WGUlD441l(NewlUpdate)lMedicallDosagel
CalculationslandlPharmacology |Qsl&lAs|l
100%lCorrect|lGradelAl(VerifiedlAnswers)
QUESTION
Whichlpieceloflobjectiveldatalcontraindicatesltheluseloflclozapine?
1.lAllergyltolphenothiazines
2.lSelf-destructivelbehavior
3.lFailedlantipsychoticltherapy
4.lAcutellymphocyticlleukemia
Answer:
4.lClozapinelislcontraindicatedlinlpatientslwithlalhistoryloflmyeloproliferativeldisorderslsuchlas
lleukemialbecauselthislmedicationlcanlcauselfatallagranulocytosis.lForlthislreason,lweeklylmoni
toringloflthelwhitelbloodlcelll(WBC)lcountlislmandatory.lIfltheltotallWBClcountlfallslbelowl30
00/mm3,ltreatmentlshouldlbelinterrupted.lBecauselclozapinelislnotlalphenothiazine,lanlallergylt
olthoselmedicationslposeslnolobstacleltolitsluse.lClozapinelislindicatedlforlpatientslwithlalhighlr
isklforlsuicidelandlfailedlantipsychoticltherapylinvolvingltheluseloflotherlmedications.
QUESTION
Whichllaboratoryltestlshouldlbelmonitoredlfrequentlyltolassesslforlalpotentialllife-
threateningladverselreactionltolclozapine?
1.lRenallpanel
2.lLiverlfunctionltests
3.lCompletelbloodlcount
4.lImmunoglobulinllevels
Answer:
3.lPatientsltakinglclozapinelmustlbelmonitoredlforlthellife-
threateninglsideleffectloflagranulocytosis,levidencedlbylalseverelreductionlinlthelnumberloflwhi
telbloodlcells.lRenallpanels,lliverlfunctionltests,landlimmunoglobulinllevelslarelnotlfactors.
,QUESTION
Whatlislthelmainlreceptorlinlthelcentrallnervouslsysteml(CNS)lthatlislblockedlbylconventionalla
ntipsychoticldrugs?
1.lSerotonin
2.lDopamine
3.lAcetylcholine
4.lNorepinephrine
Answer:
2.lConventionallantipsychoticlagentslblockldopaminelreceptors,lprimarilylinlthelCNS.lThelbloc
kadelofldopaminelreceptorslislresponsiblelforltheltherapeuticlandltoxicleffectslofltheselmedicati
ons.lAtypicallantipsychoticlagentslblockldopamine2lreceptorslandlserotoninlreceptors,lofferingli
mprovedltherapeuticleffectivenesslandlalmorelfavorablelsideleffectlprofile.lSerotonin,lacetylcho
line,landlnorepinephrinelarelnotlblockedlbylconventionallantipsychoticldrugs.
QUESTION
Thelnurselislcaringlforlalpatientlwholhaslbipolarldisorderlwholhaslbeenladministeredllithiumlcit
rate.lThelprimarylhealthlcarelproviderlaskslthelnurseltolconstantlylmonitorlthelpatient'slbloodlso
diumllevels.lWhatlislthelreasonlforlgivinglsuchlanlinstruction?
1.lTolensurelproperlnourishmentlinlthelpatient
2.lTolpreventlrenalltoxicitylcausedlbyltheldrug
3.lTolmaintainltherapeuticlconcentrationlofllithium
4.lTolmaintainlnormallcholesterolllevelslinlthelbody
Answer:
3.lBecauselbothllithiumlandlsodiumlarelmonovalentlions,lthelserumllithiumlconcentrationlislalte
redlwithlchangeslinlthelsodiumlconcentration.lThereforelinlorderltolmaintainlalconstantltherape
uticllevel,lalnormallconcentrationloflsodiumlislrequiredlinlthelbody.lSodiumllevelslaloneldolnotl
ensurelthatlthelpatientlhaslproperlnourishment.lRegularlylmonitoringlsodiumllevelslwilllnotlhel
plinlreducinglthelrenalltoxicitylcausedlbylthelmedication.lThelnurselshouldlchecklthelpatient'slu
rineloutputlandlensurelproperlfluidlintakeltolpreventlrenalltoxicity.lSodiumllevelsldolnotlaffectlc
holesterolllevelslinlthelblood.
QUESTION
,Thelnurselislcaringlforlalpatientlwithlacutelmanialwholhaslbeenlprescribedllithiumlcarbonate.lT
helbloodltestsloflthelpatientlindicatelthelserumllithiumllevelltolbel1.2lmEq/L.lWhatldoeslthelnur
selinterpretlfromlthislresult?
1.lThelpatientlwilllhavelpersistentlmaniclsymptoms.
2.lThelpatientlmaylhavelcardiacldysrhythmialandltremors.
3.lThelpatientlmaylhavelimpairedlliverlandlrenallfunctioning.
4.lThelpatientlshouldlhaveleffectivelrelieflfromlthelmaniclsymptoms.
Answer:
4.lTherelislalnarrowltherapeuticlwindowlbetweenltheltherapeuticlandltoxiclserumllevelslofllithi
um.lAlserumllithiumllevellofl1ltol1.5lmEq/Llisloptimumlforltheltreatmentloflacutelmania.lTher
eforelalserumllithiumllevellofl1.2lmEq/Llindicateslthatlthelpatientlwilllhaveleffectivelrelieflfro
mlthelmaniclsymptoms.lIflthelserumllithiumllevellisllesslthanl1lmEq/L,lthenlthelpatientlmaylha
velpersistentlmaniclsymptoms.lTheladverseleffectslofllithiumltoxicitylincludelcardiacldysrhyth
mialandltremors.lIflthellithiumlserumllevellislmorelthanl1.5lmEq/L,lthenlthelpatientlmaylhavelli
thiumltoxicity,lwhichlislcharacterizedlbylimpairedlliverlandlrenallfunctioning.
QUESTION
Alpatientlwithlalhistoryloflabusinglopioidlanalgesicslneedslanlantianxietylagent.lWhichlmedicat
ionlshouldlthelnurselexpectltoladminister?
1.lDiazepam
2.lBuspirone
3.lVenlafaxine
4.lEscitalopram
Answer:
2.lBecauselthelpotentiallforlabuselisllow,lbuspironelislalsuitablelantianxietylagentlforlthislpatien
t.lDiazepamlislcontraindicatedlbecauselbenzodiazepineslarelhighlyladdictive.lVenlafaxinelislalse
rotonin-
norepinephrinelreuptakelinhibitor,landlescitalopramlislalselectivelserotoninlreuptakelinhibitor;lb
othlmedicationslhavelallowlpotentiallforlabuselandlarelfirst-
linelantidepressantltherapies.lThelnurseldoeslnotlknowlwhetherlthelpatientlhasldepressionlalong
lwithlthelanxiety,lsoltheseldrugslarelnotlindicated.
QUESTION
, Whichlarelcommonlsymptomsloflserotoninlsyndrome?lSelectlalllthatlapply.
1.lDelirium
2.lMyoclonus
3.lDrowsiness
4.lCoarseltremors
5.lSuicidallthoughts
Answer:
1,l2,l4
Serotoninlsyndromelislalconditionlthatloccurslbecauseloflanladverseleffectloflanyldruglorlbecau
selalcombinationlofldrugslhavelserotoninergiclactivity.lThelsymptomsloflserotoninlsyndromelin
cludeldelirium,lmyoclonusl(musclelspasms),lcoarseltremors,lagitation,lsweating,landltachycardi
a.lDrowsinesslislanlabnormallfeelinglthatloccurslaslalsideleffectloflsedatives,lhypnotics,landlmo
odlstabilizers,lbutlislnotlalsymptomloflserotoninlsyndrome.lSuicidallthoughtslarelobservedlinlpa
tientslwholhavelsevereldepression.
QUESTION
Thelnurselislcaringlforlalpatientlwholunderwentlalprocedurelthatlinvolvedltheluselofllidocaine.l
Howllonglshouldlthelnurselexpectlthelactionloflthellidocaineltollast?
1.l30ltol60lminutes
2.l60ltol90lminutes
3.l90ltol120lminutes
4.l120ltol150lminutes
Answer:
2.lLidocainelislalparenteralllocallanestheticldrug.lTheldurationloflactionlofllidocainelisl60ltol90l
minutes.lTheldurationloflactionloflprocainelisl30ltol60lminutes.lTheldurationloflactionlofltetrac
ainelisl90ltol120lminutes,landltheldurationloflactionloflmepivacainelisl120ltol150lmin.
QUESTION
Whichlpostoperativelnursinglactionlwilllhelplthelpatientlrecoverlfromltheleffectsloflanesthesia?
1.lAmbulatingloncelalday
2.lForcinglfluidsltol400lmLlperlshift
3.lAdministeringlloperamidelaslneeded
4.lTurning,lcoughing,landldeeplbreathingleveryl2lhours
CalculationslandlPharmacology |Qsl&lAs|l
100%lCorrect|lGradelAl(VerifiedlAnswers)
QUESTION
Whichlpieceloflobjectiveldatalcontraindicatesltheluseloflclozapine?
1.lAllergyltolphenothiazines
2.lSelf-destructivelbehavior
3.lFailedlantipsychoticltherapy
4.lAcutellymphocyticlleukemia
Answer:
4.lClozapinelislcontraindicatedlinlpatientslwithlalhistoryloflmyeloproliferativeldisorderslsuchlas
lleukemialbecauselthislmedicationlcanlcauselfatallagranulocytosis.lForlthislreason,lweeklylmoni
toringloflthelwhitelbloodlcelll(WBC)lcountlislmandatory.lIfltheltotallWBClcountlfallslbelowl30
00/mm3,ltreatmentlshouldlbelinterrupted.lBecauselclozapinelislnotlalphenothiazine,lanlallergylt
olthoselmedicationslposeslnolobstacleltolitsluse.lClozapinelislindicatedlforlpatientslwithlalhighlr
isklforlsuicidelandlfailedlantipsychoticltherapylinvolvingltheluseloflotherlmedications.
QUESTION
Whichllaboratoryltestlshouldlbelmonitoredlfrequentlyltolassesslforlalpotentialllife-
threateningladverselreactionltolclozapine?
1.lRenallpanel
2.lLiverlfunctionltests
3.lCompletelbloodlcount
4.lImmunoglobulinllevels
Answer:
3.lPatientsltakinglclozapinelmustlbelmonitoredlforlthellife-
threateninglsideleffectloflagranulocytosis,levidencedlbylalseverelreductionlinlthelnumberloflwhi
telbloodlcells.lRenallpanels,lliverlfunctionltests,landlimmunoglobulinllevelslarelnotlfactors.
,QUESTION
Whatlislthelmainlreceptorlinlthelcentrallnervouslsysteml(CNS)lthatlislblockedlbylconventionalla
ntipsychoticldrugs?
1.lSerotonin
2.lDopamine
3.lAcetylcholine
4.lNorepinephrine
Answer:
2.lConventionallantipsychoticlagentslblockldopaminelreceptors,lprimarilylinlthelCNS.lThelbloc
kadelofldopaminelreceptorslislresponsiblelforltheltherapeuticlandltoxicleffectslofltheselmedicati
ons.lAtypicallantipsychoticlagentslblockldopamine2lreceptorslandlserotoninlreceptors,lofferingli
mprovedltherapeuticleffectivenesslandlalmorelfavorablelsideleffectlprofile.lSerotonin,lacetylcho
line,landlnorepinephrinelarelnotlblockedlbylconventionallantipsychoticldrugs.
QUESTION
Thelnurselislcaringlforlalpatientlwholhaslbipolarldisorderlwholhaslbeenladministeredllithiumlcit
rate.lThelprimarylhealthlcarelproviderlaskslthelnurseltolconstantlylmonitorlthelpatient'slbloodlso
diumllevels.lWhatlislthelreasonlforlgivinglsuchlanlinstruction?
1.lTolensurelproperlnourishmentlinlthelpatient
2.lTolpreventlrenalltoxicitylcausedlbyltheldrug
3.lTolmaintainltherapeuticlconcentrationlofllithium
4.lTolmaintainlnormallcholesterolllevelslinlthelbody
Answer:
3.lBecauselbothllithiumlandlsodiumlarelmonovalentlions,lthelserumllithiumlconcentrationlislalte
redlwithlchangeslinlthelsodiumlconcentration.lThereforelinlorderltolmaintainlalconstantltherape
uticllevel,lalnormallconcentrationloflsodiumlislrequiredlinlthelbody.lSodiumllevelslaloneldolnotl
ensurelthatlthelpatientlhaslproperlnourishment.lRegularlylmonitoringlsodiumllevelslwilllnotlhel
plinlreducinglthelrenalltoxicitylcausedlbylthelmedication.lThelnurselshouldlchecklthelpatient'slu
rineloutputlandlensurelproperlfluidlintakeltolpreventlrenalltoxicity.lSodiumllevelsldolnotlaffectlc
holesterolllevelslinlthelblood.
QUESTION
,Thelnurselislcaringlforlalpatientlwithlacutelmanialwholhaslbeenlprescribedllithiumlcarbonate.lT
helbloodltestsloflthelpatientlindicatelthelserumllithiumllevelltolbel1.2lmEq/L.lWhatldoeslthelnur
selinterpretlfromlthislresult?
1.lThelpatientlwilllhavelpersistentlmaniclsymptoms.
2.lThelpatientlmaylhavelcardiacldysrhythmialandltremors.
3.lThelpatientlmaylhavelimpairedlliverlandlrenallfunctioning.
4.lThelpatientlshouldlhaveleffectivelrelieflfromlthelmaniclsymptoms.
Answer:
4.lTherelislalnarrowltherapeuticlwindowlbetweenltheltherapeuticlandltoxiclserumllevelslofllithi
um.lAlserumllithiumllevellofl1ltol1.5lmEq/Llisloptimumlforltheltreatmentloflacutelmania.lTher
eforelalserumllithiumllevellofl1.2lmEq/Llindicateslthatlthelpatientlwilllhaveleffectivelrelieflfro
mlthelmaniclsymptoms.lIflthelserumllithiumllevellisllesslthanl1lmEq/L,lthenlthelpatientlmaylha
velpersistentlmaniclsymptoms.lTheladverseleffectslofllithiumltoxicitylincludelcardiacldysrhyth
mialandltremors.lIflthellithiumlserumllevellislmorelthanl1.5lmEq/L,lthenlthelpatientlmaylhavelli
thiumltoxicity,lwhichlislcharacterizedlbylimpairedlliverlandlrenallfunctioning.
QUESTION
Alpatientlwithlalhistoryloflabusinglopioidlanalgesicslneedslanlantianxietylagent.lWhichlmedicat
ionlshouldlthelnurselexpectltoladminister?
1.lDiazepam
2.lBuspirone
3.lVenlafaxine
4.lEscitalopram
Answer:
2.lBecauselthelpotentiallforlabuselisllow,lbuspironelislalsuitablelantianxietylagentlforlthislpatien
t.lDiazepamlislcontraindicatedlbecauselbenzodiazepineslarelhighlyladdictive.lVenlafaxinelislalse
rotonin-
norepinephrinelreuptakelinhibitor,landlescitalopramlislalselectivelserotoninlreuptakelinhibitor;lb
othlmedicationslhavelallowlpotentiallforlabuselandlarelfirst-
linelantidepressantltherapies.lThelnurseldoeslnotlknowlwhetherlthelpatientlhasldepressionlalong
lwithlthelanxiety,lsoltheseldrugslarelnotlindicated.
QUESTION
, Whichlarelcommonlsymptomsloflserotoninlsyndrome?lSelectlalllthatlapply.
1.lDelirium
2.lMyoclonus
3.lDrowsiness
4.lCoarseltremors
5.lSuicidallthoughts
Answer:
1,l2,l4
Serotoninlsyndromelislalconditionlthatloccurslbecauseloflanladverseleffectloflanyldruglorlbecau
selalcombinationlofldrugslhavelserotoninergiclactivity.lThelsymptomsloflserotoninlsyndromelin
cludeldelirium,lmyoclonusl(musclelspasms),lcoarseltremors,lagitation,lsweating,landltachycardi
a.lDrowsinesslislanlabnormallfeelinglthatloccurslaslalsideleffectloflsedatives,lhypnotics,landlmo
odlstabilizers,lbutlislnotlalsymptomloflserotoninlsyndrome.lSuicidallthoughtslarelobservedlinlpa
tientslwholhavelsevereldepression.
QUESTION
Thelnurselislcaringlforlalpatientlwholunderwentlalprocedurelthatlinvolvedltheluselofllidocaine.l
Howllonglshouldlthelnurselexpectlthelactionloflthellidocaineltollast?
1.l30ltol60lminutes
2.l60ltol90lminutes
3.l90ltol120lminutes
4.l120ltol150lminutes
Answer:
2.lLidocainelislalparenteralllocallanestheticldrug.lTheldurationloflactionlofllidocainelisl60ltol90l
minutes.lTheldurationloflactionloflprocainelisl30ltol60lminutes.lTheldurationloflactionlofltetrac
ainelisl90ltol120lminutes,landltheldurationloflactionloflmepivacainelisl120ltol150lmin.
QUESTION
Whichlpostoperativelnursinglactionlwilllhelplthelpatientlrecoverlfromltheleffectsloflanesthesia?
1.lAmbulatingloncelalday
2.lForcinglfluidsltol400lmLlperlshift
3.lAdministeringlloperamidelaslneeded
4.lTurning,lcoughing,landldeeplbreathingleveryl2lhours
