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Creams and Ointments
Created @January 28, 2025 12:57 PM
Class Molecules to Medicine
Pharmaceutical Emulsions
Oral/rectal/topical oil administration and oil soluble drugs
Formulation of oil and water- soluble drugs together
Improve palatability of oils by disguising taste and general oiliness
More absorption of oil and oil-soluble drugs in intestinal walls
Intramuscular vaccination of vaccine that’s water soluble, results in slower
drug release and increased antibody response
TPN- Method of nutrition administration as a last resort
Emulsion Types
Oil in water
For oral and intravenous administration
Topical application
Less greasy
Easily washed off
Acceptable in cosmetics
Water in Oil
Intramuscular
Creams and Ointments 1
, Topical can be easily rubbed on to skin
Hydrates skin
Water in oil in water
Delayed action
Emulsifying Agents
Emulsifying agent solubility
More soluble in water than oil in water
More soluble in oil than water in oil
Properties
No colour, odour or taste
Not toxic
Non- irritant
Creates stable emulsion at a low conc
PHASE INVERSION OCCURS IF SOLUBILITY IS ALTERED AFTER A
CHEMICAL IS ADDED
Natural Emulsifying Agents
Polysaccharides
Acacia
Creates thick film between oil and water preventing Coalescence
(Merging of substances)
Tragacanth
Viscosity increase
Creams and Ointments 2
Creams and Ointments
Created @January 28, 2025 12:57 PM
Class Molecules to Medicine
Pharmaceutical Emulsions
Oral/rectal/topical oil administration and oil soluble drugs
Formulation of oil and water- soluble drugs together
Improve palatability of oils by disguising taste and general oiliness
More absorption of oil and oil-soluble drugs in intestinal walls
Intramuscular vaccination of vaccine that’s water soluble, results in slower
drug release and increased antibody response
TPN- Method of nutrition administration as a last resort
Emulsion Types
Oil in water
For oral and intravenous administration
Topical application
Less greasy
Easily washed off
Acceptable in cosmetics
Water in Oil
Intramuscular
Creams and Ointments 1
, Topical can be easily rubbed on to skin
Hydrates skin
Water in oil in water
Delayed action
Emulsifying Agents
Emulsifying agent solubility
More soluble in water than oil in water
More soluble in oil than water in oil
Properties
No colour, odour or taste
Not toxic
Non- irritant
Creates stable emulsion at a low conc
PHASE INVERSION OCCURS IF SOLUBILITY IS ALTERED AFTER A
CHEMICAL IS ADDED
Natural Emulsifying Agents
Polysaccharides
Acacia
Creates thick film between oil and water preventing Coalescence
(Merging of substances)
Tragacanth
Viscosity increase
Creams and Ointments 2
