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1
NR507 ADVANCED PATHOPHYSIOLOGY
MIDTERM EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS)
||ALREADY GRADED A+||NEWEST VERSION
Quiz: Hypersensitivity: Type 1
Ans: Type 1: Allergic reaction, Mediated by IgE, Inflammation due to mast cell
degranulation
Local symptoms:
-itching
-rash
Systemic symptoms:
-wheezing
Most dangerous = anaphylactic reaction
systemic response of hypotension, severe bronchoconstriction
Main treatment: epinephrine reverses the effects
Quiz: Hypersensitivity: Type 2
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2
Ans: Type 2: Cytotoxic reaction; tissue specific (ex: thyroid tissue)
Macrophages are the primary effectors cells involved
Can cause tissue damage or alter function
Grave's disease (hyperthyroidism) - example of altering thyroid function, but
does not destroy thyroid tissue
Incompatible blood type- example of cell/tissue damage that occurs; severe
transfusion reaction occurs and the transfused erythrocytes are destroyed by
agglutination or complement-mediated lysis.
Quiz: Type 1 Hypersensitivity VS. Type 2 Hypersensitivity
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3
Ans: Type 1 Hypersensitivity
Organ Specific
Antibody binds to the antigen on the cell surface
Type 2 Hypersensitivity
Not Organ Specific
Antibody binds to the soluble antigen outside the cell surface that was released
into the blood or body fluids, and the complex is then deposited in the tissues
Quiz: Hypersensitivity: Type 3 - Examples
Ans: Rheumatoid arthritis: Antigen/antibodies are deposited in the joints
Systemic Lupus Erythematosus (SLE)- very closely related to autoimmunity-
antigen/antibodies deposit in organs that cause tissue damage
Quiz: Hypersensitivity: Type 4
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4
Ans: Delayed response
Does not involve antigen/antibody complexes like Types 1, 2 and 3
Is T-cell mediated
Quiz: Differentiating Between the Rash of a Type 1 vs. Type 4
Reaction:
Ans: Type 1: Immediate hypersensitivity reactions, termed atopic dermatitis,
are usually characterized by widely distributed lesions
Type 4: Contact dermatitis (delayed hypersensitivity) consists of lesions only at
the site of contact with the allergen
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex would be poison ivy
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WhatsApp or call o Resources & Updates: [Testtrackers - Stuvia US]
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[+ 254707240657]
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whatsapp me in the number given.
1
NR507 ADVANCED PATHOPHYSIOLOGY
MIDTERM EXAM QUESTIONS AND CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS)
||ALREADY GRADED A+||NEWEST VERSION
Quiz: Hypersensitivity: Type 1
Ans: Type 1: Allergic reaction, Mediated by IgE, Inflammation due to mast cell
degranulation
Local symptoms:
-itching
-rash
Systemic symptoms:
-wheezing
Most dangerous = anaphylactic reaction
systemic response of hypotension, severe bronchoconstriction
Main treatment: epinephrine reverses the effects
Quiz: Hypersensitivity: Type 2
o
o
© 2025 TestTrackers
WhatsApp or call o Resources & Updates: [Testtrackers - Stuvia US]
o Your Success is Our Mission!
[+ 254707240657]
o For online exams and tutor expert, please
whatsapp me in the number given.
, Testtrackers
2
Ans: Type 2: Cytotoxic reaction; tissue specific (ex: thyroid tissue)
Macrophages are the primary effectors cells involved
Can cause tissue damage or alter function
Grave's disease (hyperthyroidism) - example of altering thyroid function, but
does not destroy thyroid tissue
Incompatible blood type- example of cell/tissue damage that occurs; severe
transfusion reaction occurs and the transfused erythrocytes are destroyed by
agglutination or complement-mediated lysis.
Quiz: Type 1 Hypersensitivity VS. Type 2 Hypersensitivity
o
o
© 2025 TestTrackers
WhatsApp or call o Resources & Updates: [Testtrackers - Stuvia US]
o Your Success is Our Mission!
[+ 254707240657]
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whatsapp me in the number given.
, Testtrackers
3
Ans: Type 1 Hypersensitivity
Organ Specific
Antibody binds to the antigen on the cell surface
Type 2 Hypersensitivity
Not Organ Specific
Antibody binds to the soluble antigen outside the cell surface that was released
into the blood or body fluids, and the complex is then deposited in the tissues
Quiz: Hypersensitivity: Type 3 - Examples
Ans: Rheumatoid arthritis: Antigen/antibodies are deposited in the joints
Systemic Lupus Erythematosus (SLE)- very closely related to autoimmunity-
antigen/antibodies deposit in organs that cause tissue damage
Quiz: Hypersensitivity: Type 4
o
o
© 2025 TestTrackers
WhatsApp or call o Resources & Updates: [Testtrackers - Stuvia US]
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[+ 254707240657]
o For online exams and tutor expert, please
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4
Ans: Delayed response
Does not involve antigen/antibody complexes like Types 1, 2 and 3
Is T-cell mediated
Quiz: Differentiating Between the Rash of a Type 1 vs. Type 4
Reaction:
Ans: Type 1: Immediate hypersensitivity reactions, termed atopic dermatitis,
are usually characterized by widely distributed lesions
Type 4: Contact dermatitis (delayed hypersensitivity) consists of lesions only at
the site of contact with the allergen
The key determinant is the timing of the rash:
-Type 1 = Immediate
-Type 4 = Delayed: Several days following contact, ex would be poison ivy
o
o
© 2025 TestTrackers
WhatsApp or call o Resources & Updates: [Testtrackers - Stuvia US]
o Your Success is Our Mission!
[+ 254707240657]
o For online exams and tutor expert, please
whatsapp me in the number given.
