CLINICAL CHEM FINAL TEST BANK EXAM NEWEST
EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS A NEW UPDATED VERSION LATEST
2025(VERIFIED ANSWERS) ALREADY GRADED A+
1. In which of the following disorders would the maternal serum level of 1-fetoprotein be
elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma - ANSWER-A. Neural tube defect
2. Which of the following is FALSE about PSA?
A. It is a single-chain glycoprotein
B. It is used as a tumor marker
C. It is not elevated in benign prostatic hyperplasia
D. It is quantified in serum by immunoassays - ANSWER-C. It is not elevated in benign prostatic
hyperplasia.
3. Which of the following biomarkers is elevated in nonmucinous epithelial ovarian cancer?
A. CA 15-3
B. CA 19-9
C. CA 125
D. CEA - ANSWER-C. CA 125
,4. Which of the following is a sialylated Lewis blood group antigen associated with colorectal
cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - ANSWER-D. CA 19-9
5. Which of the following biomarkers are elevated in advanced stages of breast cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
D. DUPAN-2 and Gastrin - ANSWER-C. CA 15-3 and CA 549
6. Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
D. Nuclear matrix protein - ANSWER-D. Nuclear matrix protein
7. What is the primary clinical usefulness of measuring carcinoembryonic antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - ANSWER-D. Monitoring for recurrence of colon
cancer
8. Which of the following is used to assess the usefulness of trastuzumab (Herceptin®) therapy
for breast cancer?
,A. CA 15-3
B. HER-2/neu
C. CA 125
D. Prolactin - ANSWER-B. HER-2/neu
9. Which type of HCG test would be most useful to assess a person suspected of having
testicular cancer?
A. Plasma immunoassay for intact HCG and the β-HCG subunits
B. Plasma immunoassay from the free alpha and β-HCG subunits
C. Urine assay for HCG-β core
D. Plasma immunoassay for intact HCG only - ANSWER-A. Plasma immunoassay for intact HCG
and the β-HCG subunits
10. A markedly elevated serum AFP is associated with which of the following?
A. Ovarian cancer
B. Lung cancer
C. Hepatoma
D. Breast cancer - ANSWER-C. Hepatoma
11. Which of the following assays is recommended as a screening test for colorectal cancer in
persons over 50 years of age?
A. Fecal typsin
B. AFP
C. BTA
D. Occult blood t test - ANSWER-D. Occult blood test
12. Which of the following must be determined to calculate diagnostic specificity?
A. True-negatives and false-positives
, B. True-positives and false-positives
C. True-positives and false-negatives
D. True-negatives and false-negatives - ANSWER-A. True-negatives and false-positives
13. A new tumor marker assay for prostate specific antigen (PSA) is evaluated for sensitivity by
testing serum samples from patients who have been diagnosed as having prostate cancer. The
following results were obtained:
Number of prostate cancer patients who tested positive by the new assay = 42 out 46
Number of patients who did not have cancer and tested negative by the new assay = 31 out of
32
What is the sensitivity of the new assay for PSA?
A. 98.0%
B. 95.0%
C. 91.3%
D. 88.5% - ANSWER-C. 91.3%
14. Which statement below best describes the molecular difference between free PSA (fPSA)
and complex PSA (cPSA)?
A. Free PSA is bound by compounds such as ACT, PCI, API, or AMG
B. Free PSA is an active form that can complex with protease inhibitors
C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
D. Free PSA cannot be detected in serum, whereas complex PSA can - ANSWER-C. Free PSA is
not bound by compounds such as ACT, PCI, API, or AMG
15. The production of alpha fetal protein (AFP) in a healthy individual is best reflected by which
of the following statements?
A. The production of AFP remains the same through life
B. The production of AFP declines rapidly at birth and healthy adults and children have
negligible or undetectable levels in serum
EXAM QUESTIONS AND CORRECT DETAILED
ANSWERS A NEW UPDATED VERSION LATEST
2025(VERIFIED ANSWERS) ALREADY GRADED A+
1. In which of the following disorders would the maternal serum level of 1-fetoprotein be
elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma - ANSWER-A. Neural tube defect
2. Which of the following is FALSE about PSA?
A. It is a single-chain glycoprotein
B. It is used as a tumor marker
C. It is not elevated in benign prostatic hyperplasia
D. It is quantified in serum by immunoassays - ANSWER-C. It is not elevated in benign prostatic
hyperplasia.
3. Which of the following biomarkers is elevated in nonmucinous epithelial ovarian cancer?
A. CA 15-3
B. CA 19-9
C. CA 125
D. CEA - ANSWER-C. CA 125
,4. Which of the following is a sialylated Lewis blood group antigen associated with colorectal
cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - ANSWER-D. CA 19-9
5. Which of the following biomarkers are elevated in advanced stages of breast cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
D. DUPAN-2 and Gastrin - ANSWER-C. CA 15-3 and CA 549
6. Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
D. Nuclear matrix protein - ANSWER-D. Nuclear matrix protein
7. What is the primary clinical usefulness of measuring carcinoembryonic antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - ANSWER-D. Monitoring for recurrence of colon
cancer
8. Which of the following is used to assess the usefulness of trastuzumab (Herceptin®) therapy
for breast cancer?
,A. CA 15-3
B. HER-2/neu
C. CA 125
D. Prolactin - ANSWER-B. HER-2/neu
9. Which type of HCG test would be most useful to assess a person suspected of having
testicular cancer?
A. Plasma immunoassay for intact HCG and the β-HCG subunits
B. Plasma immunoassay from the free alpha and β-HCG subunits
C. Urine assay for HCG-β core
D. Plasma immunoassay for intact HCG only - ANSWER-A. Plasma immunoassay for intact HCG
and the β-HCG subunits
10. A markedly elevated serum AFP is associated with which of the following?
A. Ovarian cancer
B. Lung cancer
C. Hepatoma
D. Breast cancer - ANSWER-C. Hepatoma
11. Which of the following assays is recommended as a screening test for colorectal cancer in
persons over 50 years of age?
A. Fecal typsin
B. AFP
C. BTA
D. Occult blood t test - ANSWER-D. Occult blood test
12. Which of the following must be determined to calculate diagnostic specificity?
A. True-negatives and false-positives
, B. True-positives and false-positives
C. True-positives and false-negatives
D. True-negatives and false-negatives - ANSWER-A. True-negatives and false-positives
13. A new tumor marker assay for prostate specific antigen (PSA) is evaluated for sensitivity by
testing serum samples from patients who have been diagnosed as having prostate cancer. The
following results were obtained:
Number of prostate cancer patients who tested positive by the new assay = 42 out 46
Number of patients who did not have cancer and tested negative by the new assay = 31 out of
32
What is the sensitivity of the new assay for PSA?
A. 98.0%
B. 95.0%
C. 91.3%
D. 88.5% - ANSWER-C. 91.3%
14. Which statement below best describes the molecular difference between free PSA (fPSA)
and complex PSA (cPSA)?
A. Free PSA is bound by compounds such as ACT, PCI, API, or AMG
B. Free PSA is an active form that can complex with protease inhibitors
C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
D. Free PSA cannot be detected in serum, whereas complex PSA can - ANSWER-C. Free PSA is
not bound by compounds such as ACT, PCI, API, or AMG
15. The production of alpha fetal protein (AFP) in a healthy individual is best reflected by which
of the following statements?
A. The production of AFP remains the same through life
B. The production of AFP declines rapidly at birth and healthy adults and children have
negligible or undetectable levels in serum
