NURS 5334 Antimicrobials _ Comprehensive
NURS 5334 Nursing
Antimicrobials
Pharmacology
_ Comprehensive
Study
NURSGuide.pdf
5334Nursing
Antimicrobials
Pharmacology
_ Comprehensive
Study Guide.pdf
Nursing Pharmacology Study Guide.pdf
NURS 5334 Antimicrobials |
Comprehensive Nursing Pharmacology
Study Guide
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
NURS 5334 Antimicrobials _ Comprehensive
NURS 5334 Nursing
Antimicrobials
Pharmacology
_ Comprehensive
Study
NURSGuide.pdf
5334Nursing
Antimicrobials
Pharmacology
_ Comprehensive
Study Guide.pdf
Nursing Pharmacology Study Guide.pdf
,NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
Don't know?
Terms in this set (161)
Peak highest concentration indicates if dosage is too high and potentially toxic
Trough lowest concentration measured just before next dose. Confirms that
concentration remains above minimum effective level throughout dosing
period.
First Pass Metabolism Concentration of drug is significantly reduced by liver and GI before it
reaches bloodstream.
If more stable to 1st pass- lower doses are needed bc more drug reaches
systemic circulation with higher bioavailability.
NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
,NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
Antithymocyte Globulin used at time of transplant to prevent early rejection or in severe rejection or
steroid resistant.
Thyroglobulin-rabbit
Atgam- horse
Basiliximab (Simulect) Prevents acute kidney rejection. Inhibits ability to activate t-cell response.
Used in induction as apposed to rejection.
Alemtuzumab (Monoclonal) Causes B/T cell depletion. Used in transplant induction and
antirejection. Treats MS/ CLL
Rituximab B-cell depletion. B-cell lymphoma, post-transplant lymphoproliferative
disease, RA. BB warning: reactivation of JC virus and Hep B.
Bortezomib proteasome inhibitor that causes cell cycle arrest and apoptosis of normal
plasma cells thus decreasing bodies ability to make antibodies. Metabolized.
by CYP450.
NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
, NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
IVIG inhibits binding of antibodies to transplanted organ and activation of
complement.
Used for pretransplant desensitization and treating AMR (antibody-mediated
rejection)
Calcineurin inhibitors Cyclosporine (CYA)
Tacrolimus- renal, liver, cardiac organ transplant.
trough levels.
renal toxicity.
Costimulation Blockers prevents immune system (t-cells) from attacking a transplanted organ. Also,
approved for treating autoimmune disorders (RA)
Belatacept- organ rejection
Abatacept- RA
Draw titers for EBV prior to administration
mTOR Inhibitors suppress immune system and treat cancer.
Rapamycin- cardiac stents
Everolimus- breast cancer
NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
NURS 5334 Nursing
Antimicrobials
Pharmacology
_ Comprehensive
Study
NURSGuide.pdf
5334Nursing
Antimicrobials
Pharmacology
_ Comprehensive
Study Guide.pdf
Nursing Pharmacology Study Guide.pdf
NURS 5334 Antimicrobials |
Comprehensive Nursing Pharmacology
Study Guide
Guidehttps://www.stuvia.com/dashboard!@_)#*)(@$)($@*($@)($@*_
NURS 5334 Antimicrobials _ Comprehensive
NURS 5334 Nursing
Antimicrobials
Pharmacology
_ Comprehensive
Study
NURSGuide.pdf
5334Nursing
Antimicrobials
Pharmacology
_ Comprehensive
Study Guide.pdf
Nursing Pharmacology Study Guide.pdf
,NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
Don't know?
Terms in this set (161)
Peak highest concentration indicates if dosage is too high and potentially toxic
Trough lowest concentration measured just before next dose. Confirms that
concentration remains above minimum effective level throughout dosing
period.
First Pass Metabolism Concentration of drug is significantly reduced by liver and GI before it
reaches bloodstream.
If more stable to 1st pass- lower doses are needed bc more drug reaches
systemic circulation with higher bioavailability.
NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
,NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
Antithymocyte Globulin used at time of transplant to prevent early rejection or in severe rejection or
steroid resistant.
Thyroglobulin-rabbit
Atgam- horse
Basiliximab (Simulect) Prevents acute kidney rejection. Inhibits ability to activate t-cell response.
Used in induction as apposed to rejection.
Alemtuzumab (Monoclonal) Causes B/T cell depletion. Used in transplant induction and
antirejection. Treats MS/ CLL
Rituximab B-cell depletion. B-cell lymphoma, post-transplant lymphoproliferative
disease, RA. BB warning: reactivation of JC virus and Hep B.
Bortezomib proteasome inhibitor that causes cell cycle arrest and apoptosis of normal
plasma cells thus decreasing bodies ability to make antibodies. Metabolized.
by CYP450.
NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
, NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
IVIG inhibits binding of antibodies to transplanted organ and activation of
complement.
Used for pretransplant desensitization and treating AMR (antibody-mediated
rejection)
Calcineurin inhibitors Cyclosporine (CYA)
Tacrolimus- renal, liver, cardiac organ transplant.
trough levels.
renal toxicity.
Costimulation Blockers prevents immune system (t-cells) from attacking a transplanted organ. Also,
approved for treating autoimmune disorders (RA)
Belatacept- organ rejection
Abatacept- RA
Draw titers for EBV prior to administration
mTOR Inhibitors suppress immune system and treat cancer.
Rapamycin- cardiac stents
Everolimus- breast cancer
NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf NURS 5334 Antimicrobials.pdf
