NURS 5334
NURS
Antimicrobials
5334
NURS
Antimicrobials
5334
Part 3Antimicrobials
Antimycobacterials
Part 3 Antimycobacterials
Part 3and
Antimycobacterials
Antifungals
and Antifungals
Latest
and2025_2026
Antifungals
Latest 2025_2026
with
Latest
Real2025_2026
Questions
with Real Questions
with
and Real
Detailed
Questions
andAnswers.pdf
Detailed
andAnswers.pdf
Detailed Answers.pdf
NURS 5334 Antimicrobials Part 3
Antimycobacterials and Antifungals
Latest 2025/2026 with Real Questions
and Detailed Answers
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
NURS 5334
NURS
Antimicrobials
5334
NURS
Antimicrobials
5334
Part 3Antimicrobials
Antimycobacterials
Part 3 Antimycobacterials
Part 3and
Antimycobacterials
Antifungals
and Antifungals
Latest
and2025_2026
Antifungals
Latest 2025_2026
with
Latest
Real2025_2026
Questions
with Real Questions
with
and Real
Detailed
Questions
andAnswers.pdf
Detailed
andAnswers.pdf
Detailed Answers.pdf
,Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
Terms in this set (67)
Mycobacteria acid fast bacteria: cause slow growing lesions in body
Mycobacterium tuberculosis can cause latent and active TB infection
leading cause of death worldwide
requires txt for months-yrs
txt for 9m with INH or 12m weekly with INH/Rifampin
multidrug resistance for TB is txt for 2 y
TB drugs Isoniazid (INH) PROTYPE DRUG
ethambutol
rifampin
pyrazinamide
Rifapetine
Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
,Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
Xremely drug resistant TB resists INH, Rifampin, Fluoroquinolones, Amikacin, Kanamycin, Capreomycin
TXT: Rifabutin or Rifapentine (may need drugs much longer)
Standard Resistant TB treatment regimen INH, Rifampin, Ethambutol, Pyrazinamide (8 wks)
INH, Rifampin (16 wks)
DOT therapy
Isoniazid (INH) MOA: stop enzymes for acid synthesis leading to cell wall destruction
Take on empty stomach
ADEs: hepatitis, paresthesias in hands/feet, convulsions, rash, fever
- Liver toxicity (hepato) check liver fxn
- Don't take with alcohol (liver fxn remember?)
Rifamycins Rifampin (broader coverage than INH)
Rifabutin
Rifapentine
1s line macrocyclic abx for TB
Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
, Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
Rifampin (Rifadin) MOA: Bactericidal: blocks RNA transcription
USE: TB, meningitis, Leprosy
Concentrates in CSF
Induces CYP450 drugs and reduced their 1/2 life (like methadone - causing
withdrawl symptoms)
Eliminates in Bile/Feces/Urine (orange-red color)
Contact lenses stain orange-red
ADEs: n/v, rash, hepatitis/liver fail, flu symptoms-fever/chill/muscle ache, drug
interactions
Get baseline LFTs and CBC
Rifabutin Derivative of Rifampin
prefered to txt TB in patients with HIV, NNRTIs
less potent inducer of CYP450
ADEs: similar to Rifampin, but also uveitis, neutropenia, hyperpigmentation
Rifapentine longer 1/2 life than Rifampin
combo with INH for latent TB
Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
NURS
Antimicrobials
5334
NURS
Antimicrobials
5334
Part 3Antimicrobials
Antimycobacterials
Part 3 Antimycobacterials
Part 3and
Antimycobacterials
Antifungals
and Antifungals
Latest
and2025_2026
Antifungals
Latest 2025_2026
with
Latest
Real2025_2026
Questions
with Real Questions
with
and Real
Detailed
Questions
andAnswers.pdf
Detailed
andAnswers.pdf
Detailed Answers.pdf
NURS 5334 Antimicrobials Part 3
Antimycobacterials and Antifungals
Latest 2025/2026 with Real Questions
and Detailed Answers
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
NURS 5334
NURS
Antimicrobials
5334
NURS
Antimicrobials
5334
Part 3Antimicrobials
Antimycobacterials
Part 3 Antimycobacterials
Part 3and
Antimycobacterials
Antifungals
and Antifungals
Latest
and2025_2026
Antifungals
Latest 2025_2026
with
Latest
Real2025_2026
Questions
with Real Questions
with
and Real
Detailed
Questions
andAnswers.pdf
Detailed
andAnswers.pdf
Detailed Answers.pdf
,Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
Terms in this set (67)
Mycobacteria acid fast bacteria: cause slow growing lesions in body
Mycobacterium tuberculosis can cause latent and active TB infection
leading cause of death worldwide
requires txt for months-yrs
txt for 9m with INH or 12m weekly with INH/Rifampin
multidrug resistance for TB is txt for 2 y
TB drugs Isoniazid (INH) PROTYPE DRUG
ethambutol
rifampin
pyrazinamide
Rifapetine
Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
,Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
Xremely drug resistant TB resists INH, Rifampin, Fluoroquinolones, Amikacin, Kanamycin, Capreomycin
TXT: Rifabutin or Rifapentine (may need drugs much longer)
Standard Resistant TB treatment regimen INH, Rifampin, Ethambutol, Pyrazinamide (8 wks)
INH, Rifampin (16 wks)
DOT therapy
Isoniazid (INH) MOA: stop enzymes for acid synthesis leading to cell wall destruction
Take on empty stomach
ADEs: hepatitis, paresthesias in hands/feet, convulsions, rash, fever
- Liver toxicity (hepato) check liver fxn
- Don't take with alcohol (liver fxn remember?)
Rifamycins Rifampin (broader coverage than INH)
Rifabutin
Rifapentine
1s line macrocyclic abx for TB
Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
, Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
Rifampin (Rifadin) MOA: Bactericidal: blocks RNA transcription
USE: TB, meningitis, Leprosy
Concentrates in CSF
Induces CYP450 drugs and reduced their 1/2 life (like methadone - causing
withdrawl symptoms)
Eliminates in Bile/Feces/Urine (orange-red color)
Contact lenses stain orange-red
ADEs: n/v, rash, hepatitis/liver fail, flu symptoms-fever/chill/muscle ache, drug
interactions
Get baseline LFTs and CBC
Rifabutin Derivative of Rifampin
prefered to txt TB in patients with HIV, NNRTIs
less potent inducer of CYP450
ADEs: similar to Rifampin, but also uveitis, neutropenia, hyperpigmentation
Rifapentine longer 1/2 life than Rifampin
combo with INH for latent TB
Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf Nurs 5334 Antimicrobials Part 3_ Antimycobacterials, Antifungals.pdf
