PHCY 402 Exam 3 Questions And
Correct Answers
typical gentamicin regimen - Answer -1 mg/kg over 30 min
-q8 hours
aminoglycoside should be used in caution with patient with ___ - Answer neuromuscular
disorders (ex: myasthenia gravis)
typical gentamicin peak and trough - Answer peak: 4-10
trough: 1-2
if ran too quickly, ahminoglycosides are associated with - Answer -high-frequency
sound loss
-nephrotoxicity
half-life formula - Answer 0.693/k
tobramycin is dosed the same as - Answer gentamycin
_____ is the most important step in elimination via the kidney - Answer glomerular
filtration
how to determine filtration rate - Answer monitor a known amount of a substance that
only undergoes glomular filtration and tract how long it takes to come out (via urine)
inulin - Answer exogenous
only undergoes glomular filtration
collect urine for 24 hours
example of a good eGFR - Answer 100 mL/min
a person with no kidneys would have a GFR of - Answer zero
determine GFR from urine - Answer [urine]/[serum] * (urine vol)/(time)
-divide by 60 to convert to minutes
creatineine - Answer endogenous
comes from muscle breakdown
, not made in adipose tissue
____ is the BEST estimate of GFR - Answer urine collection over 24 hours
problems with 24 hour urine collection - Answer -timing
-patient forgets to collect into jug
-cost
-takes 24 hours
factors in cockroft-gault equation - Answer SCr, age, gender, IBW
if SCr levels are less than 1, ____ - Answer round up to 1
T/F: you can use cockroft-gault equation in children - Answer false
-use schwartz equation
variables in the 2009 MDRD and CKD-EPI equation - Answer -USED: SCr, age, gender,
race
-Not used: weight, height
new CKD-EPI equation - Answer no longer factors in race
-only uses age, gender, SCr
Cystatin C - Answer -produced by all nucleated cells in the body
-minimally affected by age, gender, race, muscle mass, disease
concentration formula - Answer dose divided by volume
adults volume of distribution - Answer -4.7 liters of blood
-42 liters of water
-volume of distribution is NOT a real volume, and thus not the amount of blood or water
in a human
volume of distribution equation only works at - Answer steady state (5 half lives)
average half-life of gentamicin - Answer 2-3 hours
Vd formula from population averages - Answer 0.24 (weight)
process for creating regimens - Answer 1) estimate Kel and Vd
2) determine dosing interval (tau)
3) determine dose
Correct Answers
typical gentamicin regimen - Answer -1 mg/kg over 30 min
-q8 hours
aminoglycoside should be used in caution with patient with ___ - Answer neuromuscular
disorders (ex: myasthenia gravis)
typical gentamicin peak and trough - Answer peak: 4-10
trough: 1-2
if ran too quickly, ahminoglycosides are associated with - Answer -high-frequency
sound loss
-nephrotoxicity
half-life formula - Answer 0.693/k
tobramycin is dosed the same as - Answer gentamycin
_____ is the most important step in elimination via the kidney - Answer glomerular
filtration
how to determine filtration rate - Answer monitor a known amount of a substance that
only undergoes glomular filtration and tract how long it takes to come out (via urine)
inulin - Answer exogenous
only undergoes glomular filtration
collect urine for 24 hours
example of a good eGFR - Answer 100 mL/min
a person with no kidneys would have a GFR of - Answer zero
determine GFR from urine - Answer [urine]/[serum] * (urine vol)/(time)
-divide by 60 to convert to minutes
creatineine - Answer endogenous
comes from muscle breakdown
, not made in adipose tissue
____ is the BEST estimate of GFR - Answer urine collection over 24 hours
problems with 24 hour urine collection - Answer -timing
-patient forgets to collect into jug
-cost
-takes 24 hours
factors in cockroft-gault equation - Answer SCr, age, gender, IBW
if SCr levels are less than 1, ____ - Answer round up to 1
T/F: you can use cockroft-gault equation in children - Answer false
-use schwartz equation
variables in the 2009 MDRD and CKD-EPI equation - Answer -USED: SCr, age, gender,
race
-Not used: weight, height
new CKD-EPI equation - Answer no longer factors in race
-only uses age, gender, SCr
Cystatin C - Answer -produced by all nucleated cells in the body
-minimally affected by age, gender, race, muscle mass, disease
concentration formula - Answer dose divided by volume
adults volume of distribution - Answer -4.7 liters of blood
-42 liters of water
-volume of distribution is NOT a real volume, and thus not the amount of blood or water
in a human
volume of distribution equation only works at - Answer steady state (5 half lives)
average half-life of gentamicin - Answer 2-3 hours
Vd formula from population averages - Answer 0.24 (weight)
process for creating regimens - Answer 1) estimate Kel and Vd
2) determine dosing interval (tau)
3) determine dose
