GMS 6510 Exam 2 questions with verified answers A+ rated

GMS 6510 Exam 2 questions with
verified answers A+ rated

What type of receptor is the nAChR?



Voltage-gates ion channel

GPCR

Receptor tyrosine kinase

Ligand-gated ion channel

Hormone receptor - correct answer ✔✔ligand-gated ion channel



Which nAChR subunit binds nicotine?

α

β

γ

δ

ε - correct answer ✔✔alpha



To which nAChR state does nicotine bind with the greatest affinity?



Closed/active

Open/Active

Desensitized - correct answer ✔✔Desensitized



Through which route of administration are maximal plasma nicotine concentrations obtained the
fastest?



Cigarette

, Snuff

Chewing - correct answer ✔✔Cigarette



Through which route of administration are maximal plasma nicotine concentrations maintained for the
shortest time?



Chewing

Snuff

Cigarette - correct answer ✔✔Cigarette



True or false? Smoking the same number of low-nicotine cigarettes as standard cigarettes results in lower
nicotine concentrations in the blood.



True

False - correct answer ✔✔True



Nicotine is primarily metabolized by which enzyme?



SULT1A1

CYP2D3

UGT1A1

SULT1E2

CYP2A6 - correct answer ✔✔CYP2A6



According to the Fagerström test, smoking at what part of the day is most associated with dependence?



Morning

Afternoon

Evening - correct answer ✔✔Morning