Answers 100% Approved
What is differentiation in cancer cells? Refers to the extent that cancer/neoplastic cells
resemble normal cells both structurally and functionally
What is it called when total cellular disorganization, abnormal cell appearance, and cell
dysfunction occurs? Anaplasia
*An undifferentiated cells that is more unpredictable
Which cells are less likely to reproduce - undifferentiated or differentiated? Differentiated
Cancer Cell Characteristics Contact inhibition not present - ex: skin cells begin invading
muscle cells
Communication not present
,Proliferation control not present - sometimes immortal cells die unpredictably
Unpredictable proliferation rate
"Self" HLA antigens may be mustered making it harder to mark a virus and kill it later
Benign Tumors Well-differentiated
Remain localized
Well-demarcated
Cohesive
Not invasive
Do not travel to other areas
Progressive and slow
*Can be clustered and easily removed
Malignant Tumors Poorly differentiated
, Invasive
Lack adhesion to tumor mass
Travel to other areas - metastasis
Erratic and rapid/slow
*Can form more tumors making it harder to fully remove
How do malignant cells travel? Blood stream and lymphatic system
Grade I TNM System Indicates that the cells are well-differentiated
Grade II TNM System Indicates cells are moderately differentiated
Grade III TNM System Indicates poorly differentiated or anaplastic cells
How does the TNM System classify tumors? T - tumor size (ex: T2 = 2 cm or T4 = 4 cm)