week 6: coagulation cascade solved questions
secondary hemostasis involves the intrinsic and extrinsic pathways,
which originate separately but lead to a common pathway that ultimately
activates ______________ in order to stabilize the
_____________________ with a _____________ Correct Answer-fibrin
(factor I)
primary hemostatic plug
fibrin mesh
the intrinsic pathway is activated by ____________________ and
consists of what 6 factors? Correct Answer-exposed endothelial collagen
1, 2, 9, 10, 11, and 12 (I, II, IX, X, XI, and XII)
the extrinsic pathway is activated by ____________________ and
consists of what 4 factors? Correct Answer-tissue factor (III), which is
released after external damage
1, 2, 7, 10 (I, II, VII, and X)
what are the actual names of factors I, II, and IIa? Correct Answer-I:
fibrinogen
II: prothrombin
IIa: thrombin
3 stages of primary hemostatic (ptl) plug formation:
,1. Adhesion: mechanical damage exposes subendothelial collagen.
_______ is produced at the damage site. ______ will bind to the
collagen via ______ and ______
2. aggregation: platelets will produce _______________, which acts as a
pheromone to cause _______________________
3. swelling: ________ make platelets express _________ and _______,
which act as binding sites for ____________ cause platelets cohesion
Correct Answer-vWF
platelets
vWF and GPIb
thromboxane a2
platelets to aggregate
ADP
GPIIa and GPIIb
fibrinogen
what 3 things activate platelets? Correct Answer--ADP
-Ca2+
-serotonin
when factor ___ is activated, it can reinforce the __________ pathway
by giving positive feedback to factor ___ (as well as cofactors V, VIII,
, and XIII). this makes factor ____ less critical!!! Correct Answer-II
(prothrombin)
intrinsic
XI
XII
what is the function of factor XIII? Correct Answer-stabilizes the
platelet clot by acting on fibrin strands to form fibrin mesh
the intrinsic pathway is clinically measures as ________ and the
extrinsic pathway is measures as _________ Correct Answer-partial
thromboplastin time (PTT)
partial thrombin time (PT INR)
what anticoagulant acts on the intrinsic pathway vs the extrinsic
pathway? Correct Answer--intrinsic: heparin
-extrinsic: warfarin
the common pathway begins at factor ____ which is activated to factor
_____ by __________ Correct Answer-X --> Xa by tenase
what 5 factors are involved in the common pathway? Correct Answer-1,
2, 5, 8, and 10
(I, II, V, VIII, and X)
secondary hemostasis involves the intrinsic and extrinsic pathways,
which originate separately but lead to a common pathway that ultimately
activates ______________ in order to stabilize the
_____________________ with a _____________ Correct Answer-fibrin
(factor I)
primary hemostatic plug
fibrin mesh
the intrinsic pathway is activated by ____________________ and
consists of what 6 factors? Correct Answer-exposed endothelial collagen
1, 2, 9, 10, 11, and 12 (I, II, IX, X, XI, and XII)
the extrinsic pathway is activated by ____________________ and
consists of what 4 factors? Correct Answer-tissue factor (III), which is
released after external damage
1, 2, 7, 10 (I, II, VII, and X)
what are the actual names of factors I, II, and IIa? Correct Answer-I:
fibrinogen
II: prothrombin
IIa: thrombin
3 stages of primary hemostatic (ptl) plug formation:
,1. Adhesion: mechanical damage exposes subendothelial collagen.
_______ is produced at the damage site. ______ will bind to the
collagen via ______ and ______
2. aggregation: platelets will produce _______________, which acts as a
pheromone to cause _______________________
3. swelling: ________ make platelets express _________ and _______,
which act as binding sites for ____________ cause platelets cohesion
Correct Answer-vWF
platelets
vWF and GPIb
thromboxane a2
platelets to aggregate
ADP
GPIIa and GPIIb
fibrinogen
what 3 things activate platelets? Correct Answer--ADP
-Ca2+
-serotonin
when factor ___ is activated, it can reinforce the __________ pathway
by giving positive feedback to factor ___ (as well as cofactors V, VIII,
, and XIII). this makes factor ____ less critical!!! Correct Answer-II
(prothrombin)
intrinsic
XI
XII
what is the function of factor XIII? Correct Answer-stabilizes the
platelet clot by acting on fibrin strands to form fibrin mesh
the intrinsic pathway is clinically measures as ________ and the
extrinsic pathway is measures as _________ Correct Answer-partial
thromboplastin time (PTT)
partial thrombin time (PT INR)
what anticoagulant acts on the intrinsic pathway vs the extrinsic
pathway? Correct Answer--intrinsic: heparin
-extrinsic: warfarin
the common pathway begins at factor ____ which is activated to factor
_____ by __________ Correct Answer-X --> Xa by tenase
what 5 factors are involved in the common pathway? Correct Answer-1,
2, 5, 8, and 10
(I, II, V, VIII, and X)
