fluid compartments in body - Answers intracellular-inside cell
extracellular-outside cell in 3 compartments
interstitial fluid - Answers fluid in the spaces between cells-third space
intravascular fluid - Answers fluid within blood vessels
plasma
lymph fluid - Answers fluid that circulates through the body in lymph vessels and eventually enters the
bloodstream
insensible water loss - Answers the loss of water not noticeable by a person, such as through
evaporation from the skin and exhalation from the lungs during breathing
normal kidney output - Answers 30 mL/hr
0.5mL/kg/hr
1 liter water - Answers 2.2lbs or 1 kg
blood osmolarity - Answers 275mOsm/kg - 295mOsm/kg
An increase can result from dehydration - think -high and dry
A decrease can result from fluid overload or excessive intravascular fluid - think low - below Below sea
level, therefore wet.
regulators blood osmolarity - Answers Hypothalamus monitors osmotic pressure (ratio of solute
particles to solvent water/fluid) an increase in osmotic pressure leads to thirst
ADH -reabsorbs water from the filtrate (urine) in the kidneys keeping the fluid in the body decreasing
osmotic pressure
Aldosterone-reabsorbs Na+ from the filtrate (urine) keeping the Na+ in the body increasing the osmotic
pressure (remember aldosterone and cortisol are steroids so when a client is on steroids they may retain
Na+ and become hypernatremic) Water follows Na+ so ↑ in Na+ re-absorption in kidneys = ↑ water re-
absorption as well.
isotonic solutions - Answers of the same concentration
5% Glucose
0 .9% NaCl
, LR - Lactated Ringers
hypotonic solutions - Answers of below concentration WATER, 0. 45% NaCl,
hypertonic solutions - Answers of above concentration 50% Glucose, 3% normal saline .
BUN - Answers BUN 10-20 mg/dl Normal
Creatinine 0.6-1.3 mg/dl
Increase in Blood urea nitrogen (BUN) means an increase in protein metabolism which could be due to
crushing injuries, burns, or other traumas. An increase in serum creatinine would reflect a decrease in
kidney function. Urine becomes closer to plasma and the influence of diet will be seen to have a more
direct affect on the urine.
Sodium - Answers + 135 -145 mEq/L
Function: Most abundant extracellular ion. Function in the generation of action potential in skeletal
muscle and nervous tissue. Maintains osmotic pressure of the ECF. Amount of Na+ regulates water
balance and blood pressure. Controlled by ADH, aldosterone, and ANP (atrial naturetic peptide). Foods
high in sodium: processed/canned, broth, vegetable juices, and celery
hyponatremia - Answers Cause: Loss of NA+ through sweat, vomiting, diarrhea, diuretic or burns. True
excess of water as in SIADH or renal failure. Also seen in when cells begin to lyse increasing extracellular
K+. Excess of dextrose IV solutions or fluid replacement with water (ice chips). Symptoms: Weight gain,
muscle weakness, tachycardia but weak pulse & shock. Mental confusion and anxiety due to increase
water in CNS, (Brain cells swell) stupor and coma may result
Hypernatremia - Answers Cause: Increase in Na+ in the ECF due to dehydration or decrease of water
intake. Also Na+ gain in diet, medication or through IV solution. Caused by polyuria such as with
Diabetes mellitus, also seen in burns, and in Cushing disease. Osmotic diuretics and mechanical
ventilation may lead to H2O loss without Na+ loss. Symptoms: Intense thirst, poor skin turgor, overall
weakness, and lethargy. Finally renal failure or coma may result from to cellular dehydration. (Brain cells
shrink)
Potassium - Answers 3.5-5.0 mEq/L
Function: Most abundant intracellular ion needed for the repolarization of action potential in skeletal
muscle and nervous tissue, also maintains osmotic pressure. Helps in the pH balance. Controls blood
pressure through the secretion of aldosterone (Increase of K+ leads to increase of Aldosterone). NOTE:
K+ is not stored by the body; freely excreted by kidneys Foods High in K+: bananas, pears, potatoes, tea,
colas and fruit juices. Never give more than 40MEq of KCl/L Intravenously!
hypokalemia - Answers Cause: Increase of Na+, vomiting, diarrhea, use of some diuretics, IV insulin or
glucose, and kidney disease. Also seen in cases of excessive Aldosterone as in adrenal tumor or Cushing's
disease. Symptoms: Muscular weakness, increased urine output, depressed respirations, vomiting and