PHCY 402 - Vancomycin Study
Set Exam
polar; large - Answer vancomycin is too ___ to penetrate the outer membrane and too
___ to pass through porin channels
vancomycin (vancocin, vancoled) - Answer DOC for MRSA
PMC (c. diff super infection) - Answer vancomycin is only used orally to treat ____
true - Answer T/F: you must monitor serum levels of vancomycin to ensure efficacy and
reduce toxicity
polymerization (of the amino sugars) - Answer Beta-lactams inhibit cross-linking;
glycopeptides inhibit ____
Lipid II - Answer ____ shuttles NAG-NAM precursors to the GT enzymes that form the
growing polymer
5 (very high affinity) - Answer Vancomycin binds to Lipid II with __ hydrogen bonds
H-bond donor - Answer Vancomycin resistant mutation removes a critical ____, which
decreases binding affinity by 1000 fold
red man syndrome - Answer common side effect to vancomycin; red back/neck/face
caused by rapid histamine release into bloodstream if injected too fast
slow; antihistamines - Answer vancomycin should be given in a (slow/fast) infusion,
along with ____ every 1-2 hours
Nephrotoxicity/ototoxicity - Answer What rare side effects of vancomycin have an
increased chance when administered along with aminoglycosides?
myocardial infarction - Answer in red man syndrome, histamine --> seizures --> _________
lipid appendage - Answer lipoglycopeptides are just glycopeptides with the addition of a
_____
true - Answer T/F: the lipid appendage addition in lipoglycopeptides counters some loss
of affinity in Vancomycin-
resistant mutants with decreased H-bonding
telavancin (vibativ) - Answer lipoglycopeptide with long half life; produces detergent like
effects against cell membrane; Tx - MRSA complicated skin infections
Set Exam
polar; large - Answer vancomycin is too ___ to penetrate the outer membrane and too
___ to pass through porin channels
vancomycin (vancocin, vancoled) - Answer DOC for MRSA
PMC (c. diff super infection) - Answer vancomycin is only used orally to treat ____
true - Answer T/F: you must monitor serum levels of vancomycin to ensure efficacy and
reduce toxicity
polymerization (of the amino sugars) - Answer Beta-lactams inhibit cross-linking;
glycopeptides inhibit ____
Lipid II - Answer ____ shuttles NAG-NAM precursors to the GT enzymes that form the
growing polymer
5 (very high affinity) - Answer Vancomycin binds to Lipid II with __ hydrogen bonds
H-bond donor - Answer Vancomycin resistant mutation removes a critical ____, which
decreases binding affinity by 1000 fold
red man syndrome - Answer common side effect to vancomycin; red back/neck/face
caused by rapid histamine release into bloodstream if injected too fast
slow; antihistamines - Answer vancomycin should be given in a (slow/fast) infusion,
along with ____ every 1-2 hours
Nephrotoxicity/ototoxicity - Answer What rare side effects of vancomycin have an
increased chance when administered along with aminoglycosides?
myocardial infarction - Answer in red man syndrome, histamine --> seizures --> _________
lipid appendage - Answer lipoglycopeptides are just glycopeptides with the addition of a
_____
true - Answer T/F: the lipid appendage addition in lipoglycopeptides counters some loss
of affinity in Vancomycin-
resistant mutants with decreased H-bonding
telavancin (vibativ) - Answer lipoglycopeptide with long half life; produces detergent like
effects against cell membrane; Tx - MRSA complicated skin infections
