1
NBME 25
NBME 25 EXAM QUESTIONS WITH CORRECT
VERIFIED SOLUTIONS 100% GUARANTEED
PASS (LATEST UPDATE)
1. Mutations inactivating vit d 24-hydroxylase gene would cause
what: decreased conversion of active fit d into its inactive
metabolite, resulting in hypercalcemia
2. Positive predictive value is calculated by the formula::
(TP)/(TP+FP)
varies directly with prevalence
3. Negative predictive value is calculated by the formula::
(TN)/(TN+FN)
varies inversely with prevalence
4. Hepatocytes have the following functions: - filter and detox
portal venous blood
- metabolize medications
NBME 25
,- synthesize coag factors (V, VII, IX, X, XI, XII, protein C/S),
complement, apoproteins, triglycerides, cholesterol, bile acids,
albumin
- gluconeogenesis
13. What can cause PT time to increase?: deficiency of factor VII
14. symptoms of chronic liver dysfunction?: - hypoglycemia from
impaired gluconeogenesis
- nausea from increased gut transit time
- jaundice from hyperbilirubinemia
- hypogonadism from altered metabolism of estrogens
-malnutrition/weight loss
15. damage to endothelial cells can cause: hypercoaguability and
associated vascular disease
endothelial cells line the inner lumen of blood vessels and function to
reduce clotting
16. fibroblast damage leads to: disordered synthesis of ECM
, 3
NBME 25
17. patient has a brain mass, smoked a lot for 50 years. lab
studies show polycythemia, hypercalcemia, microscopic
hematuria. immunostaining is positive for epithelial membrane
antigen and negative for carcinoembryonic antigen. what is
the most likely site of the primary neoplasm?: Kidney!
Renal cell carcinoma is an adenocarcinoma of tubular epithelial cells
(this is why it is + for epithelial membrane antigen!)
Super common in old male smokers. Presents with hematuria, flank
pain, weight loss, or fever.
Polycythemia/hypercalcemia as a result of paraneoplastic syndrome
production of EPO or PTHRP. Can also get hypercalcemia from bony
metastasis. 18. How do you diagnose RCC?: contrast enhanced
CT/MRI confirm with biopsy
biopsy shows polygonal clear cells because of accumulation of
lipid/carbohydrate content in the cells
NBME 25
NBME 25
NBME 25 EXAM QUESTIONS WITH CORRECT
VERIFIED SOLUTIONS 100% GUARANTEED
PASS (LATEST UPDATE)
1. Mutations inactivating vit d 24-hydroxylase gene would cause
what: decreased conversion of active fit d into its inactive
metabolite, resulting in hypercalcemia
2. Positive predictive value is calculated by the formula::
(TP)/(TP+FP)
varies directly with prevalence
3. Negative predictive value is calculated by the formula::
(TN)/(TN+FN)
varies inversely with prevalence
4. Hepatocytes have the following functions: - filter and detox
portal venous blood
- metabolize medications
NBME 25
,- synthesize coag factors (V, VII, IX, X, XI, XII, protein C/S),
complement, apoproteins, triglycerides, cholesterol, bile acids,
albumin
- gluconeogenesis
13. What can cause PT time to increase?: deficiency of factor VII
14. symptoms of chronic liver dysfunction?: - hypoglycemia from
impaired gluconeogenesis
- nausea from increased gut transit time
- jaundice from hyperbilirubinemia
- hypogonadism from altered metabolism of estrogens
-malnutrition/weight loss
15. damage to endothelial cells can cause: hypercoaguability and
associated vascular disease
endothelial cells line the inner lumen of blood vessels and function to
reduce clotting
16. fibroblast damage leads to: disordered synthesis of ECM
, 3
NBME 25
17. patient has a brain mass, smoked a lot for 50 years. lab
studies show polycythemia, hypercalcemia, microscopic
hematuria. immunostaining is positive for epithelial membrane
antigen and negative for carcinoembryonic antigen. what is
the most likely site of the primary neoplasm?: Kidney!
Renal cell carcinoma is an adenocarcinoma of tubular epithelial cells
(this is why it is + for epithelial membrane antigen!)
Super common in old male smokers. Presents with hematuria, flank
pain, weight loss, or fever.
Polycythemia/hypercalcemia as a result of paraneoplastic syndrome
production of EPO or PTHRP. Can also get hypercalcemia from bony
metastasis. 18. How do you diagnose RCC?: contrast enhanced
CT/MRI confirm with biopsy
biopsy shows polygonal clear cells because of accumulation of
lipid/carbohydrate content in the cells
NBME 25
