Bps 319 Lecture 1 + 2 - Intro & Rates Of
Processes Questions With Correct Answers
False; The therapeutic range represents the optimum concentrations for MOST, BUT NOT ALL
people T or F: The therapeutic range represents the optimum concentrations for all people
therapeutic index the ratio between the toxic and therapeutic concentrations of a drug
TD50 toxic dose that will kill 50% of the population
ED50 effective dose that makes the desired therapeutic effect in 50% of the population
B, because there is a large difference between the toxic and the effective dose. From 1 mg to 100
mgs, drug B is safe If TIa = 10 and TIb = 100, which drug is safer?
pharmacokinetics the study of the time course of drug absorption, distribution,
metabolism, and excretion (what the body does to the drug)
the concentration of the drug at the site of action (Csite) What drives the response?
The plasma concentrations because blood can be easily and frequently sampled.
It is the central fluid where absorption ends and distribution and elimination begin
, Plasma is often, but not always in equilibrium with Csite Where is it easiest to measure
drug concentrations?
Plasma is used because it is much more homogenous than blood Why is plasma used, not
blood?
Plasma is used because it is obtained by centrifugation from non-clotted blood, while serum is
obtained from clotted blood. Therefore, the serum is similar to plasma but it is missing the
clotting proteins Why is plasma used, not serum?
True T or F: Every drug that passes through the GI tract must also pass through the liver
before it gets into systemic circulation
elimination the removal of the drug from the body
includes metabolism and excretion
drug absorption the process that enables an administered drug to reach the blood or
systemic circulation
GI membrane How is a drug contained in a tablet that is swallowed absorbed?
IV, because it is administered directly into the blood Which route of drug administration
bypasses absorption?
Processes Questions With Correct Answers
False; The therapeutic range represents the optimum concentrations for MOST, BUT NOT ALL
people T or F: The therapeutic range represents the optimum concentrations for all people
therapeutic index the ratio between the toxic and therapeutic concentrations of a drug
TD50 toxic dose that will kill 50% of the population
ED50 effective dose that makes the desired therapeutic effect in 50% of the population
B, because there is a large difference between the toxic and the effective dose. From 1 mg to 100
mgs, drug B is safe If TIa = 10 and TIb = 100, which drug is safer?
pharmacokinetics the study of the time course of drug absorption, distribution,
metabolism, and excretion (what the body does to the drug)
the concentration of the drug at the site of action (Csite) What drives the response?
The plasma concentrations because blood can be easily and frequently sampled.
It is the central fluid where absorption ends and distribution and elimination begin
, Plasma is often, but not always in equilibrium with Csite Where is it easiest to measure
drug concentrations?
Plasma is used because it is much more homogenous than blood Why is plasma used, not
blood?
Plasma is used because it is obtained by centrifugation from non-clotted blood, while serum is
obtained from clotted blood. Therefore, the serum is similar to plasma but it is missing the
clotting proteins Why is plasma used, not serum?
True T or F: Every drug that passes through the GI tract must also pass through the liver
before it gets into systemic circulation
elimination the removal of the drug from the body
includes metabolism and excretion
drug absorption the process that enables an administered drug to reach the blood or
systemic circulation
GI membrane How is a drug contained in a tablet that is swallowed absorbed?
IV, because it is administered directly into the blood Which route of drug administration
bypasses absorption?
