2024 APHA NAPLEX REVIEW EXAM
QUESTIONS WITH CORRECT
ANSWERS
If the pka of a weak acid is 2.5, at which pH will this drug become more
ionized?
A. pH 5
B. pH 2.5
C. pH 1.5
D. pH 1 - CORRECT-ANSWERSA. For a weak acid, a higher pH increases
ionization
Which equation describes the rate of drug dissolution from a tablet?
A. Fick's Law
B. Henderson-Hasselbalch equation
C. Michaelis-Menten equation
D. Noyes-Whitney equation - CORRECT-ANSWERSD. The Noyes-Whitney
equation describes the rate of drug dissolution from a tablet. Fick's first law
of diffusion is similar to the Noyes-Whitney equation in that both equations
describe drug movement attributable to a concentration gradient. The
Michealis-Menten equation involves enzyme kinetics, whereas Henderson-
Hasselbalch equations are used for determination of pH of the buffer and the
extent of ionization of a drug molecule
The pH of a buffer system can be calculated with
A. the Henderson-Hasselbalch equation
B. the Noyes-Whitney equation
C. the Michealis-Mention equation
D. Yong's equation - CORRECT-ANSWERSA. The Henderson-Hasselbalch
equation form a weak acid and its salt is represented as pH = pka + log
([salt]/[acid]), where pka is the negative log of the dissolution constant of a
weak acid, as [salt]/[acid] is the ratio of the molar concentration of salt and
acid used to prepare a buffer
Which of the following radiopharmaceuticals is a monovalent cation and a
potassium analog?
,A. F-18 FDG
B. Tc-99m tetrofosmin
C. Tc-99m sestamibi
D. Thallous chloride T1-201 - CORRECT-ANSWERSD. F-18 FDG is a glucose
analog; Tc-99m tetrofosmin and Tc-99m sestamibi are monovalent cations
but not potassium analogs; thallous chloride T1-201 is a monovalent cation
and a potassium analog
Which of the following PET radiopharmaceuticals is commercially available
from a generator?
A. F-18 FDG
B. I-23 ioflupane
C. Florbetapir F-18
D. Rb-82 chloride - CORRECT-ANSWERSD. F-18 and I-123 are not available
from a generator
Which of the following is a myocardial radiopharmaceutical that provides
information on both perfusion and left ventricular function?
A. Rb-82 chloride
B. Tc-99m tetrofosmin
C. F-18 FDG
D. Thallous chloride T1-201 - CORRECT-ANSWERSB. F-18 FDG is an indicator
of metabolism, Rb-82 chloride and thallous chloride provide information on
myocardial perfusion. Tc-99m tetrofosmin provides information on both
myocardial perfusion and left ventricular fn
An example of a diagnostic skeletal agent is
A. Tc-99m bicisate
B. Tc-99m MDP
C. Sr-82 chloride
D. Florbetapir F-18 - CORRECT-ANSWERSB. Tc-99m bicisate and florbetapir F-
18 are for CNS imaging. Sr 82 chloride is a palliative therapeutic agent
What patient preparation is recommended for skeletal imaging if the
patient's condition permits?
A. bowel cleansing
B. hydration
C. thyroid blockade
D. sincalide administration - CORRECT-ANSWERSB. Hydration is
recommended.
, Which of the following correctly characterizes Tc-99m HDP?
A. localizes in areas of high bone metabolic activity
B. limited to use in adult patients with metastatic lesions
C. frequent adverse reactions
D. lipophilic cationic complex - CORRECT-ANSWERSA. Tc-99m HDP can be
used in the pediatric population, and adverse reactions are uncommon. It is
a diphosphonate complex but not a lipophilic complex
Which of the following radiopharmaceuticals exerts it palliative effect
through its beta particle emission?
A. Tc-99m MDP
B. In-111 oxyquinoline
C. I-123 iobenguane
D. Sm-153 EDTMP - CORRECT-ANSWERSD. Sm-153 EDTMP produces beta
particles
Which of the following radiopharmaceuticals is indicated for radiolabeling
leukocytes?
A. Tc-99m DTPA
B. F-18 FDG
C. In-111 oxine
D. I-123 iobenguane - CORRECT-ANSWERSC. In-111 oxine; Tc-99m DTPA is
used in brain and renal studies, F-18 FDG is used as a metabolic indicator,
and I-123 iobenguane is used in the detection of pheochromocytomas and
neuroblastomas
An example of a radiolabeled peptide that is used in localized primary and
metastatic neuroendocrine tumors is
A. In-111 pentetreotide
B. I-123 iobenguane
C. In-111 capromab pendetide
D. I-123 ioflupane - CORRECT-ANSWERSA. I-123 benguane is used in the
detection of pheochromocytomas and neuroblastomas, but is not a peptide,
In-111 capromab is a monoclonal antibody used in pts with prostate cancer.
I-123 ioflupane is used in the eval of pts with parkinsonian syndromes
Which of the following PET radiopharmaceuticals is used for assessing
malignant and benign skeletal disease?
A. F-18 FDG
B. Florbetapir F-18
C. Rb-82 chloride
QUESTIONS WITH CORRECT
ANSWERS
If the pka of a weak acid is 2.5, at which pH will this drug become more
ionized?
A. pH 5
B. pH 2.5
C. pH 1.5
D. pH 1 - CORRECT-ANSWERSA. For a weak acid, a higher pH increases
ionization
Which equation describes the rate of drug dissolution from a tablet?
A. Fick's Law
B. Henderson-Hasselbalch equation
C. Michaelis-Menten equation
D. Noyes-Whitney equation - CORRECT-ANSWERSD. The Noyes-Whitney
equation describes the rate of drug dissolution from a tablet. Fick's first law
of diffusion is similar to the Noyes-Whitney equation in that both equations
describe drug movement attributable to a concentration gradient. The
Michealis-Menten equation involves enzyme kinetics, whereas Henderson-
Hasselbalch equations are used for determination of pH of the buffer and the
extent of ionization of a drug molecule
The pH of a buffer system can be calculated with
A. the Henderson-Hasselbalch equation
B. the Noyes-Whitney equation
C. the Michealis-Mention equation
D. Yong's equation - CORRECT-ANSWERSA. The Henderson-Hasselbalch
equation form a weak acid and its salt is represented as pH = pka + log
([salt]/[acid]), where pka is the negative log of the dissolution constant of a
weak acid, as [salt]/[acid] is the ratio of the molar concentration of salt and
acid used to prepare a buffer
Which of the following radiopharmaceuticals is a monovalent cation and a
potassium analog?
,A. F-18 FDG
B. Tc-99m tetrofosmin
C. Tc-99m sestamibi
D. Thallous chloride T1-201 - CORRECT-ANSWERSD. F-18 FDG is a glucose
analog; Tc-99m tetrofosmin and Tc-99m sestamibi are monovalent cations
but not potassium analogs; thallous chloride T1-201 is a monovalent cation
and a potassium analog
Which of the following PET radiopharmaceuticals is commercially available
from a generator?
A. F-18 FDG
B. I-23 ioflupane
C. Florbetapir F-18
D. Rb-82 chloride - CORRECT-ANSWERSD. F-18 and I-123 are not available
from a generator
Which of the following is a myocardial radiopharmaceutical that provides
information on both perfusion and left ventricular function?
A. Rb-82 chloride
B. Tc-99m tetrofosmin
C. F-18 FDG
D. Thallous chloride T1-201 - CORRECT-ANSWERSB. F-18 FDG is an indicator
of metabolism, Rb-82 chloride and thallous chloride provide information on
myocardial perfusion. Tc-99m tetrofosmin provides information on both
myocardial perfusion and left ventricular fn
An example of a diagnostic skeletal agent is
A. Tc-99m bicisate
B. Tc-99m MDP
C. Sr-82 chloride
D. Florbetapir F-18 - CORRECT-ANSWERSB. Tc-99m bicisate and florbetapir F-
18 are for CNS imaging. Sr 82 chloride is a palliative therapeutic agent
What patient preparation is recommended for skeletal imaging if the
patient's condition permits?
A. bowel cleansing
B. hydration
C. thyroid blockade
D. sincalide administration - CORRECT-ANSWERSB. Hydration is
recommended.
, Which of the following correctly characterizes Tc-99m HDP?
A. localizes in areas of high bone metabolic activity
B. limited to use in adult patients with metastatic lesions
C. frequent adverse reactions
D. lipophilic cationic complex - CORRECT-ANSWERSA. Tc-99m HDP can be
used in the pediatric population, and adverse reactions are uncommon. It is
a diphosphonate complex but not a lipophilic complex
Which of the following radiopharmaceuticals exerts it palliative effect
through its beta particle emission?
A. Tc-99m MDP
B. In-111 oxyquinoline
C. I-123 iobenguane
D. Sm-153 EDTMP - CORRECT-ANSWERSD. Sm-153 EDTMP produces beta
particles
Which of the following radiopharmaceuticals is indicated for radiolabeling
leukocytes?
A. Tc-99m DTPA
B. F-18 FDG
C. In-111 oxine
D. I-123 iobenguane - CORRECT-ANSWERSC. In-111 oxine; Tc-99m DTPA is
used in brain and renal studies, F-18 FDG is used as a metabolic indicator,
and I-123 iobenguane is used in the detection of pheochromocytomas and
neuroblastomas
An example of a radiolabeled peptide that is used in localized primary and
metastatic neuroendocrine tumors is
A. In-111 pentetreotide
B. I-123 iobenguane
C. In-111 capromab pendetide
D. I-123 ioflupane - CORRECT-ANSWERSA. I-123 benguane is used in the
detection of pheochromocytomas and neuroblastomas, but is not a peptide,
In-111 capromab is a monoclonal antibody used in pts with prostate cancer.
I-123 ioflupane is used in the eval of pts with parkinsonian syndromes
Which of the following PET radiopharmaceuticals is used for assessing
malignant and benign skeletal disease?
A. F-18 FDG
B. Florbetapir F-18
C. Rb-82 chloride
