Netter's Essential Histology: With Correlated Histopathology 3rd Edition
Ovalle: Netter’s Essential Histology, 3rd Edition
Chapter 1: The Cell
Test Bank
MULTIPLE CHOICE
1. Rough endoplasmic reticulum (RER) in the cell cytoplasm is
intensely stained by hematoxylin because hematoxylin:
a. Attaches to lipids in RER membranes
b. Binds readily to RNA
c. Catalyzes the precipitation of ribosomes into a dense, readily stained matrix
d. Is an acid dye and binds to acidophilic ribosomal proteins
e. Reacts with carbohydrate molecules of integral membrane proteins
ANS: B
The metal ions associated with hematoxylin impart a positive charge to the dye, which enables it to
bind to negatively charged molecules like acids (e.g., ribonucleic acid). See 1-1.
2. Staining a specimen using immunocytochemical methods detects the presence of:
a. Lipids with multiple double bonds between carbon atoms
b. Organelles with an above average optical density
c. Specific types of carbohydrates
d. Specific proteins
e. Specific sequences of RNA
ANS: D
Antibodies are typically used to bind to specific proteins; specific sequences of RNA are detected by
in situ hybridization histochemical techniques. See 1-23.
Copyright © 2021 by Elsevier, Inc. All rights reserved.
,Netter's Essential Histology: With Correlated Histopathology 3rd Edition
3. Desmin is an intermediate filament protein that is specifically localized in:
a. Astrocytes
b. Cardiac muscle
c. Lymphocytes
d. Macrophages
e. Simple cuboidal epithelial cells
ANS: B
Cells in each of the four classes of tissue produce intermediate filaments specific for that class of
cells; desmin is the intermediate filament specific for muscle. See 1-24.
4. Numerous mitochondria possessing unusual tubular cristae are a distinguishing anatomic feature
of:
a. Exocrine pancreatic acinar cells
b. Nerve cells of the cerebral cortex
c. Pancreatic islet cells
d. Skeletal muscle cells
e. Steroid-secreting cells in the adrenal cortex
ANS: E
Mitochondria possess enzymes required for critical steps in steroid synthesis; why these enzymes are
associated with tubular cristae is not yet known. See 1-12.
5. Tay-Sachs disease results from abnormalities in:
a. Keratin
b. Lysosomes
c. Microtubules
d. Mitochondria
e. Rough endoplasmic reticulum
ANS: B
Copyright © 2021 by Elsevier, Inc. All rights reserved.
,Netter's Essential Histology: With Correlated Histopathology 3rd Edition
Tay-Sachs disease results from a deficiency of lysosomal hexosaminidase, leading to an accumulation
of gangliosides within cells. See 1-18.
6. Claudin is a protein that is functionally important in:
a. Gap junctions
b. Hemidesmosomes
c. Intermediate junctions
d. Synapses
e. Tight junctions
ANS: E
Claudin is essential for the formation of membrane fusions in tight junctions. See 1-5.
7. A function of the Golgi complex includes:
a. Degradation of abnormal proteins
b. Destruction of hydrogen peroxide
c. Glycosylation of proteins
d. Storage of calcium
e. Translation of messenger RNA
ANS: C
Golgi stacks are the site of O-linked glycosylation of proteins and for the addition of carbohydrate
molecules such as sialic acid. See 1-17.
8. Lipofuscin is a brownish pigment that may accumulate in:
a. Lipid droplets
b. Lysosomes
c. Mitochondria
d. Smooth endoplasmic reticulum
e. The cell nucleus
ANS: B
Copyright © 2021 by Elsevier, Inc. All rights reserved.
, Netter's Essential Histology: With Correlated Histopathology 3rd Edition
Lipofuscin represents the indigestible remnants of structures hydrolyzed in lysosomes. See 1-18.
Ovalle: Netter’s Essential Histology, 3rd Edition
Chapter 2: Epithelium and Exocrine Glands
Test Bank
MULTIPLE CHOICE
1. Goblet cells are typically found in which type of epithelium?
a. Pseudostratified columnar
b. Simple cuboidal
c. Simple squamous
d. Stratified squamous
e. Transitional
ANS: A
Tall, columnar mucus-secreting goblet cells are found only in association with other columnar
epithelial cells and differentiate under the influence of a protein called Math-1 that is produced
within this type of epithelium. See 2-6.
2. A serous demilune is defined as a(n):
a. A collection of secretory acini that drain into a single duct
b. An association of secretory vesicles at the apical surface of an epithelial cell
c. A bright-staining segment of a basal lamina beneath glandular epithelial cells
d. A collection of serous cells adjacent to mucus cells of a salivary gland
e. Simple cuboidal cells that constitute the duct portions of salivary glands
ANS: D
Swelling of mucus cells within a salivary gland during fixation of the tissue tends to compress
adjacent serous cells into a half-moon shaped “cap” at the end of a mixed secretory acinus. See 2-
16.
Copyright © 2021 by Elsevier, Inc. All rights reserved.
Ovalle: Netter’s Essential Histology, 3rd Edition
Chapter 1: The Cell
Test Bank
MULTIPLE CHOICE
1. Rough endoplasmic reticulum (RER) in the cell cytoplasm is
intensely stained by hematoxylin because hematoxylin:
a. Attaches to lipids in RER membranes
b. Binds readily to RNA
c. Catalyzes the precipitation of ribosomes into a dense, readily stained matrix
d. Is an acid dye and binds to acidophilic ribosomal proteins
e. Reacts with carbohydrate molecules of integral membrane proteins
ANS: B
The metal ions associated with hematoxylin impart a positive charge to the dye, which enables it to
bind to negatively charged molecules like acids (e.g., ribonucleic acid). See 1-1.
2. Staining a specimen using immunocytochemical methods detects the presence of:
a. Lipids with multiple double bonds between carbon atoms
b. Organelles with an above average optical density
c. Specific types of carbohydrates
d. Specific proteins
e. Specific sequences of RNA
ANS: D
Antibodies are typically used to bind to specific proteins; specific sequences of RNA are detected by
in situ hybridization histochemical techniques. See 1-23.
Copyright © 2021 by Elsevier, Inc. All rights reserved.
,Netter's Essential Histology: With Correlated Histopathology 3rd Edition
3. Desmin is an intermediate filament protein that is specifically localized in:
a. Astrocytes
b. Cardiac muscle
c. Lymphocytes
d. Macrophages
e. Simple cuboidal epithelial cells
ANS: B
Cells in each of the four classes of tissue produce intermediate filaments specific for that class of
cells; desmin is the intermediate filament specific for muscle. See 1-24.
4. Numerous mitochondria possessing unusual tubular cristae are a distinguishing anatomic feature
of:
a. Exocrine pancreatic acinar cells
b. Nerve cells of the cerebral cortex
c. Pancreatic islet cells
d. Skeletal muscle cells
e. Steroid-secreting cells in the adrenal cortex
ANS: E
Mitochondria possess enzymes required for critical steps in steroid synthesis; why these enzymes are
associated with tubular cristae is not yet known. See 1-12.
5. Tay-Sachs disease results from abnormalities in:
a. Keratin
b. Lysosomes
c. Microtubules
d. Mitochondria
e. Rough endoplasmic reticulum
ANS: B
Copyright © 2021 by Elsevier, Inc. All rights reserved.
,Netter's Essential Histology: With Correlated Histopathology 3rd Edition
Tay-Sachs disease results from a deficiency of lysosomal hexosaminidase, leading to an accumulation
of gangliosides within cells. See 1-18.
6. Claudin is a protein that is functionally important in:
a. Gap junctions
b. Hemidesmosomes
c. Intermediate junctions
d. Synapses
e. Tight junctions
ANS: E
Claudin is essential for the formation of membrane fusions in tight junctions. See 1-5.
7. A function of the Golgi complex includes:
a. Degradation of abnormal proteins
b. Destruction of hydrogen peroxide
c. Glycosylation of proteins
d. Storage of calcium
e. Translation of messenger RNA
ANS: C
Golgi stacks are the site of O-linked glycosylation of proteins and for the addition of carbohydrate
molecules such as sialic acid. See 1-17.
8. Lipofuscin is a brownish pigment that may accumulate in:
a. Lipid droplets
b. Lysosomes
c. Mitochondria
d. Smooth endoplasmic reticulum
e. The cell nucleus
ANS: B
Copyright © 2021 by Elsevier, Inc. All rights reserved.
, Netter's Essential Histology: With Correlated Histopathology 3rd Edition
Lipofuscin represents the indigestible remnants of structures hydrolyzed in lysosomes. See 1-18.
Ovalle: Netter’s Essential Histology, 3rd Edition
Chapter 2: Epithelium and Exocrine Glands
Test Bank
MULTIPLE CHOICE
1. Goblet cells are typically found in which type of epithelium?
a. Pseudostratified columnar
b. Simple cuboidal
c. Simple squamous
d. Stratified squamous
e. Transitional
ANS: A
Tall, columnar mucus-secreting goblet cells are found only in association with other columnar
epithelial cells and differentiate under the influence of a protein called Math-1 that is produced
within this type of epithelium. See 2-6.
2. A serous demilune is defined as a(n):
a. A collection of secretory acini that drain into a single duct
b. An association of secretory vesicles at the apical surface of an epithelial cell
c. A bright-staining segment of a basal lamina beneath glandular epithelial cells
d. A collection of serous cells adjacent to mucus cells of a salivary gland
e. Simple cuboidal cells that constitute the duct portions of salivary glands
ANS: D
Swelling of mucus cells within a salivary gland during fixation of the tissue tends to compress
adjacent serous cells into a half-moon shaped “cap” at the end of a mixed secretory acinus. See 2-
16.
Copyright © 2021 by Elsevier, Inc. All rights reserved.
