1 | P a g e | © copyright 2024/2025 | Grade A+
CMB2004 Questions and Answer |
Latest Update 2024/2025
Are B and T lymphocytes part of the adaptive or innate immune response?
✓ ~~> Adaptive it is the immune memory evolved over time
What is the clonal selection theory?
✓ ~~> Immature lymphocytes that could self find are destroyed
Mature naive lymphocytes are mature until they are exposed to antigens
What are the two types of B receptor?
✓ ~~> Membrane bound
And released from membrane they are known as antibodies
T cell receptors are only membrane bound and are formed of what
heterodimer?
✓ ~~> Alpha and beta chains
Antibodies are formed if a light and heavy chain, what interactions are there
between the two?
Master01 | September, 2024/2025 | Latest update
, 2 | P a g e | © copyright 2024/2025 | Grade A+
✓ ~~> Disulphide bridge (Hinge region)
And non covalent interactions
What forms the N terminal region of an antibody?
✓ ~~> The antigen binding site of the light and heavy chain known as
the variable region
The C terminal constant region is also known as what?
✓ ~~> The FC region (fragment crystallisable)
The region containing the variable region is called FAB (fragment antigen
binding)
Glycosylation of C2 modulates binding of heavy chain
The light chains are either lambda or kappa, what chromosome encodes
each?
✓ ~~> Lambda = chromosome 22 - 30 V genes and 7J
Kappa = chromosome 2 - 52 V genes and 5J
There are 5 isotopes of antibody, what are they?
Master01 | September, 2024/2025 | Latest update
, 3 | P a g e | © copyright 2024/2025 | Grade A+
✓ ~~> IgM, IgD, IgG, IgE, IgA
How many hyper variable loops are there in total?
✓ ~~> 6
3 in Vh and Vl
What are complimentary determing regions?
✓ ~~> Sections of the variable region which bind the antigen
What is an epitope?
✓ ~~> the part of an antigen molecule to which an antibody attaches
itself
Can be linear = continuous
Conformational = discontinuous
Multitalented antigen - antigen with more than one epitope
What is MHC called in humans?
✓ ~~> Human Leukocyte Antigen (HLA)
Master01 | September, 2024/2025 | Latest update
, 4 | P a g e | © copyright 2024/2025 | Grade A+
Which cells present MHCI?
And MHCII?
✓ ~~> I = on all nucleated cells
II = specialised immune cells
Class 1 is formed of heterodimers of alpha and B2 microglobulins what are
the three types encoded by different alpha genes?
✓ ~~> HLA-A
HLA-B
HLA-C
Alpha 1 and 2 form beta sheet and the peptide binding cleft
Alpha 3 and beta 2 form ig like domains
CDc8 - stabilisation.
Class 2 is formed if heterodimers of alpha and beta chains with two
transmembrane peptides what are the three tyoes?
✓ ~~> HLA-DP
HLA-DQ
HLA-DR
Master01 | September, 2024/2025 | Latest update
CMB2004 Questions and Answer |
Latest Update 2024/2025
Are B and T lymphocytes part of the adaptive or innate immune response?
✓ ~~> Adaptive it is the immune memory evolved over time
What is the clonal selection theory?
✓ ~~> Immature lymphocytes that could self find are destroyed
Mature naive lymphocytes are mature until they are exposed to antigens
What are the two types of B receptor?
✓ ~~> Membrane bound
And released from membrane they are known as antibodies
T cell receptors are only membrane bound and are formed of what
heterodimer?
✓ ~~> Alpha and beta chains
Antibodies are formed if a light and heavy chain, what interactions are there
between the two?
Master01 | September, 2024/2025 | Latest update
, 2 | P a g e | © copyright 2024/2025 | Grade A+
✓ ~~> Disulphide bridge (Hinge region)
And non covalent interactions
What forms the N terminal region of an antibody?
✓ ~~> The antigen binding site of the light and heavy chain known as
the variable region
The C terminal constant region is also known as what?
✓ ~~> The FC region (fragment crystallisable)
The region containing the variable region is called FAB (fragment antigen
binding)
Glycosylation of C2 modulates binding of heavy chain
The light chains are either lambda or kappa, what chromosome encodes
each?
✓ ~~> Lambda = chromosome 22 - 30 V genes and 7J
Kappa = chromosome 2 - 52 V genes and 5J
There are 5 isotopes of antibody, what are they?
Master01 | September, 2024/2025 | Latest update
, 3 | P a g e | © copyright 2024/2025 | Grade A+
✓ ~~> IgM, IgD, IgG, IgE, IgA
How many hyper variable loops are there in total?
✓ ~~> 6
3 in Vh and Vl
What are complimentary determing regions?
✓ ~~> Sections of the variable region which bind the antigen
What is an epitope?
✓ ~~> the part of an antigen molecule to which an antibody attaches
itself
Can be linear = continuous
Conformational = discontinuous
Multitalented antigen - antigen with more than one epitope
What is MHC called in humans?
✓ ~~> Human Leukocyte Antigen (HLA)
Master01 | September, 2024/2025 | Latest update
, 4 | P a g e | © copyright 2024/2025 | Grade A+
Which cells present MHCI?
And MHCII?
✓ ~~> I = on all nucleated cells
II = specialised immune cells
Class 1 is formed of heterodimers of alpha and B2 microglobulins what are
the three types encoded by different alpha genes?
✓ ~~> HLA-A
HLA-B
HLA-C
Alpha 1 and 2 form beta sheet and the peptide binding cleft
Alpha 3 and beta 2 form ig like domains
CDc8 - stabilisation.
Class 2 is formed if heterodimers of alpha and beta chains with two
transmembrane peptides what are the three tyoes?
✓ ~~> HLA-DP
HLA-DQ
HLA-DR
Master01 | September, 2024/2025 | Latest update
