, Woo 1
Pharmacotherapeutics for APN Prescribers, 6e x x x x Ch01
Chapter 1. The Role of the Advanced Practice Nurse as Prescriber
x x x x x x x x x x
MULTIPLE CHOICE x
1. Nurse practitioner prescriptive authority is regulated by:
x x x x x x
A. The National Council of State Boards of Nursing
x x x x x x x
B. The U.S. Drug Enforcement Administration
x x x x
C. The State Board of Nursing for each state
x x x x x x x
D. The State Board of Pharmacy
x x x x
ANS: C x PTS: x 1
2. The benefits to the patient of having an advanced practice registered nurse (APRN) prescriber
x x x x x x x x x x x x x
include:
x
A. Nurses know more about pharmacology than other prescribers because they take it
x x x x x x x x x x x
both in their basic nursing program and in their APRN program.
x x x x x x x x x x x
B. Nurses care for the patient from a holistic approach and include the patient in
x x x x x x x x x x x x x
decision-making regarding their care.
x x x x
C. APRNs are less likely to prescribe narcotics and other controlled substances.
x x x x x x x x x x
D. APRNs are able to prescribe independently in all states, whereas a physician’s
x x x x x x x x x x x
assistant needs to have a physician supervising their practice.
x x x x x x x x x
ANS: B x PTS: x 1
3. Clinical judgment in prescribing includes:
x x x x
A. Factoring in the cost to the patient of the medication prescribed
x x x x x x x x x x
B. Always prescribing the newest medication available for the disease process
x x x x x x x x x
C. Handing out drug samples to poor patients x x x x x x
D. Prescribing all generic medications to cut costs x x x x x x
ANS: A x PTS: x 1
4. The process for choosing an effective drug for a disorder includes:
x x x x x x x x x x
A. Asking the patient what drug they think would work best for them
x x x x x x x x x x x
B. Consulting nationally recognized guidelines for disease management
x x x x x x
C. Prescribing medications that are available as samples before writing a prescription
x x x x x x x x x x
D. Following U.S. Drug Enforcement Administration guidelines for prescribing
x x x x x x x
ANS: B x PTS: x 1
5. Nonintentional nonadherence of drug therapy may occur due to: x x x x x x x x
A. Belief that medication does not work
x x x x x
B. Adverse drug reactions x x
C. Chronic conditions that require daily therapy
x x x x x
D. Forgetfulness or distraction x x
ANS: D x PTS: x 1
, Woo 1
Pharmacotherapeutics for APN Prescribers, 6e x x x x Ch02
Chapter 2. Review of Basic Principles of Pharmacology
x x x x x x x
MULTIPLE CHOICE x
1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical
x x x x x x x x x x x
to prescribing because:
x x x
A. Distribution of drugs to target tissue may be affected. x x x x x x x x
B. The solubility of the drug will not match the site of absorption.
x x x x x x x x x x x
C. There will be less free drug available to generate an effect.
x x x x x x x x x x
D. Drugs bound to albumin are readily excreted by the kidneys.
x x x x x x x x x
ANS: A x PTS: x 1
2. Drugs that have a significant first-pass effect:
x x x x x x
A. Must be given by the enteral (oral) route only
x x x x x x x x
B. Bypass the hepatic circulation x x x
C. Are rapidly metabolized by the liver and may have little, if any, desired action
x x x x x x x x x x x x x
D. Are converted by the liver to more active and fat-soluble forms
x x x x x x x x x x
ANS: C x PTS: x 1
3. The route of excretion of a volatile drug will likely be the:
x x x x x x x x x x x
A. Kidneys
B. Lungs
C. Bile and feces x x
D. Skin
ANS: B x PTS: x 1
4. A major disadvantage to IV administration is that:
x x x x x x x
A. First-pass metabolism is eliminated. x x x
B. Needles and sterility are required. x x x x
C. Absorption of the drug cannot be slowed after administration. x x x x x x x x
D. It is significantly more expensive than other routes.
x x x x x x x
ANS: C x PTS: xx x 1
5. The nurse practitioner (NP) chooses to give cephalexin every 8 hours based on knowledge of
x x x x x x x x x x x x x x
the drug’s:
x x
A. Propensity to go to the target receptor x x x x x x
B. Biological half-life x
C. Pharmacodynamics
D. Safety and side effects x x x
ANS: B x PTS: x 1
6. Deferasirox is a chelating agent used to treat iron overload by binding iron to render it
x x x x x x x x x x x x x x x
biologically inactive. This is best characterized as a(n):
x x x x x x x x
, Woo 2
Pharmacotherapeutics for APN Prescribers, 6e x x x x Ch02
A. Nonreceptor mechanism x
B. Partial agonist x
C. Full agonistx
D. Noncompetitive antagonist x
ANS: A x PTS: x 1
7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic
x x x x x x x x x x x x x x x x
effect is the:
x x x
A. Minimum adverse effect level x x x
B. Peak of action x x
C. Onset of action x x
D. Therapeutic range x
ANS: C x PTS: x 1
8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
x x x x x x x x x x x x x
A. When the drug has a wide therapeutic range
x x x x x x x
B. When the drug will be administered for a short time only
x x x x x x x x x x
C. When there is a high correlation between the dose and saturation of receptor sites
x x x x x x x x x x x x x
D. To determine if a drug is in the therapeutic range
x x x x x x x x x
ANS: D x PTS: x 1
9. A laboratory result indicates that the peak level for a drug is above the minimum toxic
x x x x x x x x x x x x x x x
concentration. This means that the:
x x x x x
A. Concentration will produce therapeutic effects. x x x x
B. Concentration will produce an adverse response. x x x x x
C. Time between doses must be shortened.
x x x x x
D. Duration of action of the drug is too long. x x x x x x x x
ANS: B x PTS: x 1
10. Drugs that are receptor agonists may demonstrate what property?
x x x x x x x x
A. Irreversible binding to the drug receptor site x x x x x x
B. Up-regulation with chronic use x x x
C. Desensitization or down-regulation with continuous use x x x x x
D. Inverse relationship between drug concentration and drug action
x x x x x x x
ANS: C x PTS: x 1
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
x x x x x x x x x x
A. Down-regulation of the drug receptor x x x x
B. An exaggerated response if abruptly discontinued
x x x x x
C. Partial blockade of the effects of agonist drugs
x x x x x x x
D. An exaggerated response to competitive drug agonists
x x x x x x
ANS: B x PTS: x 1
Pharmacotherapeutics for APN Prescribers, 6e x x x x Ch01
Chapter 1. The Role of the Advanced Practice Nurse as Prescriber
x x x x x x x x x x
MULTIPLE CHOICE x
1. Nurse practitioner prescriptive authority is regulated by:
x x x x x x
A. The National Council of State Boards of Nursing
x x x x x x x
B. The U.S. Drug Enforcement Administration
x x x x
C. The State Board of Nursing for each state
x x x x x x x
D. The State Board of Pharmacy
x x x x
ANS: C x PTS: x 1
2. The benefits to the patient of having an advanced practice registered nurse (APRN) prescriber
x x x x x x x x x x x x x
include:
x
A. Nurses know more about pharmacology than other prescribers because they take it
x x x x x x x x x x x
both in their basic nursing program and in their APRN program.
x x x x x x x x x x x
B. Nurses care for the patient from a holistic approach and include the patient in
x x x x x x x x x x x x x
decision-making regarding their care.
x x x x
C. APRNs are less likely to prescribe narcotics and other controlled substances.
x x x x x x x x x x
D. APRNs are able to prescribe independently in all states, whereas a physician’s
x x x x x x x x x x x
assistant needs to have a physician supervising their practice.
x x x x x x x x x
ANS: B x PTS: x 1
3. Clinical judgment in prescribing includes:
x x x x
A. Factoring in the cost to the patient of the medication prescribed
x x x x x x x x x x
B. Always prescribing the newest medication available for the disease process
x x x x x x x x x
C. Handing out drug samples to poor patients x x x x x x
D. Prescribing all generic medications to cut costs x x x x x x
ANS: A x PTS: x 1
4. The process for choosing an effective drug for a disorder includes:
x x x x x x x x x x
A. Asking the patient what drug they think would work best for them
x x x x x x x x x x x
B. Consulting nationally recognized guidelines for disease management
x x x x x x
C. Prescribing medications that are available as samples before writing a prescription
x x x x x x x x x x
D. Following U.S. Drug Enforcement Administration guidelines for prescribing
x x x x x x x
ANS: B x PTS: x 1
5. Nonintentional nonadherence of drug therapy may occur due to: x x x x x x x x
A. Belief that medication does not work
x x x x x
B. Adverse drug reactions x x
C. Chronic conditions that require daily therapy
x x x x x
D. Forgetfulness or distraction x x
ANS: D x PTS: x 1
, Woo 1
Pharmacotherapeutics for APN Prescribers, 6e x x x x Ch02
Chapter 2. Review of Basic Principles of Pharmacology
x x x x x x x
MULTIPLE CHOICE x
1. A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This is critical
x x x x x x x x x x x
to prescribing because:
x x x
A. Distribution of drugs to target tissue may be affected. x x x x x x x x
B. The solubility of the drug will not match the site of absorption.
x x x x x x x x x x x
C. There will be less free drug available to generate an effect.
x x x x x x x x x x
D. Drugs bound to albumin are readily excreted by the kidneys.
x x x x x x x x x
ANS: A x PTS: x 1
2. Drugs that have a significant first-pass effect:
x x x x x x
A. Must be given by the enteral (oral) route only
x x x x x x x x
B. Bypass the hepatic circulation x x x
C. Are rapidly metabolized by the liver and may have little, if any, desired action
x x x x x x x x x x x x x
D. Are converted by the liver to more active and fat-soluble forms
x x x x x x x x x x
ANS: C x PTS: x 1
3. The route of excretion of a volatile drug will likely be the:
x x x x x x x x x x x
A. Kidneys
B. Lungs
C. Bile and feces x x
D. Skin
ANS: B x PTS: x 1
4. A major disadvantage to IV administration is that:
x x x x x x x
A. First-pass metabolism is eliminated. x x x
B. Needles and sterility are required. x x x x
C. Absorption of the drug cannot be slowed after administration. x x x x x x x x
D. It is significantly more expensive than other routes.
x x x x x x x
ANS: C x PTS: xx x 1
5. The nurse practitioner (NP) chooses to give cephalexin every 8 hours based on knowledge of
x x x x x x x x x x x x x x
the drug’s:
x x
A. Propensity to go to the target receptor x x x x x x
B. Biological half-life x
C. Pharmacodynamics
D. Safety and side effects x x x
ANS: B x PTS: x 1
6. Deferasirox is a chelating agent used to treat iron overload by binding iron to render it
x x x x x x x x x x x x x x x
biologically inactive. This is best characterized as a(n):
x x x x x x x x
, Woo 2
Pharmacotherapeutics for APN Prescribers, 6e x x x x Ch02
A. Nonreceptor mechanism x
B. Partial agonist x
C. Full agonistx
D. Noncompetitive antagonist x
ANS: A x PTS: x 1
7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic
x x x x x x x x x x x x x x x x
effect is the:
x x x
A. Minimum adverse effect level x x x
B. Peak of action x x
C. Onset of action x x
D. Therapeutic range x
ANS: C x PTS: x 1
8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
x x x x x x x x x x x x x
A. When the drug has a wide therapeutic range
x x x x x x x
B. When the drug will be administered for a short time only
x x x x x x x x x x
C. When there is a high correlation between the dose and saturation of receptor sites
x x x x x x x x x x x x x
D. To determine if a drug is in the therapeutic range
x x x x x x x x x
ANS: D x PTS: x 1
9. A laboratory result indicates that the peak level for a drug is above the minimum toxic
x x x x x x x x x x x x x x x
concentration. This means that the:
x x x x x
A. Concentration will produce therapeutic effects. x x x x
B. Concentration will produce an adverse response. x x x x x
C. Time between doses must be shortened.
x x x x x
D. Duration of action of the drug is too long. x x x x x x x x
ANS: B x PTS: x 1
10. Drugs that are receptor agonists may demonstrate what property?
x x x x x x x x
A. Irreversible binding to the drug receptor site x x x x x x
B. Up-regulation with chronic use x x x
C. Desensitization or down-regulation with continuous use x x x x x
D. Inverse relationship between drug concentration and drug action
x x x x x x x
ANS: C x PTS: x 1
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
x x x x x x x x x x
A. Down-regulation of the drug receptor x x x x
B. An exaggerated response if abruptly discontinued
x x x x x
C. Partial blockade of the effects of agonist drugs
x x x x x x x
D. An exaggerated response to competitive drug agonists
x x x x x x
ANS: B x PTS: x 1