GMS 6121 Exam 1 Module 1.2 questions with complete solutions

GMS 6121 Exam 1 Module 1.2 questions
with complete solutions

What does virus replication strategy depend on? - correct answer ✔✔The form of the incoming genome



ds vs ss

RNA vs DNA

+ vs - strand

reverse transcriptase present



Describe ds dNA virus replication - correct answer ✔✔identical to host

transcribed directly from incoming viral genome to mRNA

new mRNA provides critical factors for replication of dsDNA, these early genes go back and help with
replication

ex. Herpes and pox viruses



Describe ssDNA virus replication - correct answer ✔✔ssDNA has to have antisense copy

host cell polymerase makes it

from both copies, very similar to dsDNA replication

ex. parvovirus



Describe (+)ssRNA virus replication - correct answer ✔✔+RNA basically the same as mRNA = sense
strand



can be immediately translated into proteins



RNA dependent RNA poly is made

(RDRP)

, binds incoming genome strands

make antisense copy



antisense template for sense strand, many copies



some translated into proteins



capsid made, + RNA inserted



ex. Hep C, polio, SARS



Describe (-)ssRNA virus replication - correct answer ✔✔cant be translated into protein



bring their own RDRP to make + strand that acts as mRNA



now able to amplify



can make sense strand RNA which serves as template for antisense strand



proteins being generated from sense strand as well, capsid made



Describe dsRNA virus replication - correct answer ✔✔segmented virus



Rio virus has 10 different RNA segments



carries with it all proteins required for transcription



all 10 segments simultaneously transcribed to mRNA