THE ULTIMATE GUIDE TO PHARMACOLOGY NURSING PRACTICE
QUESTIONS FOR NCLEX 2025-2026
50 MCQs with Explanations:
1. Which of the following medications is used to treat hypertension by blocking angiotensin II
receptors?
A. Lisinopril
B. Losartan
C. Metoprolol
D. Furosemide
Answer: B. Losartan
Explanation: Losartan is an angiotensin II receptor blocker (ARB), while lisinopril is an ACE
inhibitor.
2. A patient is prescribed warfarin. Which laboratory value should the nurse monitor closely?
A. Hemoglobin
B. Platelet count
C. International Normalized Ratio (INR)
D. Blood glucose
Answer: C. International Normalized Ratio (INR)
Explanation: INR is used to monitor the effectiveness of warfarin therapy.
3. Which medication is contraindicated in a patient with a sulfa allergy?
A. Metformin
B. Furosemide
C. Acetaminophen
D. Ibuprofen
Answer: B. Furosemide
Explanation: Furosemide is a sulfonamide derivative and can cause allergic reactions in patients
with sulfa allergies.
4. A patient is prescribed digoxin. Which symptom should the nurse teach the patient to
report immediately?
A. Headache
B. Blurred vision
C. Mild nausea
D. Fatigue
, Answer: B. Blurred vision
Explanation: Blurred vision is a sign of digoxin toxicity.
5. Which medication is used to reverse the effects of heparin?
A. Vitamin K
B. Protamine sulfate
C. Naloxone
D. Flumazenil
Answer: B. Protamine sulfate
Explanation: Protamine sulfate is the antidote for heparin.
6. A patient is prescribed metformin for type 2 diabetes. Which instruction should the nurse
provide?
A. Take with meals to reduce gastrointestinal upset.
B. Avoid all carbohydrates.
C. Stop taking the medication if blood sugar is normal.
D. Take on an empty stomach for better absorption.
Answer: A. Take with meals to reduce gastrointestinal upset.
Explanation: Metformin should be taken with meals to minimize side effects like nausea and
diarrhea.
7. Which medication is used to treat opioid overdose?
A. Flumazenil
B. Naloxone
C. Acetylcysteine
D. Atropine
Answer: B. Naloxone
Explanation: Naloxone is an opioid antagonist used to reverse opioid overdose.
8. A patient is prescribed albuterol. What is the primary action of this medication?
A. Reduce inflammation
B. Bronchodilation
C. Suppress cough
D. Decrease mucus production
Answer: B. Bronchodilation
Explanation: Albuterol is a beta-2 agonist that relaxes bronchial smooth muscle.
QUESTIONS FOR NCLEX 2025-2026
50 MCQs with Explanations:
1. Which of the following medications is used to treat hypertension by blocking angiotensin II
receptors?
A. Lisinopril
B. Losartan
C. Metoprolol
D. Furosemide
Answer: B. Losartan
Explanation: Losartan is an angiotensin II receptor blocker (ARB), while lisinopril is an ACE
inhibitor.
2. A patient is prescribed warfarin. Which laboratory value should the nurse monitor closely?
A. Hemoglobin
B. Platelet count
C. International Normalized Ratio (INR)
D. Blood glucose
Answer: C. International Normalized Ratio (INR)
Explanation: INR is used to monitor the effectiveness of warfarin therapy.
3. Which medication is contraindicated in a patient with a sulfa allergy?
A. Metformin
B. Furosemide
C. Acetaminophen
D. Ibuprofen
Answer: B. Furosemide
Explanation: Furosemide is a sulfonamide derivative and can cause allergic reactions in patients
with sulfa allergies.
4. A patient is prescribed digoxin. Which symptom should the nurse teach the patient to
report immediately?
A. Headache
B. Blurred vision
C. Mild nausea
D. Fatigue
, Answer: B. Blurred vision
Explanation: Blurred vision is a sign of digoxin toxicity.
5. Which medication is used to reverse the effects of heparin?
A. Vitamin K
B. Protamine sulfate
C. Naloxone
D. Flumazenil
Answer: B. Protamine sulfate
Explanation: Protamine sulfate is the antidote for heparin.
6. A patient is prescribed metformin for type 2 diabetes. Which instruction should the nurse
provide?
A. Take with meals to reduce gastrointestinal upset.
B. Avoid all carbohydrates.
C. Stop taking the medication if blood sugar is normal.
D. Take on an empty stomach for better absorption.
Answer: A. Take with meals to reduce gastrointestinal upset.
Explanation: Metformin should be taken with meals to minimize side effects like nausea and
diarrhea.
7. Which medication is used to treat opioid overdose?
A. Flumazenil
B. Naloxone
C. Acetylcysteine
D. Atropine
Answer: B. Naloxone
Explanation: Naloxone is an opioid antagonist used to reverse opioid overdose.
8. A patient is prescribed albuterol. What is the primary action of this medication?
A. Reduce inflammation
B. Bronchodilation
C. Suppress cough
D. Decrease mucus production
Answer: B. Bronchodilation
Explanation: Albuterol is a beta-2 agonist that relaxes bronchial smooth muscle.
