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MCB5252 Exam 2 Study Guide.
Innate immune cells include... - Answers✔Macrophages, granulocytes, natural killer cells,
dendritic cells
Innate immunity chemical mediators - Answers✔lysozyme
complement
defensins
Acquired immunity cells - Answers✔B and T cells, antigen presenting cells (APC)
Acquired vs innate: which distinguishes self from non-self? - Answers✔Acquired (failure results
in autoimmune disease)
Innate immunity specificity - Answers✔specific for molecules and molecular patterns associated
with pathogens and molecules produced by dead/damaged cells
Adaptive immunity specificity - Answers✔highly specific, discriminates even minor differences
in molecular structure; details of microbial or nonmicrobial structure recognized with high
specificity
Innate immunity: soluble components of blood or tissue fluids - Answers✔many antimicrobial
peptides and proteins
Adaptive immunity: soluble components of blood or tissue fluids - Answers✔antibodies
Sebum - Answers✔produced by skin cells; keeps the skin oily; involved in innate immunity
along with low pH
Innate immunity in small intestine - Answers✔bile salt
lactoferrin and transferrin - Answers✔By binding iron, an essential nutrient for bacteria, these
proteins limit bacterial growth.
Sequester iron in the liver and remove it from circulation (which makes you tired because
hemoglobin is less available)
Skin-associated lymphoid tissue (SALT) - Answers✔
1
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Gut-associated lymphoid tissue (GALT) - Answers✔GALT includes Peyer's patches in the gut
and the diffuse lymphatic tissue in the gastrointestinal tract and respiratory system
bronchial-associated lymphoid tissue (BALT) - Answers✔These neoplasms fall under the
broader umbrella of mucosa associated lymphoid tissue (MALT) lymphomas. It is sometimes
considered a type of primary pulmonary lymphoma.
Urogenital system MALT - Answers✔a diffuse system of small concentrations of lymphoid
tissue found in various sites of the body, such as the gastrointestinal tract, thyroid, breast, lung,
salivary glands, eye, and skin.
primary lymphoid organs - Answers✔bone marrow and thymus
secondary lymphoid organs - Answers✔lymph nodes, spleen, tonsils
Monocytes, macrophages, and neutrophils are... - Answers✔phagocytic
macrophages are also antigen presenting cells
Dendritic cells - Answers✔present in small numbers in blood, skin, and mucous membranes of
the nose, lungs, and intestines
contact and process antigens, then display on their surface for antigen presentation
True/False: Dendritic cells come from both the myeloid and lymphoid stem cell lines -
Answers✔True
Macrophages - Answers✔long life
reside in different parts of the body - kidney, liver, lung, under the skin, etc
phagocytic
antigen-presenting
produce cytokines
Macrophages bind directly to pathogen without any other processing which makes it quicker not
to have to wait for communication from other cells. How do they do this? (6 receptors) -
Answers✔1. LPS receptors - recognize bacterial LPS
2. Toll-Like Receptors - recognize pathogen surface molecules - cell wall, membrane, teichoic
acid
3. Mannose receptors - recognize mannose on bacterial surface
4. Scavenger receptors - look for any sign of bacteria - directly attach
2
MCB5252 Exam 2 Study Guide.
Innate immune cells include... - Answers✔Macrophages, granulocytes, natural killer cells,
dendritic cells
Innate immunity chemical mediators - Answers✔lysozyme
complement
defensins
Acquired immunity cells - Answers✔B and T cells, antigen presenting cells (APC)
Acquired vs innate: which distinguishes self from non-self? - Answers✔Acquired (failure results
in autoimmune disease)
Innate immunity specificity - Answers✔specific for molecules and molecular patterns associated
with pathogens and molecules produced by dead/damaged cells
Adaptive immunity specificity - Answers✔highly specific, discriminates even minor differences
in molecular structure; details of microbial or nonmicrobial structure recognized with high
specificity
Innate immunity: soluble components of blood or tissue fluids - Answers✔many antimicrobial
peptides and proteins
Adaptive immunity: soluble components of blood or tissue fluids - Answers✔antibodies
Sebum - Answers✔produced by skin cells; keeps the skin oily; involved in innate immunity
along with low pH
Innate immunity in small intestine - Answers✔bile salt
lactoferrin and transferrin - Answers✔By binding iron, an essential nutrient for bacteria, these
proteins limit bacterial growth.
Sequester iron in the liver and remove it from circulation (which makes you tired because
hemoglobin is less available)
Skin-associated lymphoid tissue (SALT) - Answers✔
1
, ©FYNDLAY
Gut-associated lymphoid tissue (GALT) - Answers✔GALT includes Peyer's patches in the gut
and the diffuse lymphatic tissue in the gastrointestinal tract and respiratory system
bronchial-associated lymphoid tissue (BALT) - Answers✔These neoplasms fall under the
broader umbrella of mucosa associated lymphoid tissue (MALT) lymphomas. It is sometimes
considered a type of primary pulmonary lymphoma.
Urogenital system MALT - Answers✔a diffuse system of small concentrations of lymphoid
tissue found in various sites of the body, such as the gastrointestinal tract, thyroid, breast, lung,
salivary glands, eye, and skin.
primary lymphoid organs - Answers✔bone marrow and thymus
secondary lymphoid organs - Answers✔lymph nodes, spleen, tonsils
Monocytes, macrophages, and neutrophils are... - Answers✔phagocytic
macrophages are also antigen presenting cells
Dendritic cells - Answers✔present in small numbers in blood, skin, and mucous membranes of
the nose, lungs, and intestines
contact and process antigens, then display on their surface for antigen presentation
True/False: Dendritic cells come from both the myeloid and lymphoid stem cell lines -
Answers✔True
Macrophages - Answers✔long life
reside in different parts of the body - kidney, liver, lung, under the skin, etc
phagocytic
antigen-presenting
produce cytokines
Macrophages bind directly to pathogen without any other processing which makes it quicker not
to have to wait for communication from other cells. How do they do this? (6 receptors) -
Answers✔1. LPS receptors - recognize bacterial LPS
2. Toll-Like Receptors - recognize pathogen surface molecules - cell wall, membrane, teichoic
acid
3. Mannose receptors - recognize mannose on bacterial surface
4. Scavenger receptors - look for any sign of bacteria - directly attach
2
