1 | P a g e | © copyright 2024/2025 | Grade A+
CMB2004 Lecture 4 Questions and
Answer | Latest Update 2024/2025
Origin of haematopoietic stem cells?
~~> Bone marrow
Site of B cell development to the stage of immature B cell?
~~> Bone Marrow
what light chain is expressed first?
~~> kappa
If BCR expressed by immature B cell binds to self cell surface antigen, the B
cell is removed via?
~~> negative selection
TF that haematopoeitic cells express leading to B cell development
~~> PAX5
Activated B cells in the periphery can develop into?
Master01 | September, 2024/2025 | Latest update
, 2 | P a g e | © copyright 2024/2025 | Grade A+
~~> plasma/memory cells
Which Ig chain is re-arranged first
~~> Heavy chain
What is the surrogate light chain
~~> produced by vpreB and gamma 5 to bind to H chain and make sure it
works
Which gene segments get re-arranged in the heavy/light chains?
~~> heavy= V/D/J, Light = V/J = Kappa/Lambda
Which stage of B cell development sees the most cell division
~~> Activation of B cells to produce plasma cells
what do the RAG 1 and 2 genes do and when
~~> Gene recombination, for Heavy/light chain rearrangement
what is the fate of a pre-B cell with non-productive rearrangements of the
light chain genes
Master01 | September, 2024/2025 | Latest update
CMB2004 Lecture 4 Questions and
Answer | Latest Update 2024/2025
Origin of haematopoietic stem cells?
~~> Bone marrow
Site of B cell development to the stage of immature B cell?
~~> Bone Marrow
what light chain is expressed first?
~~> kappa
If BCR expressed by immature B cell binds to self cell surface antigen, the B
cell is removed via?
~~> negative selection
TF that haematopoeitic cells express leading to B cell development
~~> PAX5
Activated B cells in the periphery can develop into?
Master01 | September, 2024/2025 | Latest update
, 2 | P a g e | © copyright 2024/2025 | Grade A+
~~> plasma/memory cells
Which Ig chain is re-arranged first
~~> Heavy chain
What is the surrogate light chain
~~> produced by vpreB and gamma 5 to bind to H chain and make sure it
works
Which gene segments get re-arranged in the heavy/light chains?
~~> heavy= V/D/J, Light = V/J = Kappa/Lambda
Which stage of B cell development sees the most cell division
~~> Activation of B cells to produce plasma cells
what do the RAG 1 and 2 genes do and when
~~> Gene recombination, for Heavy/light chain rearrangement
what is the fate of a pre-B cell with non-productive rearrangements of the
light chain genes
Master01 | September, 2024/2025 | Latest update
