NURSNURS
5334 Antimicrobials
NURS
5334 Antimicrobials
5334 Antimicrobials
Part 2_Part
Protein
2_Part
Protein
Synthesis
2_ Protein
Synthesis
Inhibitors,
Synthesis
Inhibitors,
Quinolones,
Inhibitors,
Quinolones,
Folic
Quinolones,
Acid
FolicAntagonists
Acid
FolicAntagonists
Acid &Antagonists
Urinary
& Urinary
Tract
& Urinary
Antibiotics
Tract Antibiotics
TractStudy
Antibiotics
Guide.pdf
Study Guide.pdf
Study Guide.pdf
NURS 5334 Antimicrobials Part 2:
Protein Synthesis Inhibitors,
Quinolones, Folic Acid Antagonists &
Urinary Tract Antibiotics Study Guide
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
NURSNURS
5334 Antimicrobials
NURS
5334 Antimicrobials
5334 Antimicrobials
Part 2_Part
Protein
2_Part
Protein
Synthesis
2_ Protein
Synthesis
Inhibitors,
Synthesis
Inhibitors,
Quinolones,
Inhibitors,
Quinolones,
Folic
Quinolones,
Acid
FolicAntagonists
Acid
FolicAntagonists
Acid &Antagonists
Urinary
& Urinary
Tract
& Urinary
Antibiotics
Tract Antibiotics
TractStudy
Antibiotics
Guide.pdf
Study Guide.pdf
Study Guide.pdf
,Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
What does being selective for bacterial
3 Glycylcyclines 4
ribosomes do for ABX
Don't know?
Terms in this set (63)
Protein synthesis inhibitors aminoglycosides, macrolides, tetracyclines, glycylcyclines, macrolytics,
lincosamides, oxazolidinones
Bacteriostatic ABX that target the ribosome to prevent bacterial protein
synthesis
What does being selective for bacterial ribosomes do helps decrease potential ADEs from disrupting protein synthesis in the
for ABX host
(in high doses these drugs can be toxic from interaction with mitochondria)
Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
,Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
Tetracyclines Tetracycline PROTOYTPE DRUG
Doxycycline
Minocycline
MOA: Bacteriostatic: use passive diffusion to enter bacteria and stop tRNA
from binding with mRNA inhibiting protein synthesis
USE: usually for chlamydia, gram + & -, protozoa, mycobacteria, atypical
species
Resistance: efflux pump that expels drug from cell, bacterial proteins, or
enzyme inactivation
ADEs: GI upset, esophagitis, discolored teeth, stunted growth, liver toxicity in
pregnant or CKD, dizzy, vertigo, tinnitus, HA, blur vision
Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
, Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
Tetracyclines Pharmakokinetics Absorb well orally (dont give with dairy, Mag, Ca, Iron, antacids)
Distribute to liver, kidney, saliva (high levels in saliva and tears - cross
placenta, concentrate in bone/teeth)
Tetracycline Eliminates in urine, Doxycycline in feces (use this for CKD)
Contraindications: dont give to kids, breasfeeding, pregnancy
Can cause severe sunburn
Sarecycline (Saycera) newest tetracycline
used for acne vulgars: long half life
ADE: pseudotumor cerebri, blur vision, change in green/blue perception
(get baseline eye exam prior to start)
Glycylcyclines Tigecycline (PROTOYPE DRUG) - derivative of Minocycline (IV ONLY)
MOA: Bacteriostatic: bind to ribosome to stop protein synthesis
Used for soft tissue and intra-abdominal infection
Broad Spectrum: MRSA, multi-drug resistant Strep, VRE, β-lactamase-
producing gram - bacteria, Acinetobacter Baumanii
Resistance: overexpressed efflux pumps
ADEs: n/v, pancreatitis (deadly), high LFTs, high CRT, photosensitivity,
pseudomotor cerebral, fetal harm bones/teeth
BBW: only give if other txt is not an option
Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
5334 Antimicrobials
NURS
5334 Antimicrobials
5334 Antimicrobials
Part 2_Part
Protein
2_Part
Protein
Synthesis
2_ Protein
Synthesis
Inhibitors,
Synthesis
Inhibitors,
Quinolones,
Inhibitors,
Quinolones,
Folic
Quinolones,
Acid
FolicAntagonists
Acid
FolicAntagonists
Acid &Antagonists
Urinary
& Urinary
Tract
& Urinary
Antibiotics
Tract Antibiotics
TractStudy
Antibiotics
Guide.pdf
Study Guide.pdf
Study Guide.pdf
NURS 5334 Antimicrobials Part 2:
Protein Synthesis Inhibitors,
Quinolones, Folic Acid Antagonists &
Urinary Tract Antibiotics Study Guide
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
NURSNURS
5334 Antimicrobials
NURS
5334 Antimicrobials
5334 Antimicrobials
Part 2_Part
Protein
2_Part
Protein
Synthesis
2_ Protein
Synthesis
Inhibitors,
Synthesis
Inhibitors,
Quinolones,
Inhibitors,
Quinolones,
Folic
Quinolones,
Acid
FolicAntagonists
Acid
FolicAntagonists
Acid &Antagonists
Urinary
& Urinary
Tract
& Urinary
Antibiotics
Tract Antibiotics
TractStudy
Antibiotics
Guide.pdf
Study Guide.pdf
Study Guide.pdf
,Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
What does being selective for bacterial
3 Glycylcyclines 4
ribosomes do for ABX
Don't know?
Terms in this set (63)
Protein synthesis inhibitors aminoglycosides, macrolides, tetracyclines, glycylcyclines, macrolytics,
lincosamides, oxazolidinones
Bacteriostatic ABX that target the ribosome to prevent bacterial protein
synthesis
What does being selective for bacterial ribosomes do helps decrease potential ADEs from disrupting protein synthesis in the
for ABX host
(in high doses these drugs can be toxic from interaction with mitochondria)
Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
,Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
Tetracyclines Tetracycline PROTOYTPE DRUG
Doxycycline
Minocycline
MOA: Bacteriostatic: use passive diffusion to enter bacteria and stop tRNA
from binding with mRNA inhibiting protein synthesis
USE: usually for chlamydia, gram + & -, protozoa, mycobacteria, atypical
species
Resistance: efflux pump that expels drug from cell, bacterial proteins, or
enzyme inactivation
ADEs: GI upset, esophagitis, discolored teeth, stunted growth, liver toxicity in
pregnant or CKD, dizzy, vertigo, tinnitus, HA, blur vision
Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
, Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
Tetracyclines Pharmakokinetics Absorb well orally (dont give with dairy, Mag, Ca, Iron, antacids)
Distribute to liver, kidney, saliva (high levels in saliva and tears - cross
placenta, concentrate in bone/teeth)
Tetracycline Eliminates in urine, Doxycycline in feces (use this for CKD)
Contraindications: dont give to kids, breasfeeding, pregnancy
Can cause severe sunburn
Sarecycline (Saycera) newest tetracycline
used for acne vulgars: long half life
ADE: pseudotumor cerebri, blur vision, change in green/blue perception
(get baseline eye exam prior to start)
Glycylcyclines Tigecycline (PROTOYPE DRUG) - derivative of Minocycline (IV ONLY)
MOA: Bacteriostatic: bind to ribosome to stop protein synthesis
Used for soft tissue and intra-abdominal infection
Broad Spectrum: MRSA, multi-drug resistant Strep, VRE, β-lactamase-
producing gram - bacteria, Acinetobacter Baumanii
Resistance: overexpressed efflux pumps
ADEs: n/v, pancreatitis (deadly), high LFTs, high CRT, photosensitivity,
pseudomotor cerebral, fetal harm bones/teeth
BBW: only give if other txt is not an option
Nurs 5334 Antimicrobials Part 2_ Protein Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones,Nurs
Folic5334
AcidAntimicrobials
Antagonists, Urinary
Part 2_Tract
Protein
Abx.pdf
Synthesis Inhibitors, Quinolones, Folic Acid Antagonists, Urinary Tract Abx.pdf
