ATSU SOMA NSAIDs "Left Ankle Sprain" well answered graded A+

ATSU SOMA NSAIDs "Left Ankle Sprain"

Ibuprofen MOA - correct answer ✔✔MOA: Reversible inhibition of COX-1 and COX-2; decreased
prostaglandin (inflammatory signaling molecule) synthesis



Dosage and mode of use for Ibuprofen - correct answer ✔✔600 mg QID



Topical cream, Oral, IV



Ibuprofen Contraindications - correct answer ✔✔CI:

1. Gastroduodenal ulcers

2. Acute hemorrhage

3. Renal failure

4. Recent MI

5. 1-3 days prior to surgery

6. Pregnancy



Ibuprofen indications - correct answer ✔✔Indications:

1. RA

2. Inflammatory arthritis

3. Kawasaki disease

4. Gout

5. Post-op pain

6. Dysmenorrhoea

7. Headache, migraine

8. Fever

9. Closure of patent ductus arteriosus

, Ibuprofen side effects - correct answer ✔✔Side effects:

1. Gastric and duodenal ulcers with risk of GI bleeding and perforation

2. Increase risk of MI and stroke

3. Renal function impairment

4. Aplastic anemia (body fails to produce sufficient blood cells)



Diclofenac MOA - correct answer ✔✔MOA: Reversible inhibition of COX-1 and COX-2; decreased
prostaglandin (inflammatory signaling molecule) synthesis



Dosage and mode of use for Diclofenac - correct answer ✔✔50-75 mg BID



Topical gel, Rectal suppository, sodium, potassium and epolamine salts



Diclofenac contraindications - correct answer ✔✔CI:

1. Gastroduodenal ulcers

2. Acute hemorrhage

3. Renal failure

4. Recent MI

5. 1-3 days prior to surgery

6. Pregnancy



Diclofenac indications - correct answer ✔✔Indications:

1. RA

2. Inflammatory arthritis

3. Kawasaki disease

4. Gout

5. Post-op pain

6. Dysmenorrhoea

7. Headache, migraine