NURS 5334 Pharmacology Module 2 Quiz

DRUGS THAT WEAKEN CELL WALL Penicillins: weaken bacterial cell wall Beta lactam ring-beta lactimases split this ring and render Pcn inactive Pen G and Pen V: Narrow spectrum good for strep and syphilis (Penicillinase sensitive) Amoxicillin/Ampicillin: broad spectrum: Strep and AOM and lyme disease in children < 8 Adverse reactions: allergic Macrolides drugs of choice for patients with allergies Narrow spectrum with penicillinase resistance Oxacillin, Nafacillin, dicloxacillin: staph aureus staff epidermis Dicloxacillin, Nafacillin, Oxacillin, can be given po Piperacillin: effective against pseudomonas and Enterobacter, Bacteroides fragilis and Klebsiella Beta Lactamase inhibitors Clavulanic acid, tazobactam, sulbactam- extend coverage when added to another antibiotic: Ampicillin/sulbactam Amoxicillin clavulanic acid Piperacillin/tazobactam-effective against pseudomonas No MRSA coverage Cephalosporins: weaken bacterial cell wall Most widely used antibiotics Like PCNs have beta lactam ring First generation: Cefadroxil, Cephalexin, cefazolin, cefadroxil mostly used for presurgical prophylaxis (mostly gram positive) Second generation: Cefoxitin (anerobeic bacteriodes fragilis); Cefaclor; Cefotetan; Cefprozil, Cefuroxime, cefmetazole,