and Answers 100% Pass
Hemostasis - ANSWER✔✔-Prevention of blood loss after blood vessel is
damaged. This process is accomplished by a complex interaction with the
vessel wall, circulating platelets, and plasma coagulation proteins. (3 steps)
Primary hemostasis - ANSWER✔✔-The initial response to vascular injury
involving the interaction between platelets and endothelium of injured
vessel.
Describe the process of primary hemostasis - ANSWER✔✔-The injured
vessels vasoconstricts and prevent blood loss. The platelet plug forms
when platelets adhere to endothelial collagen and clump together at the
site of injury.
Secondary hemostasis - ANSWER✔✔-Involves the formation of a fibrin
cloth through intrinsic and extrinsic pathways; coagulation.
Describe the process of secondary hemostasis - ANSWER✔✔-Clotting
factors are activated via the intrinsic and extrinsic pathways that catalyze
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, the conversion of fibrinogen into fibrin. A fibrin clot or coagulation forms
at the site of injury to maintain hemostasis.
Clot retraction stage - ANSWER✔✔-The final stage of clot formation.
Components of a fibrin clot (platelet plug, fibrin strands, and trapped RBC)
are compressed to form a firm clot.
Where are coagulation factors synthesized? - ANSWER✔✔-liver
Coagulation factors - ANSWER✔✔--Factors requiring vitamin K: 2, 7, 9, 10
-extrinsic pathway factors :3, 7
-intrinsic pathway factors: 8, 9, 11, 12
-common pathway factors: 1, 2, 5, 10, 13
Intrinsic pathway of coagulation - ANSWER✔✔-Blood comes in contact
with altered vascular endothelium. Factor XII initiate the pathway.
Extrinsic pathway of coagulation - ANSWER✔✔-Happens when vascular
wall is is injured.Factor III activates this a pathway.
Common final pathway of coagulation - ANSWER✔✔-Initiated by factor X,
factor X is also found in intrinsic and extrinsic pathways.
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