Immunology Rotation PASSED Exam
Questions and CORRECT Answers
From the following, identify a specific component of the adaptive immune system that is
formed in response to antigenic stimulation:
A. Lysozyme
B. Complement
C. Commensal organisms
D. Immunoglobulin - CORRECT ANSWER- ✔✔Immunoglobulin
Which two organs are considered the primary lymphoid organs in which immunocompetent
cells originate and mature?
A. Thyroid and Peyer's patches
B. Thymus and bone marrow
C. Spleen and mucosal-associated lymphoid tissue (MALT)
D. Lymph nodes and thoracic duct - CORRECT ANSWER- ✔✔Thymus and bone marrow
What type of B cells are formed after antigen stimulation?
A. Plasma cells and memory B cells
B. Mature B cells
C. Antigen-dependent B cells
D. Receptor-activated B cells - CORRECT ANSWER- ✔✔Plasma cells and memory B cells
T cells travel from the bone marrow to the thymus for maturation. What is the correct order
of the maturation sequence for T cells in the thymus?
A. Bone marrow to the cortex; after thymic education, released back to peripheral circulation
B. Maturation and selection occur in the cortex; migration to the medulla; release of mature T
cells to secondary lymphoid organs
C. Storage in either the cortex or medulla; release of T cells into the peripheral circulation
D. Activation and selection occur in the medulla; mature T cells are stored in the cortex until
activated by antigen - CORRECT ANSWER- ✔✔Maturation and selection occur in the
cortex; migration to the medulla; release of mature T cells to secondary lymphoid organs
,Which cluster of differentiation (CD) marker appears during the first stage of T-cell
development and remains present as an identifying marker for T cells?
A. CD1
B. CD2
C. CD3
D. CD4 or CD8 - CORRECT ANSWER- ✔✔CD2
Which markers are found on mature, peripheral helper T cells?
A. CD1, CD2, CD4
B. CD2, CD3, CD8
C. CD1, CD3, CD4
D. CD2, CD3, CD4 - CORRECT ANSWER- ✔✔CD2, CD3, CD4
Which T cell expresses the CD8 marker and acts specifically to kill tumors or virally infected
cells?
A. Helper T
B. T suppressor
C. T cytotoxic
D. T inducer/suppressor - CORRECT ANSWER- ✔✔T cytotoxic
How are cytotoxic T cells (TC cells) and natural killer (NK) cells similar?
A. Require antibody to be present
B. Effective against virally infected cells
C. Recognize antigen in association with HLA class II markers
D. Do not bind to infected cells - CORRECT ANSWER- ✔✔Effective against virally
infected cells
What is the name of the process by which phagocytic cells are attracted to a substance such
as a bacterial peptide?
A. Diapedesis
,B. Degranulation
C. Chemotaxis
D. Phagotaxis - CORRECT ANSWER- ✔✔Chemotaxis
All of the following are immunologic functions of complement except:
A. Induction of an antiviral state
B. Opsonization
C. Chemotaxis
D. Anaphylatoxin formation - CORRECT ANSWER- ✔✔Induction of an antiviral state
Which complement component is found in both the classic and alternative pathways?
A. C1
B. C4
C. Factor D
D. C3 - CORRECT ANSWER- ✔✔C3
Which immunoglobulin(s) help(s) initiate the classic complement pathway?
A. IgA and IgD
B. IgM only
C. IgG and IgM
D. IgG only - CORRECT ANSWER- ✔✔IgG and IgM
How is complement activity destroyed in vitro?
A. Heating serum at 56°C for 30 min
B. Keeping serum at room temperature of 22°C for 1 hour
C. Heating serum at 37°C for 45 min
D. Freezing serum at 0°C for 24 hours - CORRECT ANSWER- ✔✔Heating serum at 56°C
for 30 min
What is the purpose of C3a, C4a, and C5a, the split products of the complement cascade?
, A. To bind with specific membrane receptors of lymphocytes and cause release of cytotoxic
substances
B. To cause increased vascular permeability, contraction of smooth muscle, and release of
histamine from basophils
C. To bind with membrane receptors of macrophages to facilitate phagocytosis and the
removal of debris and foreign substances
D. To regulate and degrade membrane cofactor protein after activation by C3 convertase -
CORRECT ANSWER- ✔✔To cause increased vascular permeability, contraction of smooth
muscle, and release of histamine from basophils
Which region of the immunoglobulin molecule can bind antigen?
A. Fab
B. Fc
C. CL
D. CH - CORRECT ANSWER- ✔✔Fab
Which region determines whether an immunoglobulin molecule can fix complement?
A. VH
B. CH
C. VL
D. CL - CORRECT ANSWER- ✔✔CH
Which immunoglobulin class(es) has (have) a J chain?
A. IgM
B. IgE and IgD
C. IgM and sIgA
D. IgG3 and IgA - CORRECT ANSWER- ✔✔IgM and sIgA
Which immunoglobulin appears first in the primary immune response?
A. IgG
B. IgM
C. IgA
Questions and CORRECT Answers
From the following, identify a specific component of the adaptive immune system that is
formed in response to antigenic stimulation:
A. Lysozyme
B. Complement
C. Commensal organisms
D. Immunoglobulin - CORRECT ANSWER- ✔✔Immunoglobulin
Which two organs are considered the primary lymphoid organs in which immunocompetent
cells originate and mature?
A. Thyroid and Peyer's patches
B. Thymus and bone marrow
C. Spleen and mucosal-associated lymphoid tissue (MALT)
D. Lymph nodes and thoracic duct - CORRECT ANSWER- ✔✔Thymus and bone marrow
What type of B cells are formed after antigen stimulation?
A. Plasma cells and memory B cells
B. Mature B cells
C. Antigen-dependent B cells
D. Receptor-activated B cells - CORRECT ANSWER- ✔✔Plasma cells and memory B cells
T cells travel from the bone marrow to the thymus for maturation. What is the correct order
of the maturation sequence for T cells in the thymus?
A. Bone marrow to the cortex; after thymic education, released back to peripheral circulation
B. Maturation and selection occur in the cortex; migration to the medulla; release of mature T
cells to secondary lymphoid organs
C. Storage in either the cortex or medulla; release of T cells into the peripheral circulation
D. Activation and selection occur in the medulla; mature T cells are stored in the cortex until
activated by antigen - CORRECT ANSWER- ✔✔Maturation and selection occur in the
cortex; migration to the medulla; release of mature T cells to secondary lymphoid organs
,Which cluster of differentiation (CD) marker appears during the first stage of T-cell
development and remains present as an identifying marker for T cells?
A. CD1
B. CD2
C. CD3
D. CD4 or CD8 - CORRECT ANSWER- ✔✔CD2
Which markers are found on mature, peripheral helper T cells?
A. CD1, CD2, CD4
B. CD2, CD3, CD8
C. CD1, CD3, CD4
D. CD2, CD3, CD4 - CORRECT ANSWER- ✔✔CD2, CD3, CD4
Which T cell expresses the CD8 marker and acts specifically to kill tumors or virally infected
cells?
A. Helper T
B. T suppressor
C. T cytotoxic
D. T inducer/suppressor - CORRECT ANSWER- ✔✔T cytotoxic
How are cytotoxic T cells (TC cells) and natural killer (NK) cells similar?
A. Require antibody to be present
B. Effective against virally infected cells
C. Recognize antigen in association with HLA class II markers
D. Do not bind to infected cells - CORRECT ANSWER- ✔✔Effective against virally
infected cells
What is the name of the process by which phagocytic cells are attracted to a substance such
as a bacterial peptide?
A. Diapedesis
,B. Degranulation
C. Chemotaxis
D. Phagotaxis - CORRECT ANSWER- ✔✔Chemotaxis
All of the following are immunologic functions of complement except:
A. Induction of an antiviral state
B. Opsonization
C. Chemotaxis
D. Anaphylatoxin formation - CORRECT ANSWER- ✔✔Induction of an antiviral state
Which complement component is found in both the classic and alternative pathways?
A. C1
B. C4
C. Factor D
D. C3 - CORRECT ANSWER- ✔✔C3
Which immunoglobulin(s) help(s) initiate the classic complement pathway?
A. IgA and IgD
B. IgM only
C. IgG and IgM
D. IgG only - CORRECT ANSWER- ✔✔IgG and IgM
How is complement activity destroyed in vitro?
A. Heating serum at 56°C for 30 min
B. Keeping serum at room temperature of 22°C for 1 hour
C. Heating serum at 37°C for 45 min
D. Freezing serum at 0°C for 24 hours - CORRECT ANSWER- ✔✔Heating serum at 56°C
for 30 min
What is the purpose of C3a, C4a, and C5a, the split products of the complement cascade?
, A. To bind with specific membrane receptors of lymphocytes and cause release of cytotoxic
substances
B. To cause increased vascular permeability, contraction of smooth muscle, and release of
histamine from basophils
C. To bind with membrane receptors of macrophages to facilitate phagocytosis and the
removal of debris and foreign substances
D. To regulate and degrade membrane cofactor protein after activation by C3 convertase -
CORRECT ANSWER- ✔✔To cause increased vascular permeability, contraction of smooth
muscle, and release of histamine from basophils
Which region of the immunoglobulin molecule can bind antigen?
A. Fab
B. Fc
C. CL
D. CH - CORRECT ANSWER- ✔✔Fab
Which region determines whether an immunoglobulin molecule can fix complement?
A. VH
B. CH
C. VL
D. CL - CORRECT ANSWER- ✔✔CH
Which immunoglobulin class(es) has (have) a J chain?
A. IgM
B. IgE and IgD
C. IgM and sIgA
D. IgG3 and IgA - CORRECT ANSWER- ✔✔IgM and sIgA
Which immunoglobulin appears first in the primary immune response?
A. IgG
B. IgM
C. IgA
