs are used to treat what conditions? - Correct Answers -depression
panic disorder
social phobia
bulimia nervosa
ptsd
anginal pain
atypical facial pain
migraine
adhd
idiopathic orthostatic hypotension
Depression associated with TBI
Treatment for MAOI induced orthostatic hypotension? - Correct Answers -Avoid caffeine
intake of 2L of fluid/day
addition of dietary salt
adjust HTN meds
support stocking
severe cases *tx with fludrocortisone (Florinef) a mineralcorticoid
How long should the NP wait to begin another tx for depression when stopping an MAOI
to begin another MAOI or SSRI? - Correct Answers -irreversible MAOI-wait 14 days
MAO activity recovers completely 24-48 hrs after last dose of RIMA
How long should the NP wait to begin an MAOI after d/c a pt from fluoxetine (Prozac)? -
Correct Answers -when switching from an antidepressant to an irreversible MAOI-
should wait 10-14 days (or 5 weeks for fluoxetine (Prozac) before starting use of MAOI
to avoid drug interactions
Complications for using MAOIs for pts who have bipolar I and schizophrenia? - Correct
Answers -induction of mania in the depressed phase of bipolar I disorder and triggering
of a psychotic decompensation in persons with schizophrenia
Symptoms of tyramine-induced hypertensive crisis? - Correct Answers -Severe HTN
HA
