Biology
for Cambridge ®
IGCSE
2nd Edition
Gareth Williams
Richard Fosbery
Series Editor: Lawrie Ryan
, Library; p112: BIOLOGY MEDIA/Science Photo Library; p113: BIOPHOTO ASSOCI-
ATES/Science Photo Library; p118: ADAM HART-DAVIS/Science Photo Library;
3 p118: © satit_srihin/istock; p119: © gregepperson/istock; p122: © jo unruh/istock;
p123: © Nathan Benn/Ottochrome/Corbis; p123: © RGB Ventures/SuperStock/
Great Clarendon Street, Oxford, OX2 6DP, United Kingdom
Alamy; p123: © Eric Carr/Alamy; p124: Blend Images - Ariel Skelley; p124: © Rich-
Oxford University Press is a department of the University of Oxford. It
ard Levine/Demotix/Corbis; p125: Charmaine A Harvey; p125: © FAYYAZ AHMED/
furthers the University’s objective of excellence in research, scholarship,
epa/Corbis; p128: CNRI/Science Photo Library; p134: istock; p137: © PHOTOTAKE
and education by publishing worldwide. Oxford is a registered trade mark
Inc./Alamy; p138: MichaelTaylor/Shutterstock; p140: ANDREW SYRED/Science
of Oxford University Press in the UK and in certain other countries
Photo Library; p140: bikeriderlondon; p141: Peter Muller/CULTURA/Science Pho-
Text © Gareth Williams 2015
to Library; p147: Richard Fosberry; p147: Richard Fosberry; p150: AJ PHOTO/HOP
Alternative to practical paper and practice questions © OUP 2015 Original
AMERICAIN/Science Photo Library; p155: MEHAU KULYK/Science Photo Library;
illustrations © Gareth Williams and OUP 2015
p156: BIOPHOTO ASSOCIATES/Science Photo Library; p156: BIOPHOTO ASSOCI-
The right of Gareth Williams to be identified as author of this work has
ATES/Science Photo Library; p159: PROF S. CINTI/Science Photo Library; p160: ©
been asserted by him in accordance with the Copyright, Designs and
Michael Freema/Alamy; p161: Richard Fosberry; p164: © Photofusion Picture Li-
Patents Act 1988.
brary/Alamy; p167: ASTRID andamp;amp; HANNS-FRIEDER MICHLER/Science
First published in 2009
Photo Library; p168: © JohnPitcher/istock; p170: JEROME WEXLER/Science Photo
This edition published in 2015
Library; p171: NIGEL CATTLIN/Science Photo Library; p174: MAURO FERMARIEL-
All rights reserved. No part of this publication may be reproduced, stored LO/Science Photo Library; p175: © Eric Audras/Onoky/Corbis; p175: JOHN DUR-
in a retrieval system, or transmitted, in any form or by any means, HAM/Science Photo Library; p176: Vladimir Gjorgiev/Shutterstock; p177: Well-
without the prior permission in writing of Oxford University Press, or come UK; p177: ©Janine Wiedel/Photofusion; p179: © inhauscreative/istock;
as expressly permitted by law, by licence or under terms agreed with p179: © Richard Levine/Alamy; p180: © Underwood & Underwood/Corbis; p181:
the appropriate reprographics rights organization. Enquiries concerning MOREDUN ANIMAL HEALTH LTD/Science Photo Library; p181: LIVING ART EN-
reproduction outside the scope of the above should be sent to the Rights TERPRISES, LLC/Science Photo Library; p185: DR JEREMY BURGESS/Science Photo
Department, Oxford University Press, at the address above. Library; p186: AMI IMAGES/Science Photo Library; p186: © Frank Walker/Alamy;
p187: © blickwinkel/Alamy; p187: EYE OF SCIENCE/Science Photo Library; p188:
You must not circulate this work in any other form and you must impose
DARWIN DALE/Science Photo Library; p189: DR JEREMY BURGESS/Science Photo
this same condition on any acquirer.
Library; p190: © Peter Arnold, Inc./Alamy; p190: SUSUMU NISHINAGA/Science
British Library Cataloguing in Publication Data
Photo Library; p193: STEVE GSCHMEISSNER/Science Photo Library; p193: D.
Data available
PHILLIPS/Science Photo Library; p195: PROF. P. MOTTA/DEPT. OF ANATOMY/UNI-
978 0 19 835516 8
VERSITY; p199: ANATOMICAL TRAVELOGUE/Science Photo Library; p199: ANA-
10 9 8 7 6 5 4 3 2 1
TOMICAL TRAVELOGUE/Science Photo Library; p199: JAMES STEVENSON/Sci-
Paper used in the production of this book is a natural, recyclable product
ence Photo Library; p200: DR G. MOSCOSO/Science Photo Library; p201:
made from wood grown in sustainable forests. The manufacturing process
BlueSkyImage/Shutterstock; p201: MAURO FERMARIELLO/Science Photo Library;
conforms to the environmental regulations of the country of origin.
p202: istock; p204: DR J. P. ABEILLE/Science Photo Library; p209: © monkeybusi-
Printed in Great Britain by Bell and Bain Ltd, Glasgow nessimages/istock; p210: © sean sprague / Alamy; p210: NIAID/NATIONAL INSTI-
TUTES OF HEALTH/Science Photo Library; p214: © video1/istock; p214: CNRI/Sci-
Acknowledgements
ence Photo Library; p218: MICHEL DELARUE, ISM/Science Photo Library; p219:
Page make-up by GreenGate Publshing Services, Kent
M.I. WALKER/Science Photo Library; p219: Dimarion/Shutterstock; p220: D. PHIL-
The authors and publishers wish to thank Julietta Watson for her
LIPS/Science Photo Library; p221: PASCAL GOETGHELUCK/Science Photo Library;
assistance on the research and commenting on the manuscript and Paul
p223: © Martin Shields/Alamy; p224: © PeterAustin/istock; p226: REVY, ISM/Sci-
Connell for his work on the Alternative to practical paper section.
ence Photo Library; p227: © CuboImages srl/Alamy; p229: DAVID NICHOLLS/Sci-
The authors and publisher are grateful to the following for permission to
ence Photo Library; p229: BIOPHOTO ASSOCIATE/Science Photo Library; p232: ©
reproduce photographs in this book.
Ian Shaw/Alamy; p233: JEROME WEXLER/Science Photo Library; p234: © Christi-
Cover image: © Michael & Patricia Fogden/CORBIS; p2: © megasquib/istock; p3:
anAnthony/istock; p234: FRANCIS LEROY, BIOCOSMOS/Science Photo Library;
© Markanja/istock; p4: © Rinek/istock; p4: © Shadow_Hawk/istock; p4: © kon-
p236: Kim Fenemma/Visuals Unlimited, Inc./Getty; p236: Mirko Zanni/Getty;
mesa/istock; p6: DAVID SCHARF/Science Photo Library; p6: GREGORY DIMIJIAN/
p236: © karlumbriaco/Fotolia; p237: MAURO FERMARIELLO/Science Photo Li-
Science Photo Library; p7: M.I. WALKER/Science Photo Library; p8: Heather Angel
brary; p237: STEVE ALLEN/Science Photo Library; p238: Science Photo Library;
/ Natural Visions; p8: © Mark Kostich/istock; p8: M.H. SHARP/Science Photo Li-
p238: FLETCHER andamp;amp; BAYLIS/Science Photo Library; p238: TONY CAMA-
brary; p9: © Juanvi Carrasco / Alamy; p9: Oxford Scientic/Mike Birkhead; p10:
CHO/Science Photo Library; p240: JOHN MOSS/Science Photo Library; p240: (c)
TED KINSMAN/Science Photo Library; p10: © Lupos/istock; p10: STUART WILSON/
John Giustina; p240: (c) 2008 Michele Westmorland All Rights Reserved; p241: ©
Science Photo Library; p10: DAVID AUBREY/Science Photo Library; p11: M.H.
driftlessstudio/istock; p244: © Elliot Nichol/Alamy; p253: HUGH SPENCER/Sci-
SHARP/Science Photo Library; p11: © johnaudrey/istock; p12: SINCLAIR STAM-
ence Photo Library; p253: ANDREW SYRED/Science Photo Library; p254: © am-
MERS/Science Photo Library; p12: BJORN SVENSSON/Science Photo Library; p12:
rishwad/istock; p260: Image Source; p260: SM Raq Photography/Getty; p261:
ADRIAN BICKER/Science Photo Library; p18: Carolina Biological Supply, Co/Visu-
Adrian Muttitt / Alamy; p261: ROSENFELD IMAGES LTD/Science Photo Library;
als Unlimited, Inc.; p19: POWER AND SYRED/Science Photo Library; p21: DR GO-
p262: POWER AND SYRED/Science Photo Library; p264: © Olha Rohulya/istock;
PAL MURTI/Science Photo Library; p21: DAVID AUBREY/Science Photo Library;
p265: MAXIMILIAN STOCK LTD/Science Photo Library; p266: © chas53/istock;
p21: CNRI/Science Photo Library; p29: THOMAS DEERINCK, NCMIR/Science Pho-
p266: © Nigel Cattlin/Visuals Unlimited/Corbis; p270: © CARLOS BARRIA/Reuters/
to Library; p33: Mike Samworth.; p33: Mike Samworth.; p43: © GoGo Images
Corbis; p270: Sukpaiboonwat/Shutterstock; p271: © frei-impuls/istock; p271:
Corporation/Alamy; p43: A. BARRINGTON BROWN/Science Photo Library; p46:
Thomas Marent/Getty; p272: © osiris59/istock; p272: © jeanro/istock; p274: ©
J.C. REVY, ISM/Science Photo Library; p47: LAGUNA DESIGN/Science Photo Li-
John Potter/Alamy; p275: © davide chiarito/istock; p276: DAVID NUNUK/Science
brary; p54: BIOPHOTO ASSOCIATES/Science Photo Library; p56: Ecoimages/Foto-
Photo Library; p277: DR JEREMY BURGESS/Science Photo Library; p278: JOE
lia; p56: Science Photo Library/Cordelia Molloy; p58: MARTIN DOHRN/Science
SOHM/VISIONS OF AMERICA/Science Photo Library; p280: MARTIN BOND/Sci-
Photo Library; p58: © IslandLeigh/istock; p63: ROSENFELD IMAGES LTD/Science
ence Photo Library; p280: DIRK WIERSMA/Science Photo Library; p280: JOHN
Photo Library; p63: © Nigel Cattlin / Alamy; p64: © Roel Smart/istock; p66: GEOFF
HESELTINE/Science Photo Library; p281: WILL andamp;amp; DENI MCINTYRE/
KIDD/Science Photo Library; p73: © lo/istock; p74: © Maica/istock; p74: © image
Science Photo Library; p281: SHEILA TERRY/Science Photo Library; p281: YVES
BROKER / Alamy; p74: GUSTOIMAGES/Science Photo Library; p77: BIOPHOTO AS-
SOULABAILLE/LOOK AT SCIENCES/Science Photo Library; p282: © FABRIZIO
SOCIATES/Science Photo Library; p77: BIOPHOTO ASSOCIATES/Science Photo Li-
BENSCH/Reuters/Corbis; p282: © Olivier Coret/Corbis; p283: © George Clerk/is-
brary; p80: IAN BODDY/Science Photo Library; p85: EYE OF SCIENCE/Science
tock; p283: PETER SCOONES/Science Photo Library; p284: ROSENFELD IMAGES
Photo Library; p86: CNRI/Science Photo Library; p87: © Les Stone/Corbis; p87: Eco
LTD/Science Photo Library; p284: MARTIN BOND/Science Photo Library; p285:
Images; p90: Alamy; p90: LOUISA PRESTON/Science Photo Library; p91: Noel
Richard Fosberry; p285: © paulprescott72/istock; p285: © Lourens Smak/Alamy;
Sturt; p91: CHUCK BROWN/Science Photo Library; p91: Gene Cox; p92: POWER
p285: © kozmoat98/istock; p286: © Corbis. All Rights Reserved.; p286: Michael &
AND SYRED/Science Photo Library; p92: Gene Cox; p94: DR JEREMY BURGESS/
Patricia Fogden/Getty; p286: Richard Fosberry; p287: © Enjoylife2/istock; p287: ©
Science Photo Library; p94: BIOPHOTO ASSOCIATES/Science Photo Library; p94:
GoodOlga/istock; p288: Erick Margarita Images/Shutterstock; p288: © mkos83/is-
BIOPHOTO ASSOCIATES/Science Photo Library; p96: BIOPHOTO ASSOCIATES/Sci-
tock; p288: © Juniors Bildarchiv/Alamy; p289: SCUBAZOO/Science Photo Library;
ence Photo Library; p97: CLOUDS HILL IMAGING LTD/Science Photo Library;
p289: © National Geographic Image Collection/Alamy.
p104: RIA NOVOSTI/Science Photo Library; p105: Photo Researchers, Inc. /Science
Artwork by Greengate Publishing Services and OUP.
Photo Library; p108: BIOPHOTO ASSOCIATES/Science Photo Library; p108: CNRI/
Every effort has been made to contact all copyright holders, but if any have
Science Photo Library; p110: BIOPHOTO ASSOCIATES/Science Photo Library;
inadvertently been overlooked, the publishers will be happy to make the
p111: © ChristianAnthony/istock; p112: STEVE GSCHMEISSNER/Science Photo
necessary amendments at the first opportunity.
, Contents
Introduction 1 7.3 Balancing energy needs 74
7.4 Starvation and nutrient deciency 76
Unit 1 Characteristics and classication
7.5 Digestion 78
of living organisms 2
7.6 Teeth 80
1.1 Characteristics of living organisms 2
7.7 Mouth, oesophagus and stomach 82
1.2 Classication 4
7.8 Small intestine and absorption 84
1.3 Features of organisms 6
7.9 Large intestine and intestinal disease 86
1.4 Vertebrates 8
Practice questions 88
1.5 Invertebrates 10
Unit 8 Plant transport 90
1.6 Ferns and owering plants 12
1.7 Dichotomous keys 14 8.1 Transport systems 90
Practice questions 16 8.2 Water uptake 92
8.3 Transpiration 94
Unit 2 Cells 18
8.4 Translocation 96
2.1 Structure of cells 18
Practice questions 98
2.2 Cell organelles 20
Unit 9 Transport in humans 100
2.3 Different types of cell 22
2.4 Levels of organisation 24 9.1 Circulation 100
Practice questions 26 9.2 The heart 102
9.3 Heart and exercise 104
Unit 3 Movement in and out of cells 28
9.4 Blood vessels 106
3.1 Diffusion 28
9.5 Coronary heart disease (CHD) 108
3.2 Osmosis 30
9.6 Blood 110
3.3 Osmosis in plant and animal cells 32
9.7 Blood in defence 112
3.4 Active transport 34
9.8 Lymph and tissue uid 114
Practice questions 36
Practice questions 116
Unit 4 Biological molecules 38
Unit 10 Diseases and immunity 118
4.1 Biological molecules 38
10.1 Disease 118
4.2 Chemical tests for biological molecules 40
10.2 Defence against disease 120
4.3 DNA 42
10.3 Aspects of immunity 122
Practice questions 44
10.4 Controlling the spread of disease 124
Practice questions 126
Unit 5 Enzymes 46
5.1 Structure and action of enzymes 46 Unit 11 Gas exchange in humans 128
5.2 Factors affecting enzyme action:
11.1 The gas exchange system 128
temperature 48
11.2 Gas exchange 130
5.3 Enzymes and pH 50
11.3 Breathing 132
Practice questions 52
11.4 Rate and depth of breathing 134
Practice questions 136
Unit 6 Plant nutrition 54
6.1 Photosynthesis 54 Unit 12 Respiration 138
6.2 What is needed for photosynthesis? 56
12.1 Aerobic respiration 138
6.3 Products of photosynthesis 58
12.2 Anaerobic respiration 140
6.4 Rate of photosynthesis 60
Practice questions 142
6.5 Glasshouse production 62
Unit 13 Excretion 144
6.6 Leaves 64
6.7 Mineral requirements 66 13.1 Excretion 144
Practice questions 68 13.2 Kidney structure 146
13.3 Kidney function 148
Unit 7 Animal nutrition 70
13.4 Kidney dialysis and kidney transplants 150
7.1 A balanced diet 70
Practice questions 152
7.2 Sources of nutrients 72
iii
, Contents
Unit 14 Coordination and response 154 Unit 18 Variation and selection 232
14.1 Nervous control in humans 154 18.1 Variation 232
14.2 Neurones and reex arcs 156 18.2 Mutations 234
14.3 Synapses and drugs 158 18.3 Adaptive features 236
14.4 Sense organs 160 18.4 Natural selection 238
14.5 The eye 162 18.5 Selective breeding 240
14.6 Hormones 164 Practice questions 242
14.7 Controlling conditions in the body 166
Unit 19 Organisms and their environment 244
14.8 Controlling body temperature 168
19.1 Energy ow 244
14.9 Tropic responses 170
19.2 Pyramids of numbers and biomass 246
Practice questions 172
19.3 Shortening the food chain 248
Unit 15 Drugs 174
19.4 Nutrient cycles 250
15.1 Drugs 174 19.5 The nitrogen cycle 252
15.2 Heroin 176 19.6 Populations, communities and
15.3 Alcohol and the misuse of drugs ecosystems 254
in sport 178 19.7 Human populations 256
15.4 Smoking and health 180 Practice questions 258
Practice questions 182
Unit 20 Biotechnology and genetic
Unit 16 Reproduction 184 engineering 260
16.1 Asexual and sexual reproduction 184 20.1 Microorganisms and biotechnology 260
16.2 Flower structure 186 20.2 Enzymes and biotechnology 262
16.3 Pollination 188 20.3 Fermenters 264
16.4 Fertilisation and seed formation 190 20.4 Genetic engineering 266
16.5 The male reproductive system 192 Practice questions 268
16.6 The female reproductive system 194
Unit 21 Human inuences on ecosystems 270
16.7 Fertilisation and implantation 196
21.1 Food supply 270
16.8 Pregnancy 198
21.2 Habitat destruction 272
16.9 Ante-natal care and birth 200
21.3 Pollution 274
16.10 Sex hormones 202
21.4 Water pollution 276
16.11 The menstrual cycle 204
21.5 The greenhouse effect 278
16.12 Methods of birth control 206
21.6 Acid rain 280
16.13 Control of fertility 208
21.7 Sustainable resources 282
16.14 Sexually transmitted infections (STIs) 210
21.8 Sewage treatment and recycling 284
Practice questions 212
21.9 Endangered species 286
Unit 17 Inheritance 214
21.10 Conservation 288
17.1 Chromosomes, genes and DNA 214 Practice questions 290
17.2 Protein synthesis 216 Alternative to practical paper 292
17.3 Mitosis 218 Glossary 298
17.4 Meiosis 220 Index 307
17.5 Inheritance and genes 222
17.6 Monohybrid inheritance 224
17.7 Codominance 226
17.8 Sex linkage 228
Practice questions 230
iv