PSYC62 Midterm 1

PSYC62iMidtermi1
Psychopharmacologyi-i
iiiiiiiiiiiiiiistudyihowidrugsiaffectimood,iperception,ithinking,ioribehaviour

PsychoactiveiDrugsi-i
iiiiiiiiiiiiiiidrugsithatiaffectimood,iperception,ithinking,ioribehaviouribyiactivatingitheinervousis
ystem

BehaviouraliPharmacologyi-i
iiiiiiiiiiiiiiiusuallyisynonymousiwithipsychopharmacology.iButisometimesilimiteditoisubfieldiof
ibehaviourianalysis

Neuropsychopharmacologyi-i
iiiiiiiiiiiiiiianotheritermiforipsychopharmacology.iTheiprefixirepresentsitheinervousisystem.iThi
sitermihasiparticulariemphasisioninervousisystemifunctioning

Pharmacotherapeuticsi-i
iiiiiiiiiiiiiiipsychoactiveitreatmentsiforidisorders

Drugi-i
iiiiiiiiiiiiiiianiadministeredisubstanceithatialtersiphysiologicalifunctioning.iImpliesithatisubstanc
eimustiexhibitisufficientiefficiencyitoichangeiphysiologicaliprocess

"Administered"iexcludesisubstances...i-i
iiiiiiiiiiiiiii...imadeinaturallyiinitheibody

Inipsychopharmacology,iinstrumentaliuseioftenioccursiwith...i-i
iiiiiiiiiiiiiii...itherapeuticidrugs,iwhichiareiuseditoitreatiphysicaliorimentalidisorders

RecreationaliUsei-i
iiiiiiiiiiiiiiiusingiaidrugientirelyitoiexperienceiitsieffects

Misusei-i
iiiiiiiiiiiiiiidrugsiintendediforiinstrumentaliuse,ibutiinsteadiusedirecreationally

DrugiAbusei-i
iiiiiiiiiiiiiiidrugiuseithaticausesiharmitoiusersioriothers

Dependencei-i
iiiiiiiiiiiiiiicaniincludeiabuse,ibutiuseriexperiencesineedioriurgeitoicontinueiuse

TradeiNamei-i
iiiiiiiiiiiiiiidruginameidevelopediforidrugimarketing

GenericiNamei-i
iiiiiiiiiiiiiiinamesithatishowihowidrugsiorganizationallyifitiwithiotheridrugs.iTendsinotitoifollow
ihardirules


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,Dosei-i
iiiiiiiiiiiiiiiratioiofiamountiofidrugiperiorganism'sibodyiweight

DoseiEffectiCurvei-i
iiiiiiiiiiiiiiidepictsileveliofidrugieffectibyidose

ED50i-i
iiiiiiiiiiiiiiirepresentsitheidoseiatiwhichi50%iofianieffectiwasiobserved

Potencyi-i
iiiiiiiiiiiiiiiamountiofiaidrugiuseditoiproduceiaicertainileveliofieffect

LD50i-i
iiiiiiiiiiiiiiiED50iforilethality-doseicurve

TherapeuticiIndexi-i
iiiiiiiiiiiiiiiratioiofiaidrug'silethal-doseieffectivalueirelativeitoiitsitherapeutic-
doseieffectivalue.iOneiwayiisidivideiLD50ibyiED50.iButimostidevelopersiuseimoreiconservat
iveimethoditoiavoidioverlappingitherapeuticiandilethalityieffecticurves.iOftenidivideianiLD1ib
yiED99

Pharmacodynamicsi-i
iiiiiiiiiiiiiiihowidrugsiaffectibiologicaliactions.iMechanismiofiactioniforiaidrug

Foripsychoactiveidrugs,ibiologicaliactionsiincludes...i-i
iiiiiiiiiiiiiii...idrug'siactionsionitheinervousisystem

Mostiaddictiveirecreationalidrugsiaction...i-i
iiiiiiiiiiiiiii...irewardipathwayitoiproduceipleasurableieffects

Pharmacokineticsi-i
iiiiiiiiiiiiiiistudyiofihowidrugsipassithroughitheibody

Pharmacogeneticsi-i
iiiiiiiiiiiiiiihowigeneticidifferencesiinfluenceiaidrug'sipharmacokineticiandipharmacodynamicief
fects.iProvidesibasisiforidifferenceiinidrugiresponseibetweenipeople

ObjectiveiEffectsi-i
iiiiiiiiiiiiiiipharmacologicalieffectsithaticanibeidirectlyiobservedibyiothers.iResearchericaniindep
endentlyimeasureidrug'sieffects

SubjectiveiEffectsi-i
iiiiiiiiiiiiiiipharmacologicalieffectsithaticannotibeidirectlyiobservedibyiothers.iMeasuredibyiaski
ngiparticipantsitoidescribeieffects

Open-labelistudiesiapplyitoisituationiwhere...i-i
iiiiiiiiiiiiiii...idisguisingistudyimedicationimayihaveiimportantiethicaliconsequencesioribeiimpra
ctical


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, ExperimentaliValidityi-i
iiiiiiiiiiiiiiiaddressesilogicalidesigniofieffectiveiqualityiofiexperimentalistudy

InternaliValidityi-i
iiiiiiiiiiiiiiicontroliofivariablesithatimayiinfluenceichangesiiniaidependentivariable

ConfoundiVariablesi-i
iiiiiiiiiiiiiiivariablesiotherithaniindependentivariableithaticanicauseichangesitoidependentivariabl
es.iPlaceboigroupsicontroliforimanyiconfoundivariables

ExternaliValidityi-i
iiiiiiiiiiiiiiihowiwelliexperimentalifindingsigeneralizeibeyondiexperimentistudy

Externalivalidityipresentsilimitationsifor...i-i
iiiiiiiiiiiiiii...ianimaliresearchifindingsipresentediforihumans

Teratogensi-i
iiiiiiiiiiiiiiisubstancesiharmfulitoiaifetus

FaceiValidityi-i
iiiiiiiiiiiiiiiassessmentiofihowiwelliaimodeliresemblesitheidisorderiintendeditoistudy

ConstructiValidityi-i
iiiiiiiiiiiiiiiassessihowiwelliaistudy'simodeliapproximatesiaidisorder

PredictiveiValidityi-i
iiiiiiiiiiiiiiiaddressesihowiwelliaimodelipredictsicharacteristicsiofiaidisorder

USDAienforcesiregulationsiin...i-i
iiiiiiiiiiiiiii...ianimaliwelfareiacti(AWA)

OfficeiofiLaboratoryiAnimaliWelfareienforces...i-i
iiiiiiiiiiiiiii...ipoliciesiofiPubliciHealthiServicesi(PHS)

InstitutionaliAnimaliCareiandiUseiCommitteei(IACUC)i-i
iiiiiiiiiiiiiiioverseesiinstitution'sientireianimalicareiandiuseiprogram,iincludingiqualityiofihousin
g,iveterinaryipractices,iandiresearchipractices

Replacementi-i
iiiiiiiiiiiiiiitheiIACUCiaddressesinecessityiofiusingianimalsiforiproposedistudy.iSimilarlyiusefuli
findingsimayibeiderivediwithicells,itissues,iinvertebrates,ioricomputers.iIfithisiwereitheicase,iI
ACUCiwouldirejectitheiproposal

Reductioni-i
iiiiiiiiiiiiiiiusingiminimuminumberiofianimalsineededitoiachieveistudy'siobjective

Refinementi-i
iiiiiiiiiiiiiiitheiIACUCiattemptsitoiminimizeiandipainiandidistressiexperiencedibyitheistudyianim
als


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