CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
1. The combination of squamous cell carcinoma antigen (SCCA) and CYFRA
21-1 test results can be used to provide reliable laboratory data for the
differential diagnosis of which disease?
A. Nonsquamous cell lung carcinoma
B. Pancreatic cancer
C. Liver cancer
D. Pulmonary embolism - CORRECT ANSWERS A. Nonsquamous cell lung
carcinoma
2. "A progressive systemic skeletal disease characterized by low bone mass
and micro architectural deterioration of bone tissue, with a consequent
increase in bone fragility and susceptible to fracture" describes which of the
following diseases?
A. Osteosarcoma
B. Osteoporosis
C. Renal osteodystrophy
D. Paget's disease - CORRECT ANSWERS B. Osteoporosis
3. A markedly elevated serum AFP is associated with which of the
following?
A. Ovarian cancer
B. Lung cancer
C. Hepatoma
D. Breast cancer - CORRECT ANSWERS C. Hepatoma
4. Which of the following is a sialylated Lewis blood group antigen
associated with colorectal cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - CORRECT ANSWERS D. CA 19-9
,CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
5. Which of the following biomarkers are elevated in advanced stages of
breast cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
D. DUPAN-2 and Gastrin - CORRECT ANSWERS C. CA 15-3 and CA 549
6. Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
D. Nuclear matrix protein - CORRECT ANSWERS D. Nuclear matrix protein
7. What is the primary clinical usefulness of measuring carcinoembryonic
antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - CORRECT ANSWERS D.
Monitoring for recurrence of colon cancer
8. Which of the following is used to assess the usefulness of trastuzumab
(Herceptin®) therapy for breast cancer?
A. CA 15-3
B. HER-2/neu
C. CA 125
D. Prolactin - CORRECT ANSWERS B. HER-2/neu
,CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
9. Which type of hCG test would be most useful to assess a person
suspected of having testicular cancer?
A. Plasma immunoassay for intact hCG and the β-hCG subunits
B. Plasma immunoassay fro the free alpha and β-hCG subunits
C. Urine assay for hCG-β core
D. Plasma immunoassay for intact hCG only - CORRECT ANSWERS A.
Plasma immunoassay for intact hCG and the β-hCG subunits
10. Which of the following biomarkers is elevated in nonmucinous
epithelial ovarian cancer?
A. CA 15-3
B. CA 19-9
C. CA 125
D. CEA - CORRECT ANSWERS C. CA 125
11. Which of the following assays is recommended as a screening test for
colorectal cancer in persons over 50 years of age?
A. Fecal typsin
B. AFP
C. BTA
D. Occult blood t test - CORRECT ANSWERS D. Occult blood test
12. Which of the following must be determined to calculate diagnostic
specificity?
A. True-negatives and false-positives
B. True-positives and false-positives
C. True-positives and false-negatives
D. True-negatives and false-negatives - CORRECT ANSWERS A. True-
negatives and false-positives
, CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
13. A new tumor marker assay for prostate specific antigen (PSA) is
evaluated for sensitivity by testing serum samples from patients who have
been diagnosed as having prostate cancer. The following results were
obtained:
Number of prostate cancer patients who tested positive by the new assay =
42 out 46
Number of patients who did not have cancer and tested negative by the new
assay = 31 out of 32
What is the sensitivity of the new assay for PSA?
A. 98.0%
B. 95.0%
C. 91.3%
D. 88.5% - CORRECT ANSWERS C. 91.3%
14. Which statement below best describes the molecular difference
between free PSA (fPSA) and complex PSA (cPSA)?
A. Free PSA is bound by compounds such as ACT, PCI, API, or AMG
B. Free PSA is an active form that can complex with protease inhibitors
C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
D. Free PSA cannot be detected in serum, whereas complex PSA can -
CORRECT ANSWERS C. Free PSA is not bound by compounds such as ACT,
PCI, API, or AMG
15. The production of alpha fetal protein (AFP) in a healthy individual is
best reflected by which of the following statements?
A. The production of AFP remains the same through life
B. The production of AFP declines rapidly at birth and healthy adults and
children have negligible or undetectable levels in serum
C. The production of AFP declines rapidly at birth and healthy adults and
children have higher than normal levels in serum
D. The production of AFP declines rapidly at birth and healthy adults and
children have negligible or undetectable levels in serum - CORRECT
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
1. The combination of squamous cell carcinoma antigen (SCCA) and CYFRA
21-1 test results can be used to provide reliable laboratory data for the
differential diagnosis of which disease?
A. Nonsquamous cell lung carcinoma
B. Pancreatic cancer
C. Liver cancer
D. Pulmonary embolism - CORRECT ANSWERS A. Nonsquamous cell lung
carcinoma
2. "A progressive systemic skeletal disease characterized by low bone mass
and micro architectural deterioration of bone tissue, with a consequent
increase in bone fragility and susceptible to fracture" describes which of the
following diseases?
A. Osteosarcoma
B. Osteoporosis
C. Renal osteodystrophy
D. Paget's disease - CORRECT ANSWERS B. Osteoporosis
3. A markedly elevated serum AFP is associated with which of the
following?
A. Ovarian cancer
B. Lung cancer
C. Hepatoma
D. Breast cancer - CORRECT ANSWERS C. Hepatoma
4. Which of the following is a sialylated Lewis blood group antigen
associated with colorectal cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - CORRECT ANSWERS D. CA 19-9
,CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
5. Which of the following biomarkers are elevated in advanced stages of
breast cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
D. DUPAN-2 and Gastrin - CORRECT ANSWERS C. CA 15-3 and CA 549
6. Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
D. Nuclear matrix protein - CORRECT ANSWERS D. Nuclear matrix protein
7. What is the primary clinical usefulness of measuring carcinoembryonic
antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - CORRECT ANSWERS D.
Monitoring for recurrence of colon cancer
8. Which of the following is used to assess the usefulness of trastuzumab
(Herceptin®) therapy for breast cancer?
A. CA 15-3
B. HER-2/neu
C. CA 125
D. Prolactin - CORRECT ANSWERS B. HER-2/neu
,CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
9. Which type of hCG test would be most useful to assess a person
suspected of having testicular cancer?
A. Plasma immunoassay for intact hCG and the β-hCG subunits
B. Plasma immunoassay fro the free alpha and β-hCG subunits
C. Urine assay for hCG-β core
D. Plasma immunoassay for intact hCG only - CORRECT ANSWERS A.
Plasma immunoassay for intact hCG and the β-hCG subunits
10. Which of the following biomarkers is elevated in nonmucinous
epithelial ovarian cancer?
A. CA 15-3
B. CA 19-9
C. CA 125
D. CEA - CORRECT ANSWERS C. CA 125
11. Which of the following assays is recommended as a screening test for
colorectal cancer in persons over 50 years of age?
A. Fecal typsin
B. AFP
C. BTA
D. Occult blood t test - CORRECT ANSWERS D. Occult blood test
12. Which of the following must be determined to calculate diagnostic
specificity?
A. True-negatives and false-positives
B. True-positives and false-positives
C. True-positives and false-negatives
D. True-negatives and false-negatives - CORRECT ANSWERS A. True-
negatives and false-positives
, CLINICAL CHEM TEST BANK (FINAL EXAM) QUESTIONS AND
ANSWERS LATEST UPDATE 2024/2025 BEST RATED A+
13. A new tumor marker assay for prostate specific antigen (PSA) is
evaluated for sensitivity by testing serum samples from patients who have
been diagnosed as having prostate cancer. The following results were
obtained:
Number of prostate cancer patients who tested positive by the new assay =
42 out 46
Number of patients who did not have cancer and tested negative by the new
assay = 31 out of 32
What is the sensitivity of the new assay for PSA?
A. 98.0%
B. 95.0%
C. 91.3%
D. 88.5% - CORRECT ANSWERS C. 91.3%
14. Which statement below best describes the molecular difference
between free PSA (fPSA) and complex PSA (cPSA)?
A. Free PSA is bound by compounds such as ACT, PCI, API, or AMG
B. Free PSA is an active form that can complex with protease inhibitors
C. Free PSA is not bound by compounds such as ACT, PCI, API, or AMG
D. Free PSA cannot be detected in serum, whereas complex PSA can -
CORRECT ANSWERS C. Free PSA is not bound by compounds such as ACT,
PCI, API, or AMG
15. The production of alpha fetal protein (AFP) in a healthy individual is
best reflected by which of the following statements?
A. The production of AFP remains the same through life
B. The production of AFP declines rapidly at birth and healthy adults and
children have negligible or undetectable levels in serum
C. The production of AFP declines rapidly at birth and healthy adults and
children have higher than normal levels in serum
D. The production of AFP declines rapidly at birth and healthy adults and
children have negligible or undetectable levels in serum - CORRECT
