Solvents dipolemoments
Nonpolar Aprotic
notgenerally useful forruns
Far very
Aprotic
useful for rxns
proticsolvents
have N H 0
bondswhich
enable Hbonds
Borderline Aprotic polar proti
veryuseful for rxns reactive only forspecificrxns
Petroleumether mixture Is a mixture of mostly hexane
isomers butwill includepentane
heptane molecules
Toluene PhCH 3 High boiling 110C
Chloroform HCl a Halogenated solvent toxicity issues
mean it is notusedoften Replacedby
Cl Cl DCM
Dichloromethane CH Cl Halogenated solvent lesstoxicthan
Ymhethylene
HCl low boilingpoint 40C
chloride non flammable
Diethylether Etzo Low boiling point 35C
ther flamma le
O
highly
Tetrahydrofuran Medium boiling point 66c extremely
THF useful solvent
0
0 Esterfunctional group common rxn
Ethyl acetate EtOAc
work up solvent Medium boiling
0 point 77 C
Acetone ACCH 0 Common but not in rxns difficult to
dry ketone functionalgroup
reactive to nucleophiles
Nonpolar Aprotic
notgenerally useful forruns
Far very
Aprotic
useful for rxns
proticsolvents
have N H 0
bondswhich
enable Hbonds
Borderline Aprotic polar proti
veryuseful for rxns reactive only forspecificrxns
Petroleumether mixture Is a mixture of mostly hexane
isomers butwill includepentane
heptane molecules
Toluene PhCH 3 High boiling 110C
Chloroform HCl a Halogenated solvent toxicity issues
mean it is notusedoften Replacedby
Cl Cl DCM
Dichloromethane CH Cl Halogenated solvent lesstoxicthan
Ymhethylene
HCl low boilingpoint 40C
chloride non flammable
Diethylether Etzo Low boiling point 35C
ther flamma le
O
highly
Tetrahydrofuran Medium boiling point 66c extremely
THF useful solvent
0
0 Esterfunctional group common rxn
Ethyl acetate EtOAc
work up solvent Medium boiling
0 point 77 C
Acetone ACCH 0 Common but not in rxns difficult to
dry ketone functionalgroup
reactive to nucleophiles
