NR 565 PHARMACOLOGY WEEK 1
Pharmacokineticspo-poans--
Thepostudypoofpodrugpoabsorption,podistribution,pometabolism,poandpoexcretionpoinpothepo
body
"Whatpothepobodypodoespotopothepodrug"
Factorspothatpoaffectpodrugpoabsorptionpo(5)po-poans--Ratepoofpodissolution
Surfacepoarea
Bloodpoflow
Lipidposolubility
PHpopartitioning
Factorspothatpoaffectpodrugpodistributionpo(4)po-poans--Bloodpoflowpotopotissues
Abilitypotopoexitpovascularposystem
Blood-brainpobarrier
Protein-bindingpocapacity
Pharmacodynamicspo-poans--
Thepostudypoofpobiochemicalpoandpophysiologicpoeffectspoofpodrugspoonpothepobodypoandp
othepomolecularpomechanismspobypowhichpothosepoeffectspoarepoproduced
"Whatpothepobodypodoespotopothepodrug"
Phamacodynamics:po3pomechanismspoofpoactionpo-poans--Receptor
Enzyme
Non-selectivepointeractionspo(i.e.pochemo)
Typespoofpodrugpotherapypo(7)po-poans--Acute
Maintenancepo(HTN/bc)
Supplementalpo(insulin)
Palliative
Supportivepo(IVpofluid)
Prophylactic
Empiricalpo(broad-spectrumpoabx)
IdiosyncraticpoEffectpo-poans--Unexpectedporesponsepotopomedication
Tolerancepo-poans--Decliningporesponsepotopoapodrug
, Dependencepo-poans--Physiological/
psychologicalponeedpoforpoapodrug;poneedspodrugpoforponormalpofunction
Addictionpo-poans--Compulsivepousepoofpoapodrugpodespiteponegative/dangerouspoeffects
Drugpointeractions:podrug-drugpo-poans--
Whenpo2podrugspocompetepoforpometabolizingpoenzymes
Drugpointeractions:pofood-drugpo-poans--Grapefruitpojuicepoorpoleafypogreens
Drugpointeractions:poadditivepo-poans--1+1po=po2;pobothpoprovidepointendedpoeffect
Drugpointeractions:poantagonisticpo-poans--
1+1po=po<2;polesspothanpodesiredpoeffectpoofpoonepoorpobothpodrugs
Drugpointeractions:posynergisticpo-poans--
1+1po=po>2;posumpototalpoeffectpoispogreaterpothanpoifpogivenpoalonepo(i.e.polisinoprilpo+poH
CTZ)
Drugpointeractions:poincompatibilitypo-poans--
1+1podoesponotpoequalpo2;potwopoIVpodrugspogivenpotogetherpocausingpodecompositionpoo
fpoonepoorpobothpodrugs
8porightspoofpomedicationpoadministrationpo-poans--Patient
Medication
Dose
Route
Time
Reason
Responsepo
Documentation
Adverseporeactions:popharmacologicpo-poans--Extensionpoofpoapodrug'sponormalpoeffect
Adverseporeactions:poAllergic/hypersensitivitypo-poans--
Exaggeratedpoimmuneporesponsepo(i.e.pomildpoitchingpotopoanaphylaxis)
Adverseporeactions:poidiosyncraticpo-poans--Peculiarpotopothepopatient
Adverseporeactions:podrugporeactionpo-poans--Mostpocomplex,podifficultpotopodetermine
Teratogenicpoeffectspo-poans--Causespobirthpodefects
Mutagenicpoeffectspo-poans--Ablepotopocausepochangespoinpogeneticpotissue
Carcinogenpo-poans--Substancespothatpocanpocausepocancer
Pharmacokineticspo-poans--
Thepostudypoofpodrugpoabsorption,podistribution,pometabolism,poandpoexcretionpoinpothepo
body
"Whatpothepobodypodoespotopothepodrug"
Factorspothatpoaffectpodrugpoabsorptionpo(5)po-poans--Ratepoofpodissolution
Surfacepoarea
Bloodpoflow
Lipidposolubility
PHpopartitioning
Factorspothatpoaffectpodrugpodistributionpo(4)po-poans--Bloodpoflowpotopotissues
Abilitypotopoexitpovascularposystem
Blood-brainpobarrier
Protein-bindingpocapacity
Pharmacodynamicspo-poans--
Thepostudypoofpobiochemicalpoandpophysiologicpoeffectspoofpodrugspoonpothepobodypoandp
othepomolecularpomechanismspobypowhichpothosepoeffectspoarepoproduced
"Whatpothepobodypodoespotopothepodrug"
Phamacodynamics:po3pomechanismspoofpoactionpo-poans--Receptor
Enzyme
Non-selectivepointeractionspo(i.e.pochemo)
Typespoofpodrugpotherapypo(7)po-poans--Acute
Maintenancepo(HTN/bc)
Supplementalpo(insulin)
Palliative
Supportivepo(IVpofluid)
Prophylactic
Empiricalpo(broad-spectrumpoabx)
IdiosyncraticpoEffectpo-poans--Unexpectedporesponsepotopomedication
Tolerancepo-poans--Decliningporesponsepotopoapodrug
, Dependencepo-poans--Physiological/
psychologicalponeedpoforpoapodrug;poneedspodrugpoforponormalpofunction
Addictionpo-poans--Compulsivepousepoofpoapodrugpodespiteponegative/dangerouspoeffects
Drugpointeractions:podrug-drugpo-poans--
Whenpo2podrugspocompetepoforpometabolizingpoenzymes
Drugpointeractions:pofood-drugpo-poans--Grapefruitpojuicepoorpoleafypogreens
Drugpointeractions:poadditivepo-poans--1+1po=po2;pobothpoprovidepointendedpoeffect
Drugpointeractions:poantagonisticpo-poans--
1+1po=po<2;polesspothanpodesiredpoeffectpoofpoonepoorpobothpodrugs
Drugpointeractions:posynergisticpo-poans--
1+1po=po>2;posumpototalpoeffectpoispogreaterpothanpoifpogivenpoalonepo(i.e.polisinoprilpo+poH
CTZ)
Drugpointeractions:poincompatibilitypo-poans--
1+1podoesponotpoequalpo2;potwopoIVpodrugspogivenpotogetherpocausingpodecompositionpoo
fpoonepoorpobothpodrugs
8porightspoofpomedicationpoadministrationpo-poans--Patient
Medication
Dose
Route
Time
Reason
Responsepo
Documentation
Adverseporeactions:popharmacologicpo-poans--Extensionpoofpoapodrug'sponormalpoeffect
Adverseporeactions:poAllergic/hypersensitivitypo-poans--
Exaggeratedpoimmuneporesponsepo(i.e.pomildpoitchingpotopoanaphylaxis)
Adverseporeactions:poidiosyncraticpo-poans--Peculiarpotopothepopatient
Adverseporeactions:podrugporeactionpo-poans--Mostpocomplex,podifficultpotopodetermine
Teratogenicpoeffectspo-poans--Causespobirthpodefects
Mutagenicpoeffectspo-poans--Ablepotopocausepochangespoinpogeneticpotissue
Carcinogenpo-poans--Substancespothatpocanpocausepocancer
