NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM -
FINAL EXAM QUESTIONS AND CORRECT ANSWERS LATEST 2025-2026
Question 1
Kasey fractured his ankle in two places and is asking for medication for his pain. The appropriate
first-line medication would be:
- Acetaminophen with hydrocodone (Vicodin)
Question 2
Jack, age 8, has attention deficit disorder (ADD) and is prescribed methylphenidate (Ritalin). He
and his parents should be educated about the side effects of methylphenidate, which are:
- Insomnia and decreased appetite
Question 3
Monitoring for a child on methylphenidate for attention deficit hyperactivity disorder (ADHD)
includes:
- ADHD symptoms
- Routine height and weight checks
- Amount of methylphenidate being used
Question 4
When prescribing Adderall (amphetamine and dextroamphetamine) to adults with ADHD the
nurse practitioner will need to monitor:
- Blood pressure
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM / FINAL EXAM
,Question 5
Common mistakes practitioners make in treating anxiety disorders include:
- Thinking a partial response to medication is acceptable
Question 6
An appropriate first-line drug to try for mild to moderate generalized anxiety disorder would be:
- Buspirone (Buspar)
Question 7
An appropriate drug to initially treat panic disorder is:
- Diazepam (Valium)
Question 8
Prior to starting antidepressants, patients should have laboratory testing to rule out:
- Hypothyroidism
Question 9
David is a 34-year-old patient who is starting on paroxetine (Paxil) for depression. David's
education regarding his medication would include:
- He may experience sexual dysfunction beginning a month after he starts therapy.
Question 10
Jamison has been prescribed citalopram (Celexa) to treat his depression. Education regarding
how quickly selective serotonin reuptake inhibitor (SSRI) antidepressants work would be:
- Appetite and concentration improve in the first 1 to 2 weeks.
Question 11
The racial difference in drug pharmacokinetics seen in American Indian or Alaskan Natives are:
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM / FINAL EXAM
,- Largely unknown due to lack of studies of this population
Question 12
Pharmacokinetics among Asians are universal to all the Asian ethnic groups.
A. True
B. False
Question 13
Alterations in drug metabolism among Asians may lead to:
- Slower metabolism of antidepressants, requiring lower doses
Question 14
Asians from Eastern Asia are known to be fast acetylators. Fast acetylators:
- Require higher doses of drugs metabolized by acetylization to achieve efficacy
Question 15
Hispanic native healers (curanderas):
A. Are not heavily utilized by Hispanics who immigrate to the United States
B. Use herbs and teas in their treatment of illness
C. Provide unsafe advice to Hispanics and should not be trusted
D. Need to be licensed in their home country in order to practice in the United States
Question 16
Genetic polymorphisms account for differences in metabolism, including:
- Poor metabolizers, who lack a working enzyme
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM / FINAL EXAM
, - Intermediate metabolizers, who have one working, wild-type allele and one mutant allele
- Extensive metabolizers, with two normally functioning alleles
Question 17
Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:
- Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin
reuptake inhibitors
Question 18
Drugs that use CYP 3A4 isoenzymes for metabolism may:
- Induce the metabolism of another drug
- Inhibit the metabolism of another drug
Question 19
Rifampin is a nonspecific CYP450 inducer that may:
- Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure
Question 20
Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
- Increased levels of a co-administered drug, such as digoxin, that requires P- glycoprotein for
absorption and elimination
Question 21
Warfarin resistance may be seen in patients with VCORC1 mutation, leading to:
- Decreased response to warfarin
Question 22
Genetic testing for VCORC1 mutation to assess potential warfarin resistance is required prior to
prescribing warfarin.
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM / FINAL EXAM
FINAL EXAM QUESTIONS AND CORRECT ANSWERS LATEST 2025-2026
Question 1
Kasey fractured his ankle in two places and is asking for medication for his pain. The appropriate
first-line medication would be:
- Acetaminophen with hydrocodone (Vicodin)
Question 2
Jack, age 8, has attention deficit disorder (ADD) and is prescribed methylphenidate (Ritalin). He
and his parents should be educated about the side effects of methylphenidate, which are:
- Insomnia and decreased appetite
Question 3
Monitoring for a child on methylphenidate for attention deficit hyperactivity disorder (ADHD)
includes:
- ADHD symptoms
- Routine height and weight checks
- Amount of methylphenidate being used
Question 4
When prescribing Adderall (amphetamine and dextroamphetamine) to adults with ADHD the
nurse practitioner will need to monitor:
- Blood pressure
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM / FINAL EXAM
,Question 5
Common mistakes practitioners make in treating anxiety disorders include:
- Thinking a partial response to medication is acceptable
Question 6
An appropriate first-line drug to try for mild to moderate generalized anxiety disorder would be:
- Buspirone (Buspar)
Question 7
An appropriate drug to initially treat panic disorder is:
- Diazepam (Valium)
Question 8
Prior to starting antidepressants, patients should have laboratory testing to rule out:
- Hypothyroidism
Question 9
David is a 34-year-old patient who is starting on paroxetine (Paxil) for depression. David's
education regarding his medication would include:
- He may experience sexual dysfunction beginning a month after he starts therapy.
Question 10
Jamison has been prescribed citalopram (Celexa) to treat his depression. Education regarding
how quickly selective serotonin reuptake inhibitor (SSRI) antidepressants work would be:
- Appetite and concentration improve in the first 1 to 2 weeks.
Question 11
The racial difference in drug pharmacokinetics seen in American Indian or Alaskan Natives are:
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM / FINAL EXAM
,- Largely unknown due to lack of studies of this population
Question 12
Pharmacokinetics among Asians are universal to all the Asian ethnic groups.
A. True
B. False
Question 13
Alterations in drug metabolism among Asians may lead to:
- Slower metabolism of antidepressants, requiring lower doses
Question 14
Asians from Eastern Asia are known to be fast acetylators. Fast acetylators:
- Require higher doses of drugs metabolized by acetylization to achieve efficacy
Question 15
Hispanic native healers (curanderas):
A. Are not heavily utilized by Hispanics who immigrate to the United States
B. Use herbs and teas in their treatment of illness
C. Provide unsafe advice to Hispanics and should not be trusted
D. Need to be licensed in their home country in order to practice in the United States
Question 16
Genetic polymorphisms account for differences in metabolism, including:
- Poor metabolizers, who lack a working enzyme
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM / FINAL EXAM
, - Intermediate metabolizers, who have one working, wild-type allele and one mutant allele
- Extensive metabolizers, with two normally functioning alleles
Question 17
Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:
- Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin
reuptake inhibitors
Question 18
Drugs that use CYP 3A4 isoenzymes for metabolism may:
- Induce the metabolism of another drug
- Inhibit the metabolism of another drug
Question 19
Rifampin is a nonspecific CYP450 inducer that may:
- Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure
Question 20
Inhibition of P-glycoprotein by a drug such as quinidine may lead to:
- Increased levels of a co-administered drug, such as digoxin, that requires P- glycoprotein for
absorption and elimination
Question 21
Warfarin resistance may be seen in patients with VCORC1 mutation, leading to:
- Decreased response to warfarin
Question 22
Genetic testing for VCORC1 mutation to assess potential warfarin resistance is required prior to
prescribing warfarin.
NR565 ADVANCED PHARMACOLOGY FUNDAMENTALS MIDTERM / FINAL EXAM
